V-shaped graft copolymers via triple click reactions: Diels-alder, copper-catalyzed azide-alkyne cycloaddition, and nitroxide radical coupling

2013 ◽  
Vol 51 (21) ◽  
pp. 4667-4674 ◽  
Author(s):  
Ufuk Saim Gunay ◽  
Bengu Ozsoy ◽  
Hakan Durmaz ◽  
Gurkan Hizal ◽  
Umit Tunca
Keyword(s):  
Graft Copolymers ◽  
Nitroxide Radical ◽  
Diels Alder ◽  
Click Reactions ◽  
Radical Coupling

Synthesis of Thermal Degradable Poly(alkoxyamine) through a Novel Nitroxide Radical Coupling Step Growth Polymerization Mechanism

2014 ◽  
Vol 47 (22) ◽  
pp. 7812-7822 ◽  
Author(s):  
Xuepu Wang ◽  
Jian Huang ◽  
Lingdi Chen ◽  
Yujie Liu ◽  
Guowei Wang
Keyword(s):  
Nitroxide Radical ◽  
Polymerization Mechanism ◽  
Radical Coupling ◽  
Step Growth ◽  
Step Growth Polymerization

scholarly journals Micellar Carriers Based on Amphiphilic PEG/PCL Graft Copolymers for Delivery of Active Substances

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2876 ◽  
Author(s):  
Justyna Odrobińska ◽  
Dorota Neugebauer
Keyword(s):  
Molecular Weight ◽  
Graft Copolymers ◽  
Drug Loading ◽  
Polymer System ◽  
Amphiphilic Copolymers ◽  
Bioactive Substances ◽  
Click Reactions ◽  
Micellar Systems ◽  
Active Substances

Amphiphilic copolymers of alkyne functionalized 2-hydroxyethyl methacrylate (AlHEMA) and poly(ethylene glycol) methyl ether methacrylate (MPEGMA) with graft or V-shaped graft topologies were synthesized. The functionalization of poly(ε-caprolactone) (PCL) with azide group enabled attachment to P(AlHEMA-co-MPEGMA) copolymers via a “click” alkyne-azide reaction. The introduction of PCL as a second side chain type in addition to PEG resulted in heterografted copolymers with modified properties such as biodegradability. “Click” reactions were carried out with efficiencies between 17–70% or 32–50% (for lower molecular weight PCL, 4000 g/mol, or higher molecular weight PCL, 9000 g/mol, respectively) depending on the PEG grafting density. The graft copolymers were self-assembled into micellar superstructures with the ability to encapsulate active substances, such as vitamin C (VitC), arbutin (ARB) or 4-n-butylresorcinol (4nBRE). Drug loading contents (DLC) were obtained in the range of 5–55% (VitC), 39–91% (ARB) and 42–98% (4nBRE). In vitro studies carried out in a phosphate buffer saline (PBS) solution (at pH 7.4 or 5.5) gave the maximum release levels of active substances after 10–240 min depending on the polymer system. Permeation tests in Franz chambers indicated that the bioactive substances after release by micellar systems penetrated through the artificial skin membrane in small amounts, and a majority of the bioactive substances remained inside the membrane, which is satisfactory for most cosmetic applications.

Synthesis and characterization of amphiphilic triblock Copolymers with Identical compositions but different block sequences

RSC Advances ◽  
2014 ◽  
Vol 4 (82) ◽  
pp. 43682-43690 ◽  
Author(s):  
Chengjiao Lu ◽  
Lingdi Chen ◽  
Kun Huang ◽  
Guowei Wang
Keyword(s):  
Atom Transfer Radical Polymerization ◽  
Click Chemistry ◽  
Radical Polymerization ◽  
Triblock Copolymers ◽  
Coupling Reaction ◽  
Nitroxide Radical ◽  
Synthesis And Characterization ◽  
Radical Coupling ◽  
Radical Coupling Reaction

The amphiphilic triblock copolymers PAA-b-PS-b-PAA and PS-b-PAA-b-PS were synthesized by a combination of an atom transfer radical polymerization mechanism and a nitroxide radical coupling reaction or copper-catalyzed azide/alkyne click chemistry.

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