Spectroscopic characterization and preparation of low molecular, water-soluble chitosan with free-amine group by novel method

2002 ◽  
Vol 40 (21) ◽  
pp. 3796-3803 ◽  
Author(s):  
Jae-Woon Nah ◽  
Mi-Kyeong Jang
Keyword(s):  
Spectroscopic Characterization ◽  
Water Soluble ◽  
Molecular Water ◽  
Amine Group ◽  
Free Amine ◽  
Free Amine Group ◽  
Novel Method

scholarly journals New Chloramphenicol Derivatives with a Modified Dichloroacetyl Tail as Potential Antimicrobial Agents

Antibiotics ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 394
Author(s):  
Artemis Tsirogianni ◽  
Georgia G. Kournoutou ◽  
Anthony Bougas ◽  
Eleni Poulou-Sidiropoulou ◽  
George Dinos ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Agents ◽  
Amine Group ◽  
Antibiotic Development ◽  
Beta Alanine ◽  
Free Amine ◽  
Free Amine Group ◽  
Amine Groups

To combat the dangerously increasing pathogenic resistance to antibiotics, we developed new pharmacophores by chemically modifying a known antibiotic, which remains to this day the most familiar and productive way for novel antibiotic development. We used as a starting material the chloramphenicol base, which is the free amine group counterpart of the known chloramphenicol molecule antibiotic upon removal of its dichloroacetyl tail. To this free amine group, we tethered alpha- and beta-amino acids, mainly glycine, lysine, histidine, ornithine and/or beta-alanine. Furthermore, we introduced additional modifications to the newly incorporated amine groups either with protecting groups triphenylmethyl- (Trt) and tert-butoxycarbonyl- (Boc) or with the dichloroacetic group found also in the chloramphenicol molecule. The antimicrobial activity of all compounds was tested both in vivo and in vitro, and according to the results, the bis-dichloroacetyl derivative of ornithine displayed the highest antimicrobial activity both in vivo and in vitro and seems to be a dynamic new pharmacophore with room for further modification and development.

Recent Advances of Chitosan and its Derivatives in Biomedical Applications

2020 ◽  
Vol 27 (18) ◽  
pp. 3023-3045 ◽  
Author(s):  
Fei Ding ◽  
Jiawei Fu ◽  
Chuang Tao ◽  
Yanhua Yu ◽  
Xianran He ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Future Research ◽  
Hydroxyl Groups ◽  
Amine Group ◽  
Research Directions ◽  
The Past ◽  
Free Amine ◽  
Natural Polysaccharide ◽  
Free Amine Group ◽  
Future Research Directions

Chitosan is the second-most abundant natural polysaccharide. It has unique characteristics, such as biodegradability, biocompatibility, and non-toxicity. Due to the existence of its free amine group and hydroxyl groups on its backbone chain, chitosan can undergo further chemical modifications to generate Chitosan Derivatives (CDs) that permit additional biomedical functionality. Chitosan and CDs can be fabricated into various forms, including Nanoparticles (NPs), micelles, hydrogels, nanocomposites and nano-chelates. For these reasons, chitosan and CDs have found a tremendous variety of biomedical applications in recent years. This paper mainly presents the prominent applications of chitosan and CDs for cancer therapy/diagnosis, molecule biosensing, viral infection, and tissue engineering over the past five years. Moreover, future research directions on chitosan are also considered.

scholarly journals Anion Recognition Via polarized –N-H Fragments

2018 ◽  
Vol 15 (2) ◽  
pp. 6311-6312
Author(s):  
Masood Ayoub Kaloo
Keyword(s):  
Analytical Chemistry ◽  
Anion Recognition ◽  
Organic Media ◽  
Amine Group ◽  
Hydrogen Bonding Interaction ◽  
Free Amine ◽  
Bonding Interaction ◽  
Free Amine Group ◽  
Anionic Species ◽  
Aqueous Conditions

Hydrogen bonding interaction and or proton transfer assets of synthetic molecules in presence of anionic species is pretty fascinating in the field of supramolecular analytical chemistry. Not only amide or urea based derivatives have appeared in the highlights, rather from last few decades, polarized free amine fragments (-NH2)   have been brought under the study with prompt signaling. In this report, I will be focusing on the basic aspects which trigger free amine group to decode rapid anion recognition not only under organic media, but also under aqueous conditions in diverse environments.

