scholarly journals Phosphoproteomics Profiling of Nonsmall Cell Lung Cancer Cells Treated with a Novel Phosphatase Activator

PROTEOMICS ◽  
2017 ◽  
Vol 17 (22) ◽  
pp. 1700214 ◽  
Author(s):  
Danica D. Wiredja ◽  
Marzieh Ayati ◽  
Sahar Mazhar ◽  
Jaya Sangodkar ◽  
Sean Maxwell ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Nonsmall Cell Lung Cancer ◽  
Lung Cancer Cells

scholarly journals Chloroquine Enhances Gefitinib Cytotoxicity in Gefitinib-Resistant Nonsmall Cell Lung Cancer Cells

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0119135 ◽  
Author(s):  
Mei-Chuan Tang ◽  
Mei-Yi Wu ◽  
Ming-Hung Hwang ◽  
Ya-Ting Chang ◽  
Hui-Ju Huang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Nonsmall Cell Lung Cancer ◽  
Lung Cancer Cells

scholarly journals Pemetrexed downregulates ERCC1 expression and enhances cytotoxicity effected by resveratrol in human nonsmall cell lung cancer cells

2013 ◽  
Vol 386 (12) ◽  
pp. 1047-1059 ◽  
Author(s):  
Ruey-Shyang Chen ◽  
Jen-Chung Ko ◽  
Hsien-Chun Chiu ◽  
Ting-Yu Wo ◽  
Yi-Jhen Huang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Nonsmall Cell Lung Cancer ◽  
Lung Cancer Cells ◽  
Ercc1 Expression

scholarly journals Long Noncoding RNA PTPRG Antisense RNA 1 Reduces Radiosensitivity of Nonsmall Cell Lung Cancer Cells Via Regulating MiR-200c-3p/TCF4

2020 ◽  
Vol 19 ◽  
pp. 153303382094261
Author(s):  
Qiang Ma ◽  
Rungui Niu ◽  
Wei Huang ◽  
Liangshan Da ◽  
Yanlei Tang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Transcription Factor ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Antisense Rna ◽  
Nonsmall Cell Lung Cancer ◽  
Lung Cancer Cells ◽  
X Ray ◽  
Transcription Factor 4 ◽  
Cancer Tissues

Background: PTPRG antisense RNA 1 has been well-documented to exert an oncogenic role in diverse neoplasms. However, the precise role of PTPRG antisense RNA 1 in regulating radiosensitivity of nonsmall cell lung cancer cells remains largely elusive. Methods: Expression levels of PTPRG antisense RNA 1 and miR-200c-3p in nonsmall cell lung cancer tissues and cells were detected by quantitative real-time polymerase chain reaction, while transcription factor 4 expression was examined by immunohistochemistry and Western blot. After nonsmall cell lung cancer cells were exposed to X-ray with different doses in vitro, Cell Counting Kit -8 assay and colony formation assay were conducted to determine the influence of PTPRG antisense RNA 1 on cell viability. Interaction between miR-200c-3p and PTPRG antisense RNA 1 as well as transcription factor 4 was investigated by dual luciferase reporter assay. Result: In nonsmall cell lung cancer tissues, the expressions of PTPRG antisense RNA 1 and transcription factor 4 were significantly upregulated, whereas the expression of miR-200c-3p was downregulated. It was also proved that PTPRG antisense RNA 1 and 3′-untranslated region of transcription factor 4 can bind to miR-200c-3p. Under X-ray irradiation, overexpressed PTPRG antisense RNA 1 could promote the viability and enhance the radioresistance of nonsmall cell lung cancer cells, and this effect was partially weakened by miR-200c-3p mimics. Transcription factor 4 was identified as a target gene of miR-200c-3p, which could be positively regulated by PTPRG antisense RNA 1. Conclusion: PTPRG antisense RNA 1 reduces the radiosensitivity of nonsmall cell lung cancer cells via modulating miR-200c-3p/TCF4 axis.

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