scholarly journals Environmental exposures, nitric oxide synthase genes, and exhaled nitric oxide in asthmatic children

2009 ◽  
Vol 44 (8) ◽  
pp. 812-819 ◽  
Author(s):  
Adam J. Spanier ◽  
Robert S. Kahn ◽  
Richard W. Hornung ◽  
Ning Wang ◽  
Guangyun Sun ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Environmental Exposures ◽  
Exhaled Nitric Oxide ◽  
Asthmatic Children ◽  
Oxide Synthase

Inhibitors of nitric oxide synthase can reduce extracellular traps from neutrophils in asthmatic children in vitro

2019 ◽  
Vol 55 (1) ◽  
pp. 68-75
Author(s):  
Wen‐Xuan Li ◽  
Fei Wang ◽  
Yun‐Qian Zhu ◽  
Li‐Mei Zhang ◽  
Zhen‐Hua Zhang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Asthmatic Children ◽  
Extracellular Traps ◽  
Oxide Synthase

Exhaled Nitric Oxide Production by Nitric Oxide Synthase–deficient Mice

2000 ◽  
Vol 162 (4) ◽  
pp. 1262-1267 ◽  
Author(s):  
WOLFGANG STEUDEL ◽  
MAX KIRMSE ◽  
JÖRG WEIMANN ◽  
ROMAN ULLRICH ◽  
JONATHAN HROMI ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Exhaled Nitric Oxide ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Oxide Synthase ◽  
Deficient Mice

scholarly journals Genetic variations in nitric oxide synthase and arginase influence exhaled nitric oxide levels in children

Allergy ◽  
2010 ◽  
Vol 66 (3) ◽  
pp. 412-419 ◽  
Author(s):  
M. T. Salam ◽  
T. M. Bastain ◽  
E. B. Rappaport ◽  
T. Islam ◽  
K. Berhane ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Genetic Variations ◽  
Exhaled Nitric Oxide ◽  
Oxide Synthase

Fine Particulate Matter Constituents, Nitric Oxide Synthase DNA Methylation and Exhaled Nitric Oxide

2015 ◽  
Vol 49 (19) ◽  
pp. 11859-11865 ◽  
Author(s):  
Renjie Chen ◽  
Liping Qiao ◽  
Huichu Li ◽  
Yan Zhao ◽  
Yunhui Zhang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Dna Methylation ◽  
Particulate Matter ◽  
Nitric Oxide Synthase ◽  
Fine Particulate Matter ◽  
Exhaled Nitric Oxide ◽  
Fine Particulate ◽  
Oxide Synthase

Contributions of nitric oxide synthase isozymes to exhaled nitric oxide and hypoxic pulmonary vasoconstriction in rabbit lungs

2003 ◽  
Vol 284 (5) ◽  
pp. L834-L843 ◽  
Author(s):  
David J. Vaughan ◽  
Thomas V. Brogan ◽  
Mark E. Kerr ◽  
Steven Deem ◽  
Daniel L. Luchtel ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Hypoxic Pulmonary Vasoconstriction ◽  
Exhaled Nitric Oxide ◽  
No Production ◽  
Rabbit Lung ◽  
Pulmonary Vasoconstriction ◽  
Exhaled No ◽  
Nos Inhibitors ◽  
Oxide Synthase

We investigated the source(s) for exhaled nitric oxide (NO) in isolated, perfused rabbits lungs by using isozyme-specific nitric oxide synthase (NOS) inhibitors and antibodies. Each inhibitor was studied under normoxia and hypoxia. Only nitro-l-arginine methyl ester (l-NAME, a nonselective NOS inhibitor) reduced exhaled NO and increased hypoxic pulmonary vasoconstriction (HPV), in contrast to 1400W, an inhibitor of inducible NOS (iNOS), and 7-nitroindazole, an inhibitor of neuronal NOS (nNOS). Acetylcholine-mediated stimulation of vascular endothelial NOS (eNOS) increased exhaled NO and could only be inhibited by l-NAME. Selective inhibition of airway and alveolar epithelial NO production by nebulized l-NAME decreased exhaled NO and increased hypoxic pulmonary artery pressure. Immunohistochemistry demonstrated extensive staining for eNOS in the epithelia, vasculature, and lymphatic tissue. There was no staining for iNOS but moderate staining for nNOS in the ciliated cells of the epithelia, lymphoid tissue, and cartilage cells. Our findings show virtually all exhaled NO in the rabbit lung is produced by eNOS, which is present throughout the airways, alveoli, and vessels. Both vascular and epithelial-derived NO modulate HPV.

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