Multidimensional mass spectrometry to characterize degradation products generated during MALDI of polystyrenes prepared by controlled radical polymerization techniques

2016 ◽  
Vol 54 (20) ◽  
pp. 3388-3397 ◽  
Author(s):  
Christophe Chendo ◽  
Dao Le ◽  
Trang N. T. Phan ◽  
Didier Gigmes ◽  
Laurence Charles
Keyword(s):  
Mass Spectrometry ◽  
Radical Polymerization ◽  
Degradation Products ◽  
Controlled Radical Polymerization ◽  
Multidimensional Mass Spectrometry

Controlled radical polymerization of hydrophilic and zwitterionic brush-like polymers from silk fibroin surfaces

2020 ◽  
Vol 8 (45) ◽  
pp. 10392-10406
Author(s):  
Danielle L. Heichel ◽  
Ngoc Chau H. Vy ◽  
Shawn P. Ward ◽  
Douglas H. Adamson ◽  
Kelly A. Burke
Keyword(s):  
Protein Adsorption ◽  
Radical Polymerization ◽  
Silk Fibroin ◽  
Cell Attachment ◽  
Controlled Radical Polymerization

Silk fibroin films were modified with zwitterionic and hydrophilic brush-like polymers via surface-initiated ATRP, resulting in surfaces that reduced protein adsorption and cell attachment.

Bacterial Redox Potential Powers Controlled Radical Polymerization

2020 ◽  
Author(s):  
Mitchell D. Nothling ◽  
Hanwei Cao ◽  
Thomas G. McKenzie ◽  
Dianna M. Hocking ◽  
Richard A. Strugnell ◽  
...  
Keyword(s):  
Redox Potential ◽  
Radical Polymerization ◽  
Controlled Radical Polymerization

scholarly journals Characterization and Study on Fragmentation Pathways of a Novel Nerve Agent, ‘Novichok (A234)’, in Aqueous Solution by Liquid Chromatography–Tandem Mass Spectrometry

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 1059
Author(s):  
Jin Young Lee ◽  
Kyoung Chan Lim ◽  
Hyun Suk Kim
Keyword(s):  
Mass Spectrometry ◽  
Aqueous Solution ◽  
Liquid Chromatography ◽  
Degradation Products ◽  
Aqueous Sample ◽  
Tandem Mass ◽  
Aqueous Samples ◽  
Fragmentation Pathways ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass

As a first step toward studying the properties of Novichok (ethyl (1-(diethylamino)ethylidene)phosphoramidofluoridate (A234)), we investigated its degradation products and fragmentation pathways in aqueous solution at different pH levels by liquid chromatography–tandem mass spectrometry. A234 was synthesized in our laboratory and characterized by nuclear magnetic resonance spectroscopy. Three sets of aqueous samples were prepared at different pH levels. A stock solution of A234 was prepared in acetonitrile at a concentration of 1 mg/mL and stored at −20 °C until use. Aqueous samples (0.1 mg/mL) were prepared by diluting the stock solution with deionized water. The acidic aqueous sample (pH = 3.5) and basic aqueous sample (pH = 9.4) were prepared using 0.01 M acetic acid and 0.01 M potassium carbonate, respectively. The analysis of the fragmentation patterns and degradation pathways of A234 showed that the same degradation products were formed at all pH levels. However, the hydrolysis rate of A234 was fastest under acidic conditions. In all three conditions, the fragmentation pattern and the major degradation product of A234 were determined. This information will be applicable to studies regarding the decontamination of Novichok and the trace analysis of its degradation products in various environmental matrices.

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