Lung function in preschool children with a history of wheezing measured by forced oscillation and plethysmographic specific airway resistance

2010 ◽  
Vol 45 (11) ◽  
pp. 1049-1056 ◽  
Author(s):  
Jo Harrison ◽  
Anne-Marie Gibson ◽  
Khrista Johnson ◽  
Gauharjit Singh ◽  
Billy Skoric ◽  
...  
Keyword(s):  
Preschool Children ◽  
Lung Function ◽  
Airway Resistance ◽  
Forced Oscillation ◽  
Specific Airway Resistance ◽  
History Of

scholarly journals Specific airway resistance in preschool children: why not panting after all?

2016 ◽  
Vol 48 (6) ◽  
pp. 1804-1807 ◽  
Author(s):  
Iulia Ioan ◽  
Silvia Demoulin-Alexikova ◽  
Laurianne Coutier ◽  
Claude Bonabel ◽  
Jane Kirkby ◽  
...  
Keyword(s):  
Preschool Children ◽  
Airway Resistance ◽  
Specific Airway Resistance

Relationship between baseline and post-bronchodilator interrupter resistance and specific airway resistance in preschool children

2020 ◽  
Vol 124 (4) ◽  
pp. 366-372
Author(s):  
Pauline Mauger-Hamel ◽  
Cécile Du Boisbaudry ◽  
Karelle Léon ◽  
Zarrin Alavi ◽  
Marie-Agnès Giroux-Metges
Keyword(s):  
Preschool Children ◽  
Airway Resistance ◽  
Specific Airway Resistance

scholarly journals Lung function assessment using the interrupter technique in infants and preschool children

2009 ◽  
pp. 55-58
Author(s):  
E. G. Furman ◽  
M. S. Ponomareva ◽  
A. M. Yarulina ◽  
I. P. Koryukina ◽  
A. R. Abdullaev
Keyword(s):  
Atopic Dermatitis ◽  
Preschool Children ◽  
Lung Function ◽  
Airway Resistance ◽  
Acute Bronchitis ◽  
Healthy Children ◽  
Mathematic Modeling ◽  
Children With Asthma ◽  
Function Assessment

There are numerous problems regarding lung function assessment in infants and preschool children despite the great interest to this field worldwide. Therefore, investigations of the interrupter technique in infants and preschool children are of great importance. This article contains results of measurement of airway resistance in children with asthma, atopic dermatitis, acute bronchitis and croup and in healthy children using the interrupter technique. Results of mathematic modeling have also been discussed in the article.

scholarly journals Reference values of interrupter respiratory resistance in healthy preschool white children

Thorax ◽  
2001 ◽  
Vol 56 (9) ◽  
pp. 691-695
Author(s):  
E Lombardi ◽  
P D Sly ◽  
G Concutelli ◽  
E Novembre ◽  
G Veneruso ◽  
...  
Keyword(s):  
Preschool Children ◽  
Lung Function ◽  
Reference Values ◽  
Univariate Analysis ◽  
Healthy Children ◽  
Respiratory Resistance ◽  
Short Term ◽  
White Children ◽  
History Of

BACKGROUNDInterrupter respiratory resistance (Rint) is reported to be useful in evaluating lung function in poorly collaborating patients. However, no reference values are available from large samples of preschool children using the standard interrupter method. The aim of this study was to define reference Rint values in a population of healthy preschool children.METHODSRint was assessed without supporting the cheeks in children with no history of wheeze from six kindergartens. To evaluate the effects of upper airway compliance on Rint in healthy children, an additional group of preschool children with either no history of wheeze or no respiratory symptoms at the time of testing underwent Rint measurements in our lung function laboratory with and without supporting the cheeks. Short term (about 1 minute apart) and long term (mean 2.5 months apart) repeatability of Rint measurements (2 SDs of the mean paired difference between measurements) was also assessed in children referred for cough or wheeze.RESULTSA total of 284 healthy white children (age range 3.0–6.4 years) were evaluated. Mean inspiratory and expiratory Rint (Rinti and Rinte) did not differ significantly in boys and girls. Age, height, and weight showed a significant inverse correlation with both Rinti and Rinte in the univariate analysis with linear regression. Multiple regression with age, height, and weight as the independent variables showed that all three variables were significantly and independently correlated with Rinti, whereas only height was significantly and independently correlated with Rinte. Supporting the cheeks had no significant effect on Rinti (n=29, median 0.673 v0.660 kPa/l.s, p=0.098) or Rinte (n=39, median 0.702v 0.713 kPa/l.s, p=0.126). Short term repeatability was 0.202 kPa/l.s for Rinti (n=50) and 0.242 kPa/l.s for Rinte (n=69). Long term repeatability was 0.208 kPa/l.s for Rinte (n=26).CONCLUSIONSWe have reported reference Rint values in preschool white children and have demonstrated the usefulness of this technique in assessing lung function in this age group.

scholarly journals Comparison of unrestrained plethysmography and forced oscillation for identifying genetic variability of airway responsiveness in inbred mice

2011 ◽  
Vol 43 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Annerose Berndt ◽  
Adriana S. Leme ◽  
Laura K. Williams ◽  
Randy Von Smith ◽  
Holly S. Savage ◽  
...  
Keyword(s):  
Lung Function ◽  
Airway Resistance ◽  
Forced Oscillation ◽  
Association Studies ◽  
Genome Wide Association ◽  
Mouse Strains ◽  
Forced Oscillation Technique ◽  
Genome Wide Association Studies ◽  
Lung Elastance ◽  
Genome Wide

Lung function detection in mice is currently most accurately measured by invasive techniques, which are costly, labor intensive, and terminal. This limits their use for large-scale or longitudinal studies. Noninvasive assays are often used instead, but their accuracy for measuring lung function parameters such as resistance and elastance has been questioned in studies involving small numbers of mouse strains. Here we compared parameters detected by two different methods using 29 inbred mouse strains: enhanced pause (Penh), detected by unrestrained plethysmography, and central airway resistance and lung elastance, detected by a forced oscillation technique. We further tested whether the phenotypic variations were determined by the same genomic location in genome-wide association studies using a linear mixed model algorithm. Penh, resistance, and elastance were measured in nonexposed mice or mice exposed to saline and increasing doses of aerosolized methacholine. Because Penh differed from airway resistance in several strains and because the peak genetic associations found for Penh, resistance, or elastance were located at different genomic regions, we conclude that using Penh as an indicator for lung function changes in high-throughput genetic studies (i.e., genome-wide association studies or quantitative trait locus studies) measures something fundamentally different than airway resistance and lung elastance.

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