Synthesis, spectroscopic characterization, DFT studies, and antibacterial and antitumor activities of a novel water soluble Pd(II) complex with l-alliin

2013 ◽  
Vol 1035 ◽  
pp. 421-426 ◽  
Author(s):  
Camilla Abbehausen ◽  
Suelen F. Sucena ◽  
Marcelo Lancellotti ◽  
Tassiele A. Heinrich ◽  
Emiliana P. Abrão ◽  
...  
Keyword(s):  
Spectroscopic Characterization ◽  
Water Soluble ◽  
Dft Studies ◽  
Antitumor Activities

Micropatterned array to assess the interaction of single platelets with platelet factor 4-heparin-IgG complexes

2014 ◽  
Vol 111 (05) ◽  
pp. 862-872 ◽  
Author(s):  
Krystin Krauel ◽  
Nikolay Medvedev ◽  
Raghavendra Palankar ◽  
Andreas Greinacher ◽  
Mihaela Delcea
Keyword(s):  
Calcium Imaging ◽  
Cell Function ◽  
Platelet Factor 4 ◽  
Water Soluble ◽  
Cell Level ◽  
Platelet Factor ◽  
Ligand Density ◽  
Heparin Complexes ◽  
Novel Method ◽  
Platelet Aggregates

SummaryWe report a strategy to generate by electron beam lithography high fidelity micropatterned arrays to assess the interaction of single platelets with immobilised ligands. As a proof-of-principle we functionalised the microarrays with platelet factor 4 (PF4)-heparin-IgG complexes. We embedded biotinylated water-soluble quantum dots into polyethylene glycol (PEG)-coated micropatterned arrays and functionalised them via streptavidin to bind biotinylated ligands, here biotinylated-PF4/heparin complexes. The integrity of the PF4/heparin-complexes was shown by binding of anti-PF4/heparin antibodies. Ligand density was quantified by immunofluorescence and immunogold antibody labelling. Real-time calcium imaging was employed for read-out of single platelets activated on micropatterned surfaces functionalised with PF4/heparin-IgG complexes. With the smallest micropatterns (0.5x0.5 µm) we show that single platelets become strongly activated by binding to surface-immobilised PF4/heparin-IgG, while on larger micropatterns (10x10 µm), platelet aggregates formed. These findings that HIT antibodies can cause platelet activation on microarrays illustrate how this novel method opens new avenues to study platelet function at single cell level. Generating functionalized microarray surfaces to which highly complex ligands can be bound and quantified has the potential for platelet and other cell function assays integrated into high-throughput microfluidic microdevices.

Investigation of the Harmlessness of a High-Molecular Water-Soluble Polymer in Laboratory Animals

2021 ◽  
pp. 570-579
Author(s):  
Natalia Grudina ◽  
Vera Bydanova ◽  
Olga Izmestyeva ◽  
Nikolai Grudin
Keyword(s):  
Water Soluble ◽  
Laboratory Animals ◽  
Molecular Water ◽  
Soluble Polymer ◽  
Water Soluble Polymer

Retinol-encapsulated low molecular water-soluble chitosan nanoparticles

2006 ◽  
Vol 319 (1-2) ◽  
pp. 130-138 ◽  
Author(s):  
D KIM ◽  
Y JEONG ◽  
C CHOI ◽  
S ROH ◽  
S KANG ◽  
...  
Keyword(s):  
Chitosan Nanoparticles ◽  
Water Soluble ◽  
Molecular Water
Sign in / Sign up

Export Citation Format

Share Document