scholarly journals Biodeactivation of Lipopolysaccharide Correlates with Surface-Bound NO3After Cold Atmospheric Plasma Treatment

2015 ◽  
Vol 13 (4) ◽  
pp. 410-418 ◽  
Author(s):  
Elliot A. J. Bartis ◽  
Pingshan Luan ◽  
Andrew J. Knoll ◽  
David B. Graves ◽  
Joonil Seog ◽  
...  
Keyword(s):  
Plasma Treatment ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma

Cold atmospheric plasma treatment for diaper dermatitis: A case report

2021 ◽  
Author(s):  
Chenchen Zhang ◽  
Jun Zhao ◽  
Yamei Gao ◽  
Jing Gao ◽  
Yongmei Lv
Keyword(s):  
Case Report ◽  
Plasma Treatment ◽  
Atmospheric Plasma ◽  
Diaper Dermatitis ◽  
Cold Atmospheric Plasma

scholarly journals Cold atmospheric plasma treatment selectively targets head and neck squamous cell carcinoma cells

2014 ◽  
Vol 34 (4) ◽  
pp. 941-946 ◽  
Author(s):  
RAFAEL GUERRERO-PRESTON ◽  
TAKENORI OGAWA ◽  
MAMORU UEMURA ◽  
GARY SHUMULINSKY ◽  
BLANCA L. VALLE ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Plasma Treatment ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Carcinoma Cells ◽  
Neck Squamous Cell Carcinoma ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma

Cold atmospheric plasma treatment inhibits growth in colorectal cancer cells

2018 ◽  
Vol 400 (1) ◽  
pp. 111-122 ◽  
Author(s):  
Christin Schneider ◽  
Stephanie Arndt ◽  
Julia L. Zimmermann ◽  
Yangfang Li ◽  
Sigrid Karrer ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Plasma Treatment ◽  
Cancer Cells ◽  
Ex Vivo ◽  
Atmospheric Plasma ◽  
Normal Colon ◽  
Colon Tissue ◽  
Cold Atmospheric Plasma ◽  
Colorectal Cancer Cells

AbstractPlasma oncology is a relatively new field of research. Recent developments have indicated that cold atmospheric plasma (CAP) technology is an interesting new therapeutic approach to cancer treatment. In this study, p53 wildtype (LoVo) and human p53 mutated (HT29 and SW480) colorectal cancer cells were treated with the miniFlatPlaSter – a device particularly developed for the treatment of tumor cells – that uses the Surface Micro Discharge (SMD) technology for plasma production in air. The present study analyzed the effects of plasma on colorectal cancer cellsin vitroand on normal colon tissueex vivo. Plasma treatment had strong effects on colon cancer cells, such as inhibition of cell proliferation, induction of cell death and modulation of p21 expression. In contrast, CAP treatment of murine colon tissueex vivofor up to 2 min did not show any toxic effect on normal colon cells compared to H2O2positive control. In summary, these results suggest that the miniFlatPlaSter plasma device is able to kill colorectal cancer cells independent of their p53 mutation status. Thus, this device presents a promising new approach in colon cancer therapy.

A holistic study to understand the detoxification of mycotoxins in maize and impact on its molecular integrity using cold atmospheric plasma treatment

2019 ◽  
Vol 301 ◽  
pp. 125281 ◽  
Author(s):  
Ewa Wielogorska ◽  
Yusuf Ahmed ◽  
Julie Meneely ◽  
William G. Graham ◽  
Christopher T. Elliott ◽  
...  
Keyword(s):  
Plasma Treatment ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma

Development of simultaneous substrate mixer and cold atmospheric plasma treatment for mushroom cultivation

2020 ◽  
Author(s):  
N. Redzuan ◽  
M. R. Rabbi ◽  
L. Agun ◽  
N. Ahmad ◽  
K. Zakaria ◽  
...  
Keyword(s):  
Plasma Treatment ◽  
Atmospheric Plasma ◽  
Mushroom Cultivation ◽  
Cold Atmospheric Plasma

scholarly journals Cold Atmospheric Plasma induces accumulation of lysosomes and caspase-independent cell death in U373MG glioblastoma multiforme cells

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Gillian E. Conway ◽  
Zhonglei He ◽  
Ana Lacramioara Hutanu ◽  
George Paul Cribaro ◽  
Eline Manaloto ◽  
...  
Keyword(s):  
Cell Death ◽  
Glioblastoma Multiforme ◽  
Plasma Treatment ◽  
Acridine Orange ◽  
Molecular Mechanisms ◽  
Confocal Imaging ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma ◽  
Rapid Accumulation ◽  
Lysosomal Accumulation

Abstract Room temperature Cold Atmospheric Plasma (CAP) has shown promising efficacy for the treatment of cancer but the exact mechanisms of action remain unclear. Both apoptosis and necrosis have been implicated as the mode of cell death in various cancer cells. We have previously demonstrated a caspase-independent mechanism of cell death in p53-mutated glioblastoma multiforme (GBM) cells exposed to plasma. The purpose of this study was to elucidate the molecular mechanisms involved in caspase-independent cell death induced by plasma treatment. We demonstrate that plasma induces rapid cell death in GBM cells, independent of caspases. Accumulation of vesicles was observed in plasma treated cells that stained positive with acridine orange. Western immunoblotting confirmed that autophagy is not activated following plasma treatment. Acridine orange intensity correlates closely with the lysosomal marker Lyso TrackerTM Deep Red. Further investigation using isosurface visualisation of confocal imaging confirmed that lysosomal accumulation occurs in plasma treated cells. The accumulation of lysosomes was associated with concomitant cell death following plasma treatment. In conclusion, we observed rapid accumulation of acidic vesicles and cell death following CAP treatment in GBM cells. We found no evidence that either apoptosis or autophagy, however, determined that a rapid accumulation of late stage endosomes/lysosomes precedes membrane permeabilisation, mitochondrial membrane depolarisation and caspase independent cell death.

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