Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2

PROTEOMICS ◽  
2019 ◽  
Vol 19 (24) ◽  
pp. 1900139 ◽  
Author(s):  
Aaron Botham ◽  
Etienne Coyaud ◽  
Victor Sanjit Nirmalanandhan ◽  
Marcela Gronda ◽  
Rose Hurren ◽  
...  
Keyword(s):  
Intermembrane Space ◽  
Mitochondrial Intermembrane Space ◽  
Interactome Mapping

scholarly journals Proteomic Mapping of the Human Mitochondrial Intermembrane Space in Live Cells via Ratiometric APEX Tagging

2014 ◽  
Vol 55 (2) ◽  
pp. 332-341 ◽  
Author(s):  
Victoria Hung ◽  
Peng Zou ◽  
Hyun-Woo Rhee ◽  
Namrata D. Udeshi ◽  
Valentin Cracan ◽  
...  
Keyword(s):  
Live Cells ◽  
Intermembrane Space ◽  
Mitochondrial Intermembrane Space

scholarly journals The Mitochondrial Intermembrane Space Oxireductase Mia40 Funnels the Oxidative Folding Pathway of the CytochromecOxidase Assembly Protein Cox19

2014 ◽  
Vol 289 (14) ◽  
pp. 9852-9864 ◽  
Author(s):  
Hugo Fraga ◽  
Joan-Josep Bech-Serra ◽  
Francesc Canals ◽  
Gabriel Ortega ◽  
Oscar Millet ◽  
...  
Keyword(s):  
Folding Pathway ◽  
Intermembrane Space ◽  
Oxidative Folding ◽  
Mitochondrial Intermembrane Space

The Yeast Mitochondrial Intermembrane Space: Purification and Analysis of Two Distinct Fractions

1998 ◽  
Vol 265 (1) ◽  
pp. 123-128 ◽  
Author(s):  
Heiko Martin ◽  
Christoph Eckerskorn ◽  
Frank Gärtner ◽  
Joachim Rassow ◽  
Fritz Lottspeich ◽  
...  
Keyword(s):  
Intermembrane Space ◽  
Mitochondrial Intermembrane Space

Computational studies of the mitochondrial carrier family SLC25. Present status and future perspectives

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Andrea Pasquadibisceglie ◽  
Fabio Polticelli
Keyword(s):  
Transport Mechanism ◽  
Experimental Studies ◽  
Intermembrane Space ◽  
Mitochondrial Carrier ◽  
Mitochondrial Homeostasis ◽  
The Matrix ◽  
Mitochondrial Carrier Family ◽  
Mitochondrial Intermembrane Space ◽  
Computational Analyses

Abstract The members of the mitochondrial carrier family, also known as solute carrier family 25 (SLC25), are transmembrane proteins involved in the translocation of a plethora of small molecules between the mitochondrial intermembrane space and the matrix. These transporters are characterized by three homologous domains structure and a transport mechanism that involves the transition between different conformations. Mutations in regions critical for these transporters’ function often cause several diseases, given the crucial role of these proteins in the mitochondrial homeostasis. Experimental studies can be problematic in the case of membrane proteins, in particular concerning the characterization of the structure–function relationships. For this reason, computational methods are often applied in order to develop new hypotheses or to support/explain experimental evidence. Here the computational analyses carried out on the SLC25 members are reviewed, describing the main techniques used and the outcome in terms of improved knowledge of the transport mechanism. Potential future applications on this protein family of more recent and advanced in silico methods are also suggested.

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