Proteomics reveals the potential mechanism of Mrps35 controlling Listeria monocytogenes intracellular proliferation in macrophages

PROTEOMICS ◽  
2021 ◽  
pp. 2000262
Author(s):  
Jiangbei Yuan ◽  
Zhangfu Li ◽  
Fang Li ◽  
Zewei Lin ◽  
Siyu Yao ◽  
...  
Keyword(s):  
Listeria Monocytogenes ◽  
Potential Mechanism ◽  
Intracellular Proliferation

scholarly journals CD44-Regulated Intracellular Proliferation of Listeria monocytogenes

2003 ◽  
Vol 71 (7) ◽  
pp. 4102-4111 ◽  
Author(s):  
Emma Eriksson ◽  
Lone Dons ◽  
Antonio Gigliotti Rothfuchs ◽  
Paraskevi Heldin ◽  
Hans Wigzell ◽  
...  
Keyword(s):  
Listeria Monocytogenes ◽  
Intracellular Growth ◽  
Murine Bone Marrow ◽  
Bacterial Proliferation ◽  
Serovar Typhimurium ◽  
Inflammatory Processes ◽  
And Control ◽  
Intracellular Proliferation ◽  
Hyaluronan Binding

ABSTRACT CD44 has been implicated in immune and inflammatory processes. We have analyzed the role of CD44 in the outcome of Listeria monocytogenes infection in murine bone marrow-derived macrophages (BMM). Surprisingly, a dramatically decreased intracellular survival of L. monocytogenes was observed in CD44−/− BMM. CD44−/− heart or lung fibroblast cultures also showed reduced bacterial levels. Moreover, livers from CD44−/−-infected mice showed diminished levels of L. monocytogenes. In contrast, intracellular growth of Salmonella enterica serovar Typhimurium was the same in CD44−/− and control BMM. The CD44-mediated increased bacterial proliferation was not linked to altered BMM differentiation or to secretion of soluble factors. CD44 did not mediate listerial uptake, and it played no role in bacterial escape from the primary phagosome or formation of actin tails. Furthermore, CD44-enhanced listerial proliferation occurred in the absence of intracellular bacterial spreading. Interestingly, coincubation of BMM with hyaluronidase or anti-CD44 antibodies that selectively inhibit hyaluronan binding increased intracellular listerial proliferation. Treatment of cells with hyaluronan, in contrast, diminished listerial growth and induced proinflammatory transcript levels. We suggest that L. monocytogenes takes advantage of the CD44-mediated signaling to proliferate intracellularly, although binding of CD44 to certain ligands will inhibit such response.

scholarly journals Defensins enable macrophages to inhibit the intracellular proliferation of Listeria monocytogenes

2011 ◽  
Vol 13 (4) ◽  
pp. 635-651 ◽  
Author(s):  
Eusondia Arnett ◽  
Robert I. Lehrer ◽  
Pratikhya Pratikhya ◽  
Wuyuan Lu ◽  
Stephanie Seveau
Keyword(s):  
Listeria Monocytogenes ◽  
Intracellular Proliferation

Emotional Impact Feedback Changes How We Remember Negative Autobiographical Experiences

2010 ◽  
Vol 57 (5) ◽  
pp. 354-359 ◽  
Author(s):  
Melanie K. T. Takarangi ◽  
Deryn Strange
Keyword(s):  
Well Being ◽  
The Other ◽  
Personal Perspective ◽  
Emotional Impact ◽  
Potential Mechanism ◽  
Negative Experiences ◽  
Negative Memory ◽  
The Relationship ◽  
Negative Memories ◽  
Over Time

When people are told that their negative memories are worse than other people’s, do they later remember those events differently? We asked participants to recall a recent negative memory then, 24 h later, we gave some participants feedback about the emotional impact of their event – stating it was more or less negative compared to other people’s experiences. One week later, participants recalled the event again. We predicted that if feedback affected how participants remembered their negative experiences, their ratings of the memory’s characteristics should change over time. That is, when participants are told that their negative event is extremely negative, their memories should be more vivid, recollected strongly, and remembered from a personal perspective, compared to participants in the other conditions. Our results provide support for this hypothesis. We suggest that external feedback might be a potential mechanism in the relationship between negative memories and psychological well-being.

Use of essential oil treatments to control the Listeria monocytogenes growth in various food commodities

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
NG Chorianopoulos ◽  
PN Skandamis ◽  
GJE Nychas ◽  
SA Haroutounian
Keyword(s):  
Listeria Monocytogenes ◽  
Essential Oil ◽  
Food Commodities

Low vitamin D is associated with increased bladder cancer risk; a systematic review and evidence of a potential mechanism

2016 ◽  
Author(s):  
Rosemary Bland ◽  
Corina Chivu ◽  
Kieran Jefferson ◽  
Donald MacDonald ◽  
Gulnaz Iqbal ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Bladder Cancer ◽  
Cancer Risk ◽  
Potential Mechanism ◽  
Bladder Cancer Risk
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