Plectin is Required for Trans-Endothelial Permeability: A Model of Plectin Dysfunction in Human Endothelial Cells After TNF-α Treatment and Dengue Virus Infection

PROTEOMICS ◽  
2018 ◽  
Vol 18 (23) ◽  
pp. 1800215 ◽  
Author(s):  
Aroonroong Suttitheptumrong ◽  
Nantapon Rawarak ◽  
Onrapak Reamtong ◽  
Kobporn Boonnak ◽  
Sa-nga Pattanakitsakul
Keyword(s):  
Endothelial Cells ◽  
Virus Infection ◽  
Dengue Virus ◽  
Endothelial Permeability ◽  
Human Endothelial Cells ◽  
Dengue Virus Infection ◽  
Tnf Α

scholarly journals The Ubiquitin−Proteasome Pathway Is Important for Dengue Virus Infection in Primary Human Endothelial Cells

2010 ◽  
Vol 9 (10) ◽  
pp. 4960-4971 ◽  
Author(s):  
Rattiyaporn Kanlaya ◽  
Sa-nga Pattanakitsakul ◽  
Supachok Sinchaikul ◽  
Shui-Tein Chen ◽  
Visith Thongboonkerd
Keyword(s):  
Endothelial Cells ◽  
Virus Infection ◽  
Dengue Virus ◽  
Human Endothelial Cells ◽  
Dengue Virus Infection ◽  
Ubiquitin Proteasome Pathway ◽  
Ubiquitin Proteasome ◽  
Proteasome Pathway

Tissue plasminogen activator induced by dengue virus infection of human endothelial cells

2003 ◽  
Vol 70 (4) ◽  
pp. 610-616 ◽  
Author(s):  
Ying-Huey Huang ◽  
Huan-Yao Lei ◽  
Hsiao-Sheng Liu ◽  
Yee-Shin Lin ◽  
Shun-Hua Chen ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Virus Infection ◽  
Dengue Virus ◽  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Human Endothelial Cells ◽  
Dengue Virus Infection ◽  
Tissue Plasminogen

scholarly journals Association of Alix with Late Endosomal Lysobisphosphatidic Acid Is Important for Dengue Virus Infection in Human Endothelial Cells

2010 ◽  
Vol 9 (9) ◽  
pp. 4640-4648 ◽  
Author(s):  
Sa-nga Pattanakitsakul ◽  
Jesdaporn Poungsawai ◽  
Rattiyaporn Kanlaya ◽  
Supachok Sinchaikul ◽  
Shui-Tein Chen ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Virus Infection ◽  
Dengue Virus ◽  
Human Endothelial Cells ◽  
Dengue Virus Infection ◽  
Lysobisphosphatidic Acid

scholarly journals Suppressive Effects of the Gynura bicolor Ether Extract on Endothelial Permeability and Leukocyte Transmigration in Human Endothelial Cells Induced by TNF-α

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Shu-Ling Hsieh ◽  
Jyh-Jye Wang ◽  
Kuan-Hua Su ◽  
Ying-Lan Kuo ◽  
Shuchen Hsieh ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Adhesion Molecule ◽  
Far East ◽  
Endothelial Permeability ◽  
Intercellular Adhesion Molecule ◽  
Ether Extract ◽  
Human Endothelial Cells ◽  
Tnf Α ◽  
Ea.Hy926 Cells ◽  
Gynura Bicolor

Gynura bicolor (Roxb. and Willd.) DC (G. bicolor) is generally used as a dietary vegetable and traditional herb in Taiwan and the Far East. G. bicolor exerts antioxidant and anti-inflammatory effects and regulates blood lipids and cholesterol. However, the effects of G. bicolor on endothelial transmigration and atherosclerosis are not clear. The present study investigated the effects of G. bicolor on endothelial permeability and transmigration in human endothelial cells. We prepared G. bicolor ether extract (GBEE) for use as the experimental material. Under TNF-α stimulation, HL-60 cell adherence to EA.hy926 cells, the shape of EA.hy926 cells, and the expression of adhesion molecules and transmigration-related regulatory molecules were analysed after pretreatment with GBEE for 24 h. GBEE inhibited leukocyte adhesion to endothelial cells, reduced intercellular adhesion molecule-1 (ICAM-1) and platelet endothelial cell adhesion molecule-1 (PECAM-1) expressions, and decreased endothelial monolayer permeability. GBEE also reduced paracellular transmigration by reducing the levels of reactive oxygen species (ROS), Src phosphorylation, and vascular endothelial-cadherin (VE-cadherin) phosphorylation. GBEE reduced transcellular migration via inhibition of Ras homolog family member A (RhoA) and Rho-associated protein kinase (ROCK) expression and phosphorylation of the ezrin-radixin-moesin (ERM) protein. Incubation of EA.hy926 cells with GBEE for 8 h and stimulation with TNF-α for 3 h reduced the phosphorylation of the inhibitor of kappa B (IĸB) and DNA-binding activity of nuclear factor-ĸB (NF-ĸB). These results suggest that GBEE has a protective effect against endothelial dysfunction via suppression of leukocyte-endothelium adhesion and transmigration.

scholarly journals Senescence Affects Endothelial Cells Susceptibility to Dengue Virus Infection

2014 ◽  
Vol 11 (6) ◽  
pp. 538-544 ◽  
Author(s):  
Sazaly AbuBakar ◽  
Meng-Hooi Shu ◽  
Jefree Johari ◽  
Pooi-Fong Wong
Keyword(s):  
Endothelial Cells ◽  
Virus Infection ◽  
Dengue Virus ◽  
Dengue Virus Infection

scholarly journals Dengue Virus Infection Mediates HMGB1 Release from Monocytes Involving PCAF Acetylase Complex and Induces Vascular Leakage in Endothelial Cells

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e41932 ◽  
Author(s):  
Siew Pei Ong ◽  
Ling Min Lee ◽  
Yew Fai Ivan Leong ◽  
Mah Lee Ng ◽  
Justin Jang Hann Chu
Keyword(s):  
Endothelial Cells ◽  
Virus Infection ◽  
Dengue Virus ◽  
Vascular Leakage ◽  
Dengue Virus Infection
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