Preparation of miktoarm star-block copolymers PSn-b-PVAc4-n via combination of ATRP and RAFT polymerization

2010 ◽  
Vol 48 (22) ◽  
pp. 5180-5188 ◽  
Author(s):  
Yansheng Qiu ◽  
Wei Zhang ◽  
Yuefang Yan ◽  
Jian Zhu ◽  
Zhengbiao Zhang ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Raft Polymerization ◽  
Miktoarm Star ◽  
Star Block Copolymers

An easy way to the preparation of multi-miktoarm star block copolymers via sequential double click reactions

2010 ◽  
Vol 1 (5) ◽  
pp. 621 ◽  
Author(s):  
Aydan Dag ◽  
Hakan Durmaz ◽  
Volkan Kirmizi ◽  
Gurkan Hizal ◽  
Umit Tunca
Keyword(s):  
Block Copolymers ◽  
Click Reactions ◽  
Miktoarm Star ◽  
Star Block Copolymers

I5S Miktoarm Star Block Copolymers:  Packing Constraints on Morphology and Discontinuous Chevron Tilt Grain Boundaries

2001 ◽  
Vol 34 (26) ◽  
pp. 9069-9073 ◽  
Author(s):  
Lizhang Yang ◽  
Sheng Hong ◽  
Samuel P. Gido ◽  
Gabriel Velis ◽  
Nikos Hadjichristidis
Keyword(s):  
Block Copolymers ◽  
Grain Boundaries ◽  
Miktoarm Star ◽  
Star Block Copolymers

Star-Shaped Copolymers Based on Poly(N-vinylcaprolactam) and their Use as Nanocarriers of Methotrexate

2017 ◽  
Vol 70 (12) ◽  
pp. 1291 ◽  
Author(s):  
Norma A. Cortez-Lemus ◽  
Angel Licea-Claverie
Keyword(s):  
Polyethylene Glycol ◽  
Block Copolymers ◽  
Diblock Copolymers ◽  
Raft Polymerization ◽  
Drug Loading ◽  
Gel Permeation Chromatography ◽  
Solution Temperature ◽  
Star Copolymers ◽  
Vis Spectroscopy ◽  
Star Block Copolymers

Star-shaped poly(N-vinylcaprolactam)-block-poly(ethylhexylacrylate)-block-polyethylene glycol (PNVCL-b-PEHA-b-PEG) triblock copolymers and star-shaped poly(N-vinylcaprolactam)-block-polyethylene glycol (PNVCL-b-PEG) diblock copolymers were synthesized by reversible addition–fragmentation chain transfer (RAFT) polymerization. The resulting star block copolymers were characterized using 1H NMR and UV-vis spectroscopy, gel permeation chromatography, and dynamic light scattering. The star-shaped PNVCL-b-PEG and PNVCL-b-PEHA-b-PEG block copolymers self-assemble spontaneously into aggregates in water. The aggregates formed ranged from ~17 to 135 nm in diameter and were used to encapsulate methotrexate (MTX). It was observed that the aggregates from PNVCL-b-PEHA-b-PEG copolymers exhibited a higher drug loading and a lower release of MTX (19 wt-% and 54 %) as compared with star copolymers without PEHA (5 wt-% and 81 %) after 24 h at a temperature below their lower critical solution temperature values.

Biodegradable micelles self-assembled from miktoarm star block copolymers for MTX delivery

2015 ◽  
Vol 293 (8) ◽  
pp. 2291-2300 ◽  
Author(s):  
Qing-Han Zhou ◽  
Juan Lin ◽  
Li-Dong Li ◽  
Le Shang
Keyword(s):  
Block Copolymers ◽  
Miktoarm Star ◽  
Self Assembled ◽  
Star Block Copolymers

scholarly journals Preparation of Doxorubicin-Loaded Amphiphilic Poly(D,L-Lactide-Co-Glycolide)-b-Poly(N-Acryloylmorpholine) AB2 Miktoarm Star Block Copolymers for Anticancer Drug Delivery

Materials ◽  
2020 ◽  
Vol 13 (17) ◽  
pp. 3713
Author(s):  
Kalyan Ramesh ◽  
Avnish Kumar Mishra ◽  
Jin Kon Kim ◽  
Yeon Tae Jeong ◽  
Yeong-Soon Gal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Anticancer Drug ◽  
Polymeric Micelles ◽  
Drug Loading ◽  
Gel Permeation Chromatography ◽  
Critical Micellar Concentration ◽  
Anticancer Drug Delivery ◽  
Miktoarm Star ◽  
Star Block Copolymers

Owing to their unique topology and physical properties, micelles based on miktoarm amphiphilic star block copolymers play an important role in the biomedical field for drug delivery. Herein, we developed a series of AB2-type poly(D,L-lactide-co-glycolide)-b-poly(N-acryloyl morpholine) (PLGA-b-PNAM2) miktoarm star block copolymers by reversible addition–fragmentation chain–transfer polymerization and ring-opening copolymerization. The resulting miktoarm star polymers were investigated by 1H NMR spectroscopy and gel permeation chromatography. The critical micellar concentration value of the micelles increases with an increase in PNAM block length. As revealed by transmission electron microscopy and dynamic light scattering, the amphiphilic miktoarm star block copolymers can self-assemble to form spherical micellar aggregates in water. The anticancer drug doxorubicin (DOX) was encapsulated by polymeric micelles; the drug-loading efficiency and drug-loading content of the DOX-loaded micelles were 81.7% and 9.1%, respectively. Acidic environments triggered the dissociation of the polymeric micelles, which led to the more release of DOX in pH 6.4 than pH 7.4. The amphiphilic PLGA-b-PNAM2 miktoarm star block copolymers may have broad application as nanocarriers for controlled drug delivery.

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