Tumor‐Targeting W 18 O 49 Nanoparticles for Dual‐Modality Imaging and Guided Heat‐Shock‐Response‐Inhibited Photothermal Therapy in Gastric Cancer

2019 ◽  
Vol 36 (7) ◽  
pp. 1900124 ◽  
Author(s):  
Zhengyang Yang ◽  
Jiafeng Wang ◽  
Song Liu ◽  
Feng Sun ◽  
Ji Miao ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Heat Shock ◽  
Heat Shock Response ◽  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Dual Modality ◽  
Shock Response ◽  
Dual Modality Imaging

scholarly journals Cantharidin-Loaded Biomimetic MOF Nanoparticles Cascade To Enhance Fenton Reaction Based On Amplified Photothermal Therapy

2021 ◽  
Author(s):  
Xiao Cheng ◽  
Ye Liu ◽  
Hao Zhou ◽  
Junke Leng ◽  
Xiaofeng Dai ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Response ◽  
Photothermal Therapy ◽  
Fenton Reaction ◽  
Metal Organic Framework ◽  
Combined Treatment ◽  
Inhibitory Effect ◽  
Photothermal Effect ◽  
Iron Ions ◽  
Shock Response

Abstract The treatment efficiency of Fenton reaction is expected to be greatly restricted due to problems such as inefficient delivery of Fenton catalysis, limited H 2 O 2 concentration and uneven tumour tissue. Accurate photothermal therapy (PTT) can to some extent improve the efficiency of Fenton catalysis by raising temperature. However, the heat shock response (HSR) of tumour cells caused by PTT and Fenton reaction can attenuate the treatment effect. In this study, we developed a combined treatment platform based on the Fenton reaction mediated by iron ions consisting of a metal organic framework, i.e., PPy-CTD@MIL-100@MPCM nanoparticles (PCMM NPs), and we explored the inhibitory effect of PCMM NPs on the heat shock response (HSR). PCMM NPs can be recruited into tumour tissues through the response of biomacromolecules on the surface of macrophage cell membranes (MPCMs) to tumour cell signaling molecules, thereby increasing retention and accumulation. The photothermal effect of polypyrrole (PPy) can stimulate the HSR of tumour, and loaded HSP inhibitor-cantharidin (CTD) can inhibit this response to a large extent. In addition, the heat generated during the PTT process can accelerate the release of iron ions from the PCMM NPs and simultaneously improve the efficiency of the Fenton reaction to achieve a combined treatment of tumour PTT, Fenton therapy and chemotherapy.

scholarly journals Sulourea-coordinated Pd nanocubes for NIR-responsive photothermal/H2S therapy of cancer

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Xiaoyang Guo ◽  
Jia Liu ◽  
Lingdong Jiang ◽  
Wanjun Gong ◽  
Huixia Wu ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Response ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Synergetic Effect ◽  
Tumor Treatment ◽  
Photothermal Heating ◽  
Effective Combination ◽  
Shock Response ◽  
First Time

Abstract Background Photothermal therapy (PTT) frequently cause thermal resistance in tumor cells by inducing the heat shock response, limiting its therapeutic effect. Hydrogen sulfide (H2S) with appropriate concentration can reverse the Warburg effect in cancer cells. The combination of PTT with H2S gas therapy is expected to achieve synergistic tumor treatment. Methods Here, sulourea (Su) is developed as a thermosensitive/hydrolysable H2S donor to be loaded into Pd nanocubes through in-depth coordination for construction of the Pd-Su nanomedicine for the first time to achieve photo-controlled H2S release, realizing the effective combination of photothermal therapy and H2S gas therapy. Results The Pd-Su nanomedicine shows a high Su loading capacity (85 mg g−1), a high near-infrared (NIR) photothermal conversion efficiency (69.4%), and NIR-controlled H2S release by the photothermal-triggered hydrolysis of Su. The combination of photothermal heating and H2S produces a strong synergetic effect by H2S-induced inhibition of heat shock response, thereby effectively inhibiting tumor growth. Moreover, high intratumoral accumulation of the Pd-Su nanomedicine after intravenous injection also enables photothermal/photoacoustic dual-mode imaging-guided tumor treatment. Conclusions The proposed NIR-responsive heat/H2S release strategy provides a new approach for effective cancer therapy. Graphic abstract

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