Liquid Biopsy Based Single‐Cell Transcriptome Profiling Characterizes Heterogeneity of Disseminated Tumor Cells from Lung Adenocarcinoma

PROTEOMICS ◽  
2020 ◽  
Vol 20 (13) ◽  
pp. 1900224 ◽  
Author(s):  
Yu Dong ◽  
Zhuo Wang ◽  
Qihui Shi
Keyword(s):  
Lung Adenocarcinoma ◽  
Single Cell ◽  
Tumor Cells ◽  
Liquid Biopsy ◽  
Transcriptome Profiling ◽  
Disseminated Tumor Cells ◽  
Cell Transcriptome ◽  
Single Cell Transcriptome

scholarly journals High-Throughput Single-Cell Transcriptome Profiling of Plant Cell Types

Cell Reports ◽  
2019 ◽  
Vol 27 (7) ◽  
pp. 2241-2247.e4 ◽  
Author(s):  
Christine N. Shulse ◽  
Benjamin J. Cole ◽  
Doina Ciobanu ◽  
Junyan Lin ◽  
Yuko Yoshinaga ◽  
...  
Keyword(s):  
Single Cell ◽  
Plant Cell ◽  
High Throughput ◽  
Transcriptome Profiling ◽  
Cell Types ◽  
Cell Transcriptome ◽  
Single Cell Transcriptome

scholarly journals Single cell transcriptome profiling of developing chick retinal cells

2017 ◽  
Vol 525 (12) ◽  
pp. 2735-2781 ◽  
Author(s):  
Lauren A. Laboissonniere ◽  
Gregory M. Martin ◽  
Jillian J. Goetz ◽  
Ran Bi ◽  
Brock Pope ◽  
...  
Keyword(s):  
Single Cell ◽  
Transcriptome Profiling ◽  
Retinal Cells ◽  
Cell Transcriptome ◽  
Single Cell Transcriptome

scholarly journals Single-cell transcriptome analysis demonstrates inter-patient and intra-tumor heterogeneity in primary and metastatic lung adenocarcinoma

Aging ◽  
2020 ◽  
Vol 12 (21) ◽  
pp. 21559-21581
Author(s):  
Yafei Liu ◽  
Guanchao Ye ◽  
Lan Huang ◽  
Chunyang Zhang ◽  
Yinliang Sheng ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Single Cell ◽  
Transcriptome Analysis ◽  
Tumor Heterogeneity ◽  
Metastatic Lung ◽  
Cell Transcriptome ◽  
Single Cell Transcriptome

scholarly journals Single-cell transcriptome analysis reveals cell lineage specification in temporal-spatial patterns in human cortical development

2020 ◽  
Vol 6 (34) ◽  
pp. eaaz2978 ◽  
Author(s):  
Xiaoying Fan ◽  
Yuanyuan Fu ◽  
Xin Zhou ◽  
Le Sun ◽  
Ming Yang ◽  
...  
Keyword(s):  
Single Cell ◽  
Neural Progenitor Cells ◽  
Neuronal Development ◽  
Single Cell Analysis ◽  
Cortical Development ◽  
Cell Lineage ◽  
Transcriptome Profiling ◽  
Developmental Trajectory ◽  
Cell Transcriptome ◽  
Single Cell Transcriptome

Neurogenesis processes differ in different areas of the cortex in many species, including humans. Here, we performed single-cell transcriptome profiling of the four cortical lobes and pons during human embryonic and fetal development. We identified distinct subtypes of neural progenitor cells (NPCs) and their molecular signatures, including a group of previously unidentified transient NPCs. We specified the neurogenesis path and molecular regulations of the human deep-layer, upper-layer, and mature neurons. Neurons showed clear spatial and temporal distinctions, while glial cells of different origins showed development patterns similar to those of mice, and we captured the developmental trajectory of oligodendrocyte lineage cells until the human mid-fetal stage. Additionally, we verified region-specific characteristics of neurons in the cortex, including their distinct electrophysiological features. With systematic single-cell analysis, we decoded human neuronal development in temporal and spatial dimensions from GW7 to GW28, offering deeper insights into the molecular regulations underlying human neurogenesis and cortical development.

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