Controlled synthesis of amphiphilic block copolymers based on poly(isobutylene) macromonomers

2015 ◽  
Vol 54 (5) ◽  
pp. 634-643 ◽  
Author(s):  
Edward L. Malins ◽  
Carl Waterson ◽  
C. Remzi Becer
Keyword(s):  
Block Copolymers ◽  
Amphiphilic Block Copolymers ◽  
Controlled Synthesis

scholarly journals Synthesis of Fluorinated Amphiphilic Block Copolymers Based on PEGMA, HEMA, and MMA via ATRP and CuAAC Click Chemistry

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Fatime Eren Erol ◽  
Deniz Sinirlioglu ◽  
Sedat Cosgun ◽  
Ali Ekrem Muftuoglu
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Amphiphilic Block Copolymers ◽  
Random Copolymers ◽  
Side Chain ◽  
Dipolar Cycloaddition ◽  
Controlled Synthesis ◽  
H Nmr ◽  
Ft Ir ◽  
Click Coupling

Synthesis of fluorinated amphiphilic block copolymers via atom transfer radical polymerization (ATRP) and Cu(I) catalyzed Huisgen 1,3-dipolar cycloaddition (CuAAC) was demonstrated. First, a PEGMA and MMA based block copolymer carrying multiple side-chain acetylene moieties on the hydrophobic segment for postfunctionalization was carried out. This involves the synthesis of a series of P(HEMA-co-MMA) random copolymers to be employed as macroinitiators in the controlled synthesis of P(HEMA-co-MMA)-block-PPEGMA block copolymers by using ATRP, followed by a modification step on the hydroxyl side groups of HEMA via Steglich esterification to afford propargyl side-functional polymer, alkyne-P(HEMA-co-MMA)-block-PPEGMA. Finally, click coupling between side-chain acetylene functionalities and 2,3,4,5,6-pentafluorobenzyl azide yielded fluorinated amphiphilic block copolymers. The obtained polymers were structurally characterized by1H-NMR,19F-NMR, FT-IR, and GPC. Their thermal characterizations were performed using DSC and TGA.

scholarly journals Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances

2021 ◽  
Vol 9 (1) ◽  
pp. 38-50
Author(s):  
Hien Phan ◽  
Vincenzo Taresco ◽  
Jacques Penelle ◽  
Benoit Couturaud
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Amphiphilic Block Copolymers ◽  
Stimuli Responsive ◽  
Site Specific ◽  
On Demand ◽  
Redox Agents

Stimuli-responsive amphiphilic block copolymers obtained by PISA have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such as pH, redox agents, light or temperature.

Characterization of New Amphiphilic Block Copolymers of N-Vinylpyrrolidone and Vinyl Acetate, 2 - Chromatographic Separation and Analysis by MALDI-TOF and FT-IR Coupling

2010 ◽  
Vol 211 (15) ◽  
pp. 1678-1688 ◽  
Author(s):  
Nick Fandrich ◽  
Jana Falkenhagen ◽  
Steffen M. Weidner ◽  
Bastiaan Staal ◽  
Andreas F. Thünemann ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Vinyl Acetate ◽  
Chromatographic Separation ◽  
Amphiphilic Block Copolymers ◽  
Maldi Tof ◽  
Ft Ir
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