scholarly journals Microfluidic Cell Trap Arrays for Single Hematopoietic Stem/Progenitor Cell Behavior Analysis

PROTEOMICS ◽  
2020 ◽  
Vol 20 (13) ◽  
pp. 1900223 ◽  
Author(s):  
Xin Han ◽  
Yuan Ma ◽  
Kai Zhang ◽  
Pengchao Zhang ◽  
Ning Shao ◽  
...  
Keyword(s):  
Behavior Analysis ◽  
Progenitor Cell ◽  
Cell Behavior ◽  
Hematopoietic Stem

scholarly journals A Single Metabolite which Modulates Lipid Metabolism Alters Hematopoietic Stem/Progenitor Cell Behavior and Promotes Lymphoid Reconstitution

2020 ◽  
Vol 15 (3) ◽  
pp. 566-576
Author(s):  
Sonja Giger ◽  
Larisa V. Kovtonyuk ◽  
Sebastian G. Utz ◽  
Mergim Ramosaj ◽  
Werner J. Kovacs ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Progenitor Cell ◽  
Cell Behavior ◽  
Hematopoietic Stem

scholarly journals Analyzing signaling activity and function in hematopoietic cells

2021 ◽  
Vol 218 (7) ◽  
Author(s):  
Tobias Kull ◽  
Timm Schroeder
Keyword(s):  
Cell Signaling ◽  
Signaling Pathways ◽  
Progenitor Cell ◽  
Cell Behavior ◽  
Cell Fates ◽  
Hematopoietic Stem ◽  
Related Individual ◽  
Health And Disease ◽  
And Function ◽  
Signaling Activity

Cells constantly sense their environment, allowing the adaption of cell behavior to changing needs. Fine-tuned responses to complex inputs are computed by signaling pathways, which are wired in complex connected networks. Their activity is highly context-dependent, dynamic, and heterogeneous even between closely related individual cells. Despite lots of progress, our understanding of the precise implementation, relevance, and possible manipulation of cellular signaling in health and disease therefore remains limited. Here, we discuss the requirements, potential, and limitations of the different current technologies for the analysis of hematopoietic stem and progenitor cell signaling and its effect on cell fates.

scholarly journals Emerging roles for motor proteins in progenitor cell behavior and neuronal migration during brain development

Cytoskeleton ◽  
2016 ◽  
Vol 73 (9) ◽  
pp. Spc1-Spc1
Author(s):  
Tiago J. Dantas ◽  
Aurelie Carabalona ◽  
Daniel Jun-Kit Hu ◽  
Richard B. Vallee
Keyword(s):  
Brain Development ◽  
Neuronal Migration ◽  
Progenitor Cell ◽  
Motor Proteins ◽  
Cell Behavior

scholarly journals Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance

Blood ◽  
2010 ◽  
Vol 116 (17) ◽  
pp. 3197-3207 ◽  
Author(s):  
Kirsteen J. Campbell ◽  
Mary L. Bath ◽  
Marian L. Turner ◽  
Cassandra J. Vandenberg ◽  
Philippe Bouillet ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Progenitor Cell ◽  
Fetal Liver ◽  
Cytotoxic Agents ◽  
Hematopoietic Stem ◽  
Stem And Progenitor Cells ◽  
Fetal Liver Cells ◽  
Follicular Lymphomas ◽  
The Impact

Abstract Diverse human cancers with poor prognosis, including many lymphoid and myeloid malignancies, exhibit high levels of Mcl-1. To explore the impact of Mcl-1 overexpression on the hematopoietic compartment, we have generated vavP-Mcl-1 transgenic mice. Their lymphoid and myeloid cells displayed increased resistance to a variety of cytotoxic agents. Myelopoiesis was relatively normal, but lymphopoiesis was clearly perturbed, with excess mature B and T cells accumulating. Rather than the follicular lymphomas typical of vavP-BCL-2 mice, aging vavP-Mcl-1 mice were primarily susceptible to lymphomas having the phenotype of a stem/progenitor cell (11 of 30 tumors) or pre-B cell (12 of 30 tumors). Mcl-1 overexpression dramatically accelerated Myc-driven lymphomagenesis. Most vavP-Mcl-1/ Eμ-Myc mice died around birth, and transplantation of blood from bitransgenic E18 embryos into unirradiated mice resulted in stem/progenitor cell tumors. Furthermore, lethally irradiated mice transplanted with E13 fetal liver cells from Mcl-1/Myc bitransgenic mice uniformly died of stem/progenitor cell tumors. When treated in vivo with cyclophosphamide, tumors coexpressing Mcl-1 and Myc transgenes were significantly more resistant than conventional Eμ-Myc lymphomas. Collectively, these results demonstrate that Mcl-1 overexpression renders hematopoietic cells refractory to many cytotoxic insults, perturbs lymphopoiesis and promotes malignant transformation of hematopoietic stem and progenitor cells.

scholarly journals Sequential regulation of hemogenic fate and hematopoietic stem and progenitor cell formation from arterial endothelium by Ezh1/2

2021 ◽  
Author(s):  
Rebecca A. Soto ◽  
Mohamad Ali T. Najia ◽  
Mariam Hachimi ◽  
Jenna M. Frame ◽  
Gabriel A. Yette ◽  
...  
Keyword(s):  
Progenitor Cell ◽  
Cell Formation ◽  
Hematopoietic Stem ◽  
Arterial Endothelium

scholarly journals 550. Primary Human CD34+ Hematopoietic Stem/Progenitor Cell (HSPC) Transduction By AAV6 Serotype Vectors: Strategies for Overcoming the Donor-Variation

2015 ◽  
Vol 23 ◽  
pp. S220-S221
Author(s):  
Zifei Yin ◽  
George V. Aslanidi ◽  
Chen Ling ◽  
Yuanhui Zhang ◽  
Changquan Ling ◽  
...  
Keyword(s):  
Progenitor Cell ◽  
Hematopoietic Stem ◽  
Human Cd34 ◽  
Donor Variation

scholarly journals Cutting Edge: Bacterial Infection Induces Hematopoietic Stem and Progenitor Cell Expansion in the Absence of TLR Signaling

2010 ◽  
Vol 184 (5) ◽  
pp. 2247-2251 ◽  
Author(s):  
Philip O. Scumpia ◽  
Kindra M. Kelly-Scumpia ◽  
Matthew J. Delano ◽  
Jason S. Weinstein ◽  
Alex G. Cuenca ◽  
...  
Keyword(s):  
Bacterial Infection ◽  
Cell Expansion ◽  
Progenitor Cell ◽  
Cutting Edge ◽  
Tlr Signaling ◽  
Hematopoietic Stem
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