The potential use of spirometry during methacholine challenge test in young children with respiratory symptoms

2009 ◽  
Vol 44 (7) ◽  
pp. 720-727 ◽  
Author(s):  
Daphna Vilozni ◽  
Galit Livnat ◽  
Husein Dabbah ◽  
Nael Elias ◽  
Fahed Hakim ◽  
...  
Keyword(s):  
Young Children ◽  
Respiratory Symptoms ◽  
Challenge Test ◽  
Methacholine Challenge ◽  
Methacholine Challenge Test ◽  
Potential Use

Association of methacholine challenge test with diagnosis of chronic lung allograft dysfunction in lung transplant patients

2018 ◽  
Vol 32 (10) ◽  
pp. e13397 ◽  
Author(s):  
Atif S. Siddiqui ◽  
Gagan Kumar ◽  
Tilottama Majumdar ◽  
Edward A. Graviss ◽  
Duc T. Nguyen ◽  
...  
Keyword(s):  
Lung Transplant ◽  
Challenge Test ◽  
Methacholine Challenge ◽  
Chronic Lung Allograft Dysfunction ◽  
Methacholine Challenge Test ◽  
Allograft Dysfunction ◽  
Transplant Patients

Methacholine challenge test by wheezing and oxygen saturation in preschool children with asthma

2015 ◽  
Vol 43 (2) ◽  
pp. 174-179 ◽  
Author(s):  
S. Caussade ◽  
J.A. Castro-Rodriguez ◽  
S. Contreras ◽  
R. Bugueño ◽  
R. Ramirez ◽  
...  
Keyword(s):  
Preschool Children ◽  
Oxygen Saturation ◽  
Challenge Test ◽  
Methacholine Challenge ◽  
Methacholine Challenge Test ◽  
Children With Asthma

scholarly journals Correlation between Reduced FEF25-75% and a Positive Methacholine Challenge Test in Adults with Nonobstructive Baseline Spirometry

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Irfan Shafiq ◽  
Mateen Haider Uzbeck ◽  
Zaid Zoumot ◽  
Mohamed Abuzakouk ◽  
Niyas Parappurath ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Challenge Test ◽  
Methacholine Challenge ◽  
Methacholine Challenge Test ◽  
Children With Asthma ◽  
Methacholine Test ◽  
Log Odds ◽  
Baseline Characteristics ◽  
And Gender ◽  
Small Airway Obstruction

Rationale. FEF25-75% is routinely reported on spirometry and is thought to be a marker of small airway obstruction. It is reduced in children with asthma, but its significance in adults and especially those without asthma diagnosis remains unclear. Objective. To clarify whether in adults with a nonobstructive spirometry a reduced FEF25-75% is associated with a positive methacholine challenge test (MCT). Methods. Data was collected for all the patients who had a MCT done between April 2014 and January 2020 but had nonobstructive baseline spirometry. Logistic regression was utilized to estimate the log odds of a positive methacholine test as a function of FEF25-75% and also for age, gender, BMI, FEV1, and FEV1/FVC. Results. Out of 496 patients, 187 (38%) had a positive MCT. Baseline characteristics in two groups were similar except that patients with positive MCT were younger ( 32 ± 11.57 vs. 38 ± 13.25 years, respectively, p < 0.001 ). Mean FEF25-75% was lower in MCT positive ( 3.12 ± 0.99  L/s) vs. MCT negative ( 3.39 ± 0.97  L/s) patients, p = 0.003 . Logistic regression results suggest that MCT outcome is inversely related to FEF25-75%, age, and gender. Specifically, as FEF25-75% percentage of predicted value increases, the log odds of a positive MCT decrease ( odds   ratio   OR = 0.90 , 95% confidence intervals   CI = 0.84 ‐ 0.96 , p = 0.002 ). Also, as age increases, the log odds of a positive MCT decrease ( OR = 0.95 , 95 % CI = 0.94 ‐ 0.97 , p < 0.001 ). Conclusions. Reduced FEF25-75% in adults with nonobstructive spirometry can predict a positive response to MCT in younger patients. However, this relationship becomes weaker with increasing age.

FENO is not a substitute for the methacholine challenge test in children

2018 ◽  
Author(s):  
Anja Keßler ◽  
Simon Paur ◽  
Äenne Glass ◽  
Dagmar-Christiane Fischer ◽  
Manfred Ballmann
Keyword(s):  
Challenge Test ◽  
Methacholine Challenge ◽  
Methacholine Challenge Test
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