Facile Synthesis of Lactobionic Acid-Targeted Iron Oxide Nanoparticles with Ultrahigh Relaxivity for Targeted MR Imaging of an Orthotopic Model of Human Hepatocellular Carcinoma

2016 ◽  
Vol 34 (1) ◽  
pp. 1600113 ◽  
Author(s):  
Yong Hu ◽  
Ruizhi Wang ◽  
Jingchao Li ◽  
Ling Ding ◽  
Xiaolin Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Iron Oxide ◽  
Mr Imaging ◽  
Iron Oxide Nanoparticles ◽  
Human Hepatocellular Carcinoma ◽  
Oxide Nanoparticles ◽  
Facile Synthesis ◽  
Orthotopic Model ◽  
Lactobionic Acid

Facile synthesis of folic acid-functionalized iron oxide nanoparticles with ultrahigh relaxivity for targeted tumor MR imaging

2015 ◽  
Vol 3 (28) ◽  
pp. 5720-5730 ◽  
Author(s):  
Jingchao Li ◽  
Yong Hu ◽  
Jia Yang ◽  
Wenjie Sun ◽  
Hongdong Cai ◽  
...  
Keyword(s):  
Folic Acid ◽  
Iron Oxide ◽  
Mr Imaging ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Facile Synthesis

Folic acid-functionalized iron oxide nanoparticles with an ultrahigh r2 relaxivity can be formed for targeted MR imaging of tumors.

Facile Synthesis of Folic Acid-Modified Iron Oxide Nanoparticles for Targeted MR Imaging in Pulmonary Tumor Xenografts

2015 ◽  
Vol 18 (4) ◽  
pp. 569-578 ◽  
Author(s):  
Zaixian Zhang ◽  
Yong Hu ◽  
Jia Yang ◽  
Yanhong Xu ◽  
Chengzhong Zhang ◽  
...  
Keyword(s):  
Folic Acid ◽  
Iron Oxide ◽  
Mr Imaging ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Facile Synthesis ◽  
Tumor Xenografts ◽  
Pulmonary Tumor

Facile synthesis of RGD peptide-modified iron oxide nanoparticles with ultrahigh relaxivity for targeted MR imaging of tumors

2015 ◽  
Vol 3 (5) ◽  
pp. 721-732 ◽  
Author(s):  
Yong Hu ◽  
Jingchao Li ◽  
Jia Yang ◽  
Ping Wei ◽  
Yu Luo ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Iron Oxide Nanoparticles ◽  
Rgd Peptide ◽  
Oxide Nanoparticles ◽  
Facile Synthesis

RGD peptide-functionalized iron oxide nanoparticles with ultrahigh relaxivity can be synthesized for targeted MR imaging of αvβ3 integrin-overexpressing tumors.

scholarly journals Macrophage-Laden Gold Nanoflowers Embedded with Ultrasmall Iron Oxide Nanoparticles for Enhanced Dual-Mode CT/MR Imaging of Tumors

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 995
Author(s):  
Yucheng Peng ◽  
Xiaomeng Wang ◽  
Yue Wang ◽  
Yue Gao ◽  
Rui Guo ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Iron Oxide Nanoparticles ◽  
Colloidal Stability ◽  
Pamam Dendrimer ◽  
Great Promise ◽  
Oxide Nanoparticles ◽  
Dual Mode ◽  
Gold Nanoflowers ◽  
Average Size

The design of multimodal imaging nanoplatforms with improved tumor accumulation represents a major trend in the current development of precision nanomedicine. To this end, we report herein the preparation of macrophage (MA)-laden gold nanoflowers (NFs) embedded with ultrasmall iron oxide nanoparticles (USIO NPs) for enhanced dual-mode computed tomography (CT) and magnetic resonance (MR) imaging of tumors. In this work, generation 5 poly(amidoamine) (G5 PAMAM) dendrimer-stabilized gold (Au) NPs were conjugated with sodium citrate-stabilized USIO NPs to form hybrid seed particles for the subsequent growth of Au nanoflowers (NFs). Afterwards, the remaining terminal amines of dendrimers were acetylated to form the dendrimer-stabilized Fe3O4/Au NFs (for short, Fe3O4/Au DSNFs). The acquired Fe3O4/Au DSNFs possess an average size around 90 nm, display a high r1 relaxivity (1.22 mM−1 s−1), and exhibit good colloidal stability and cytocompatibility. The created hybrid DSNFs can be loaded within MAs without producing any toxicity to the cells. Through the mediation of MAs with a tumor homing and immune evasion property, the Fe3O4/Au DSNFs can be delivered to tumors more efficiently than those without MAs after intravenous injection, thus significantly improving the MR/CT imaging performance of tumors. The developed MA-mediated delivery system may hold great promise for enhanced tumor delivery of other contrast agents or nanomedicines for precision cancer nanomedicine applications.

LAPONITE®-stabilized iron oxide nanoparticles for in vivo MR imaging of tumors

2016 ◽  
Vol 4 (3) ◽  
pp. 474-482 ◽  
Author(s):  
Ling Ding ◽  
Yong Hu ◽  
Yu Luo ◽  
Jianzhi Zhu ◽  
Yilun Wu ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Iron Oxide Nanoparticles ◽  
Colloidal Stability ◽  
Coprecipitation Method ◽  
Oxide Nanoparticles

LAPONITE®-stabilized iron oxide nanoparticles with great colloidal stability and high T2 relaxivity are synthesized by a facile controlled coprecipitation method, and can significantly enhance the contrast of tumors in vivo, indicating their tremendous potential in MR imaging applications.

Facile Synthesis of Well-dispersed Hollow Mesoporous Silica Nanoparticles Using Iron Oxide Nanoparticles as Template

2013 ◽  
Vol 42 (3) ◽  
pp. 316-317 ◽  
Author(s):  
Takaaki Ikuno ◽  
Atsuro Nomura ◽  
Kenta Iyoki ◽  
Ayae Sugawara-Narutaki ◽  
Tatsuya Okubo ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Oxide Nanoparticles ◽  
Facile Synthesis ◽  
Hollow Mesoporous Silica

scholarly journals Intrinsically Germanium-69-Labeled Iron Oxide Nanoparticles: Synthesis and In-Vivo Dual-Modality PET/MR Imaging

2014 ◽  
Vol 26 (30) ◽  
pp. 5119-5123 ◽  
Author(s):  
Rubel Chakravarty ◽  
Hector F. Valdovinos ◽  
Feng Chen ◽  
Christina M. Lewis ◽  
Paul A. Ellison ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Dual Modality ◽  
Nanoparticles Synthesis

Targeted CT/MR dual mode imaging of human hepatocellular carcinoma using lactobionic acid-modified polyethyleneimine-entrapped gold nanoparticles

2017 ◽  
Vol 5 (13) ◽  
pp. 2395-2401 ◽  
Author(s):  
Du Li ◽  
Jia Yang ◽  
Shihui Wen ◽  
Mingwu Shen ◽  
Linfeng Zheng ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gold Nanoparticles ◽  
Mr Imaging ◽  
Human Hepatocellular Carcinoma ◽  
Dual Mode ◽  
Lactobionic Acid

Multifunctional PEI-entrapped gold nanoparticles modified with lactobionic acid enable efficient targeted dual mode CT/MR imaging of human hepatocellular carcinoma.

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