scholarly journals Developmental differences in the contractile response of isolated ovine tracheal smooth muscle cells

2009 ◽  
Vol 44 (6) ◽  
pp. 602-612 ◽  
Author(s):  
Rachel E. Laudadio ◽  
Marla R. Wolfson ◽  
Thomas H. Shaffer ◽  
Steven P. Driska
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Contractile Response ◽  
Muscle Cells ◽  
Developmental Differences ◽  
Tracheal Smooth Muscle

Effects of Histamine and Endothelin-1 on Membrane Potentials and Ion Currents in Bovine Tracheal Smooth-Muscle Cells

1998 ◽  
Vol 19 (5) ◽  
pp. 805-811 ◽  
Author(s):  
Masayuki Nara ◽  
Tsukasa Sasaki ◽  
Sanae Shimura ◽  
Takako Oshiro ◽  
Toshiya Irokawa ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Membrane Potentials ◽  
Tracheal Smooth Muscle ◽  
Ion Currents ◽  
Endothelin 1

Muscarinic stimulation of tracheal smooth muscle cells activates large-conductance Ca2+-dependent K+ channel

1997 ◽  
Vol 272 (3) ◽  
pp. 1-1 ◽  
Author(s):  
G. R. Wade ◽  
S. M. Sims
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Tracheal Smooth Muscle ◽  
K Channel ◽  
Muscarinic Stimulation ◽  
Cholinergic Response ◽  
Stimulation Of

Pages C658-C665: G. R. Wade and S. M. Sims. “Muscarinic stimulation of tracheal smooth muscle cells activates large-conductance Ca2+-dependent K+ channel.” Page C662, Fig. 6: the second half of the trace in A was inadvertently duplicated from B. The revised Fig. 6 below shows the correct channel traces. We wish to emphasize that the scientific point of the figure, the reversible antagonism of the cholinergic response by atropine, as well as the quantification in D, remains sound. The data were filtered at 400 Hz and sampled off-line from digital videotape at 2 kHz. (See PDF)

p21-activated kinase 1 participates in tracheal smooth muscle cell migration by signaling to p38 MAPK

2001 ◽  
Vol 281 (1) ◽  
pp. C123-C132 ◽  
Author(s):  
Melissa A. Dechert ◽  
Jennifer M. Holder ◽  
William T. Gerthoffer
Keyword(s):  
Smooth Muscle ◽  
Cell Migration ◽  
Smooth Muscle Cells ◽  
P38 Mapk ◽  
Mammalian Cells ◽  
Muscle Cells ◽  
Mitogen Activated Protein Kinase ◽  
Tracheal Smooth Muscle ◽  
Wild Type ◽  
P21 Activated Kinase

Cell migration contributes to many physiological processes and requires dynamic changes in the cytoskeleton. These migration-dependent cytoskeletal changes are partly mediated by p21-activated protein kinases (PAKs). At least four closely related isoforms, PAK1, PAK2, PAK3, and PAK4, exist in mammalian cells. In smooth muscle cells, little is known about the expression, activation, or ability of PAKs to regulate migration. Our study revealed the existence of three PAK isoforms in cultured tracheal smooth muscle cells (TSMCs). Additionally, we constructed adenoviral vectors encoding wild type and a catalytically inactive PAK1 mutant to investigate PAK activation and its role in TSMC migration. Stimulation of TSMCs with platelet-derived growth factor (PDGF) increased the activity of PAK1 over time. Overexpression of mutant PAK1 blocked PDGF-induced chemotactic cell migration. Phosphorylation of p38 mitogen-activated protein kinase (MAPK) in cells overexpressing wild-type PAK1 was similar to vector controls; however, p38 MAPK phosphorylation was severely reduced by overexpression of the PAK1 mutant. Collectively, these results suggest a role for PAK1 in chemotactic TSMC migration that involves catalytic activity and may require signaling to p38 MAPK among other pathways.

Sarafotoxin-Induced Calcium Mobilization in Cultured Dog Tracheal Smooth Muscle Cells

1994 ◽  
Vol 14 (6-8) ◽  
pp. 423-445 ◽  
Author(s):  
Chuenchuen Mao Yang ◽  
Richard Ong ◽  
Jen-Tsung Hsieh ◽  
Ying-Ling Yo
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Calcium Mobilization ◽  
Tracheal Smooth Muscle
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