Human-Serum-Albumin-Coated Prussian Blue Nanoparticles as pH-/Thermotriggered Drug-Delivery Vehicles for Cancer Thermochemotherapy

2015 ◽  
Vol 33 (1) ◽  
pp. 53-62 ◽  
Author(s):  
Zhenglin Li ◽  
Ying Hu ◽  
Tingting Jiang ◽  
Kenneth A. Howard ◽  
Yonggang Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Prussian Blue ◽  
Drug Delivery Vehicles ◽  
Prussian Blue Nanoparticles ◽  
Delivery Vehicles

Paclitaxel modified Fe3O4 loaded albumin nanoparticles as drug delivery vehicles by self-assembly

RSC Advances ◽  
2016 ◽  
Vol 6 (49) ◽  
pp. 43284-43292 ◽  
Author(s):  
Xiang-long Tang ◽  
Ben-lan Lin ◽  
Sheng Cui ◽  
Xin Zhang ◽  
Yang Zhong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Self Assembly ◽  
Drug Delivery Vehicles ◽  
Albumin Nanoparticles ◽  
Assembly Method ◽  
Delivery Vehicles

Paclitaxel (PTX) modified superparamagnetic Fe3O4 nanoparticles (Fe3O4/PTX NPs) are obtained and then Fe3O4/PTX NPs are loaded into human serum albumin (HSA) to form novel Fe3O4/PTX/HSA NPs with pie structure by self-assembly method.

scholarly journals Facile synthesis of Prussian blue nanoparticles as pH-responsive drug carriers for combined photothermal-chemo treatment of cancer

RSC Advances ◽  
2017 ◽  
Vol 7 (1) ◽  
pp. 248-255 ◽  
Author(s):  
Huajian Chen ◽  
Yan Ma ◽  
Xianwen Wang ◽  
Xiaoyi Wu ◽  
Zhengbao Zha
Keyword(s):  
Drug Delivery ◽  
Prussian Blue ◽  
Cancer Cells ◽  
Drug Carriers ◽  
High Efficacy ◽  
Ph Responsive ◽  
Facile Synthesis ◽  
Drug Delivery Vehicles ◽  
Prussian Blue Nanoparticles ◽  
Delivery Vehicles

Multifunctional PEGylated PB-DOX NPs with a lipid-PEG shell were developed as a gram-scale manner and used as novel pH-responsive drug delivery vehicles for combined photothermal-chemo treatment of cancer cells with high efficacy.

Non-toxic sonochemical synthesis of surface functionalized human serum albumin nanocapsules for targeted drug delivery

2012 ◽  
Vol 29 ◽  
pp. S228
Author(s):  
A. Rollett ◽  
T. Reiter ◽  
P. Nogueira ◽  
M. Cardinale ◽  
A. Loureiro ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Targeted Drug Delivery ◽  
Sonochemical Synthesis ◽  
Targeted Drug

Dual-Crosslinked Human Serum Albumin-Polymer Hydrogels for Affinity-Based Drug Delivery

2017 ◽  
Vol 302 (10) ◽  
pp. 1700243 ◽  
Author(s):  
Willem E. M. Noteborn ◽  
Yue Gao ◽  
Wim Jesse ◽  
Alexander Kros ◽  
Roxanne E. Kieltyka
Keyword(s):  
Drug Delivery ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Polymer Hydrogels

Characterization and side effect analysis of a newly designed nanoemulsion targeting human serum albumin for drug delivery

2012 ◽  
Vol 98 ◽  
pp. 80-84 ◽  
Author(s):  
Adeleh Divsalar ◽  
Ali Akbar Saboury ◽  
Mohammad Nabiuni ◽  
Zohre Zare ◽  
Mohammad Esmaeil Kefayati ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Side Effect ◽  
Effect Analysis

scholarly journals Recent Advancements in Serum Albumin-Based Nanovehicles Toward Potential Cancer Diagnosis and Therapy

