Depression in Men Receiving Androgen Deprivation Therapy for Prostate Cancer: A Pilot Study

2002 ◽  
Vol 11 (6) ◽  
pp. 518-523 ◽  
Author(s):  
William F. Pirl ◽  
Gabrielle I. Siegel ◽  
Melissa J. Goode ◽  
Matthew R. Smith
Keyword(s):  
Prostate Cancer ◽  
Pilot Study ◽  
Androgen Deprivation Therapy ◽  
Androgen Deprivation

A pilot study of the effects of androgen deprivation therapy on physical function and comprehensive geriatric health in older men with prostate cancer.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e16510-e16510
Author(s):  
Elizabeth Riley Kessler ◽  
Thomas W. Flaig ◽  
Elaine Tat Lam ◽  
Kathryn M. Breaker ◽  
Michael Wacker ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Pilot Study ◽  
Physical Function ◽  
Androgen Deprivation Therapy ◽  
Older Patients ◽  
Treatment Initiation ◽  
Locally Advanced ◽  
Older Men ◽  
Androgen Deprivation ◽  
Health Improvement

e16510 Background: Alteration of the androgen axis through androgen deprivation therapy (ADT) is the mainstay of prostate cancer (PCa) treatment. Unfortunately, the resultant hypogonadal state has detrimental effects on muscle and bone and may impair physical function (PF). Older patients may be more vulnerable to PF changes while on ADT. We conducted a pilot study to evaluate the changes in PF and geriatric health in older men initiating ADT using tests easily employed in routine clinical practice. Methods: Men with PCa initiating ADT were enrolled and were assessed every 3 months (mos) for up to 12 mos. PF was measured using the short physical performance battery (SPPB) and geriatric health was screened using the Vulnerable Elders Survey (VES13) which predicts potential death or decline over 2 years. The primary endpoint was change in SPPB and VES13 at 3 mos. Results: We enrolled 17 patients with a median age of 75 years (range 67-85) beginning ADT therapy. Fourteen patients had metastasis, 2 had locally advanced disease, and 1 had biochemical recurrence. The majority had Gleason score (GS) 7 cancer (9/17), 7/17 GS 8-10, and 1/17 with GS 6. Eight patients had normal SPPB baseline scores and 9 had moderate impairment (moderate frailty risk) (Mean 10, SD 1.71). Seven had a clinically significant decline in the SPPB at 3 mos, with 1 patient testing as severely impaired. The VES13 screening tool identified 6/17 patients as vulnerable at baseline (Mean 3, SD 3.92). At 3 months, 3/17 patients had a decline in VES13 and 6/17 with an improvement. Of the 10 patients who were followed for at least 6 months, 5 had worsening of the VES13 and 2 had a worsening in SPPB. Conclusions: Older patients initiating ADT have baseline vulnerabilities in geriatric health with little immediate detriment after treatment initiation, perhaps due to overall health improvement with treatment initiation. Changes in PF, however, are seen within the first 3 months of ADT in nearly half of our patients, warranting further investigation into early rehabilitation of men even on short-term ADT. The SPPB is easily employed in clinic and important as reliance on VES13 alone is likely to miss patients with PF impairments.

scholarly journals Computerized cognitive training in prostate cancer patients on androgen deprivation therapy: a pilot study

2017 ◽  
Vol 26 (6) ◽  
pp. 1917-1926 ◽  
Author(s):  
Lisa M. Wu ◽  
Ali Amidi ◽  
Molly L. Tanenbaum ◽  
Gary Winkel ◽  
Wayne A. Gordon ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Pilot Study ◽  
Cancer Patients ◽  
Androgen Deprivation Therapy ◽  
Cognitive Training ◽  
Androgen Deprivation ◽  
Computerized Cognitive Training

scholarly journals Prostate Cancer in Elderly Croatian Men: 5-HT Genetic Polymorphisms and the Influence of Androgen Deprivation Therapy on Osteopenia—A Pilot Study

2012 ◽  
Vol 16 (6) ◽  
pp. 598-604 ◽  
Author(s):  
Daria Pašalić ◽  
Paulina Pauković ◽  
Selma Cvijetić ◽  
Alica Pizent ◽  
Jasna Jurasović ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Pilot Study ◽  
Genetic Polymorphisms ◽  
Androgen Deprivation Therapy ◽  
Androgen Deprivation
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