scholarly journals Efficacy of topical lidocaine‐prilocaine (EMLA ® ) for management of infant pain during pneumococcal vaccination: A randomized controlled trial

2021 ◽  
Author(s):  
Beatrice Olsson Duse ◽  
Ylva Sporrong ◽  
Marcco Bartocci ◽  
Karin Skoglund
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Pneumococcal Vaccination ◽  
Randomized Controlled ◽  
Topical Lidocaine ◽  
Infant Pain ◽  
Lidocaine Prilocaine

scholarly journals The impact of topical lidocaine and timing of LMA removal on the incidence of airway events during the recovery period in children: a randomized controlled trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ruiqiang Sun ◽  
Xiaoyun Bao ◽  
Xuesong Gao ◽  
Tong Li ◽  
Quan Wang ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Recovery Period ◽  
Awake State ◽  
Randomized Controlled ◽  
Laryngeal Spasm ◽  
Topical Lidocaine ◽  
Lubricant Application ◽  
Pacu Stay ◽  
The Impact

Abstract Background The timing of laryngeal mask airway (LMA) removal remains undefined. This study aimed to assess the optimal timing for LMA removal and whether topical anesthesia with lidocaine could reduce airway adverse events. Methods This randomized controlled trial assessed one-to-six-year-old children with ASA I-II scheduled for squint correction surgery under general anesthesia. The children were randomized into the LA (lidocaine cream smeared to the cuff of the LMA before insertion, with mask removal in the awake state), LD (lidocaine application and LMA removal under deep anesthesia), NLA (hydrosoluble lubricant application and LMA removal in the awake state) and NLD (hydrosoluble lubricant application and LMA removal in deep anesthesia) groups. The primary endpoint was a composite of irritating cough, laryngeal spasm, SpO2 < 96%, and glossocoma in the recovery period in the PACU. The secondary endpoints included the incidence of pharyngalgia and hoarseness within 24 h after the operation, duration of PACU stay, and incidence of agitation in the recovery period. The assessor was unblinded. Results Each group included 98 children. The overall incidence of adverse airway events was significantly lower in the LA group (9.4%) compared with the LD (23.7%), NLA (32.6%), and NLD (28.7%) groups (P=0.001). Cough and laryngeal spasm rates were significantly higher in the NLA group (20.0 and 9.5%, respectively) than the LA (5.2 and 0%, respectively), LD (4.1 and 1.0%, respectively), and NLD (9.6 and 2.1%, respectively) groups (P=0.001). Glossocoma incidence was significantly lower in the LA and NLA groups (0%) than in the LD (19.6%) and NLD (20.2%) groups (P< 0.001). At 24 h post-operation, pharyngalgia incidence was significantly higher in the NLA group (15.8%) than the LA (3.1%), LD (1.0%), and NLD (3.2%) groups (P< 0.001). Conclusions LMA removal in the awake state after topical lidocaine anesthesia reduces the incidence of postoperative airway events. Trial registration ChiCTR, ChiCTR-IPR-17012347. Registered August 12, 2017.

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