2021 ◽  
Vol 9 ◽  
Author(s):  
Xue Shen ◽  
Xiyang Liu ◽  
Tingting Li ◽  
Yin Chen ◽  
Yang Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Serum Albumin ◽  
Cancer Diagnosis ◽  
Drug Loading ◽  
Essential Information ◽  
Drug Delivery Vehicles ◽  
Albumin Nanoparticles ◽  
Diagnosis And Therapy ◽  
Delivery Vehicles ◽  
Cancer Diagnosis And Therapy

Recently, drug delivery vehicles based on nanotechnology have significantly attracted the attention of researchers in the field of nanomedicine since they can achieve ideal drug release and biodistribution. Among the various organic or inorganic materials that used to prepare drug delivery vehicles for effective cancer treatment, serum albumin-based nanovehicles have been widely developed and investigated due to their prominent superiorities, including good biocompatibility, high stability, nontoxicity, non-immunogenicity, easy preparation, and functionalization, allowing them to be promising candidates for cancer diagnosis and therapy. This article reviews the recent advances on the applications of serum albumin-based nanovehicles in cancer diagnosis and therapy. We first introduce the essential information of bovine serum albumin (BSA) and human serum albumin (HSA), and discuss their drug loading strategies. We then discuss the different types of serum albumin-based nanovehicles including albumin nanoparticles, surface-functionalized albumin nanoparticles, and albumin nanocomplexes. Moreover, after briefly discussing the application of serum albumin-based nanovehicles used as the nanoprobes in cancer diagnosis, we also describe the serum albumin-based nanovehicle-assisted cancer theranostics, involving gas therapy, chemodynamic therapy (CDT), phototherapy (PTT/PDT), sonodynamic therapy (SDT), and other therapies as well as cancer imaging. Numerous studies cited in our review show that serum albumin-based nanovehicles possess a great potential in cancer diagnostic and therapeutic applications.

Human Serum Albumin Nanoparticles as a Carrier for On-Demand Sorafenib Delivery

2021 ◽  
Vol 22 ◽  
Author(s):  
Tania Caputo ◽  
Angela Maria Cusano ◽  
Menotti Ruvo ◽  
Anna Aliberti ◽  
Andrea Cusano
Keyword(s):  
Drug Delivery ◽  
Human Serum Albumin ◽  
Drug Release ◽  
Serum Albumin ◽  
Human Serum ◽  
Encapsulation Efficiency ◽  
Kinase Inhibitor ◽  
Force Microscopy ◽  
Atomic Force

Background: Drug delivery systems based on Human Serum Albumin (HSA) have been widely investigated due to their capability to interact with several molecules together with their nontoxicity, non-immunogenicity and biocompatibility. Sorafenib (SOR) is a kinase inhibitor used as the first-line treatment in hepatic cancer. However, because of its several intrinsic drawbacks (low solubility and bioavailability), there is a growing need for discovering new carriers able to overcome the current limitations. Objective: To study HSA particles loaded with SOR as a thermal responsive drug delivery system. Method: A detailed spectroscopy analysis of the HSA and SOR interaction in solution was carried out in order to characterize the temperature dependence of the complex. Based on this study, the synthesis of HSA particles loaded with SOR was optimized. Particles were characterized by Dynamic Light Scattering, Atomic Force Microscopy and by spectrofluorometer. Encapsulation efficiency and in vitro drug release were quantified by RP-HPLC. Results: HSA particles were monodispersed in size (≈ 200 nm); encapsulation efficiency ranged from 25% to 58%. Drug release studies that were performed at 37 °C and 50 °C showed that HS5 particles achieved a drug release of 0.430 µM in 72 hours at 50 °C in PBS buffer, accomplishing a 4.6-fold overall SOR release enhancement following a temperature increase from 37 °C to 50 °C. Conclusion: The system herein presented has the potential to exert a therapeutic action (in the nM range) triggering a sustained temperature-controllable release of relevant drugs.

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