scholarly journals Phase behavior and viscoelastic properties of entangled block copolymer gels

2001 ◽  
Vol 39 (18) ◽  
pp. 2183-2197 ◽  
Author(s):  
Daniel A. Vega ◽  
John M. Sebastian ◽  
Yueh-Lin Loo ◽  
Richard A. Register
2008 ◽  
Vol 64 (a1) ◽  
pp. C146-C146
Author(s):  
P. Thiyagarajan ◽  
V. Pol ◽  
D. Bohnsack ◽  
C.-T. Lo ◽  
B. Lee ◽  
...  

1999 ◽  
Vol 32 (3) ◽  
pp. 637-645 ◽  
Author(s):  
Mårten Svensson ◽  
Paschalis Alexandridis ◽  
Per Linse

2001 ◽  
Vol 34 (25) ◽  
pp. 8701-8709 ◽  
Author(s):  
Hyeok Hahn ◽  
Joon H. Lee ◽  
Nitash P. Balsara ◽  
Bruce A. Garetz ◽  
Hiroshi Watanabe

2008 ◽  
pp. 391-417 ◽  
Author(s):  
Carlos Rodrguez ◽  
Arturo Lpez-Quintela ◽  
Md. Hemayet Uddin ◽  
Kenji Aramaki ◽  
Hironobu Kunieda

2020 ◽  
Vol 12 (51) ◽  
pp. 57421-57430
Author(s):  
Michael D. Galluzzo ◽  
Whitney S. Loo ◽  
Eric Schaible ◽  
Chenhui Zhu ◽  
Nitash P. Balsara

1998 ◽  
Vol 108 (7) ◽  
pp. 2989-3000 ◽  
Author(s):  
Wayne W. Maurer ◽  
Frank S. Bates ◽  
Timothy P. Lodge ◽  
Kristoffer Almdal ◽  
Kell Mortensen ◽  
...  

2019 ◽  
Vol 116 (35) ◽  
pp. 17330-17335 ◽  
Author(s):  
Lian Zhu ◽  
Tiffany M. Richardson ◽  
Ludivine Wacheul ◽  
Ming-Tzo Wei ◽  
Marina Feric ◽  
...  

The nucleolus is a prominent nuclear condensate that plays a central role in ribosome biogenesis by facilitating the transcription and processing of nascent ribosomal RNA (rRNA). A number of studies have highlighted the active viscoelastic nature of the nucleolus, whose material properties and phase behavior are a consequence of underlying molecular interactions. However, the ways in which the material properties of the nucleolus impact its function in rRNA biogenesis are not understood. Here we utilize the Cry2olig optogenetic system to modulate the viscoelastic properties of the nucleolus. We show that above a threshold concentration of Cry2olig protein, the nucleolus can be gelled into a tightly linked, low mobility meshwork. Gelled nucleoli no longer coalesce and relax into spheres but nonetheless permit continued internal molecular mobility of small proteins. These changes in nucleolar material properties manifest in specific alterations in rRNA processing steps, including a buildup of larger rRNA precursors and a depletion of smaller rRNA precursors. We propose that the flux of processed rRNA may be actively tuned by the cell through modulating nucleolar material properties, which suggests the potential of materials-based approaches for therapeutic intervention in ribosomopathies.


CrystEngComm ◽  
2015 ◽  
Vol 17 (36) ◽  
pp. 6901-6913 ◽  
Author(s):  
Doreen Hentrich ◽  
Mathias Junginger ◽  
Michael Bruns ◽  
Hans G. Börner ◽  
Jessica Brandt ◽  
...  

The phase behavior of an amphiphilic block copolymer based on a poly(aspartic acid) hydrophilic block and a poly(n-butyl acrylate) hydrophobic block was investigated at the air–water and air–buffer interface.


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