Comprehensive proteomic analysis of a Chinese 2-herb formula (Astragali Radix and Rehmanniae Radix) on mature endothelial cells

PROTEOMICS ◽  
2014 ◽  
Vol 14 (17-18) ◽  
pp. 2089-2103 ◽  
Author(s):  
Jacqueline Chor Wing Tam ◽  
Chun Hay Ko ◽  
Cheng Zhang ◽  
Hua Wang ◽  
Ching Po Lau ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Proteomic Analysis ◽  
Astragali Radix ◽  
Rehmanniae Radix

Proteomic Analysis of Lipid Microdomains from Lipopolysaccharide-Activated Human Endothelial Cells

2005 ◽  
Vol 4 (2) ◽  
pp. 349-357 ◽  
Author(s):  
Aly Karsan ◽  
Josip Blonder ◽  
Jennifer Law ◽  
Elisa Yaquian ◽  
David A. Lucas ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Proteomic Analysis ◽  
Human Endothelial Cells ◽  
Lipid Microdomains

scholarly journals Impact of Spaceflight and Artificial Gravity on the Mouse Retina: Biochemical and Proteomic Analysis

2018 ◽  
Vol 19 (9) ◽  
pp. 2546 ◽  
Author(s):  
Xiao Mao ◽  
Stephanie Byrum ◽  
Nina Nishiyama ◽  
Michael Pecaut ◽  
Vijayalakshmi Sridharan ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Visual Acuity ◽  
Protein Expression ◽  
Proteomic Analysis ◽  
Vascular Endothelial Cells ◽  
Expression Profiles ◽  
Artificial Gravity ◽  
Ocular Tissue ◽  
Mouse Retina ◽  
Vascular Endothelial

Astronauts are reported to have experienced some impairment in visual acuity during their mission on the International Space Station (ISS) and after they returned to Earth. There is emerging evidence that changes in vision may involve alterations in ocular structure and function. To investigate possible mechanisms, changes in protein expression profiles and oxidative stress-associated apoptosis were examined in mouse ocular tissue after spaceflight. Nine-week-old male C57BL/6 mice (n = 12) were launched from the Kennedy Space Center on a SpaceX rocket to the ISS for a 35-day mission. The animals were housed in the mouse Habitat Cage Unit (HCU) in the Japan Aerospace Exploration Agency (JAXA) “Kibo” facility on the ISS. The flight mice lived either under an ambient microgravity condition (µg) or in a centrifugal habitat unit that produced 1 g artificial gravity (µg + 1 g). Habitat control (HC) and vivarium control mice lived on Earth in HCUs or normal vivarium cages, respectively. Quantitative assessment of ocular tissue demonstrated that the µg group induced significant apoptosis in the retina vascular endothelial cells compared to all other groups (p < 0.05) that was 64% greater than that in the HC group. Proteomic analysis showed that many key pathways responsible for cell death, cell repair, inflammation, and metabolic stress were significantly altered in µg mice compared to HC animals. Additionally, there were more significant changes in regulated protein expression in the µg group relative to that in the µg + 1 g group. These data provide evidence that spaceflight induces retinal apoptosis of vascular endothelial cells and changes in retinal protein expression related to cellular structure, immune response and metabolic function, and that artificial gravity (AG) provides some protection against these changes. These retinal cellular responses may affect blood–retinal barrier (BRB) integrity, visual acuity, and impact the potential risk of developing late retinal degeneration.

Proteomic analysis of the proteins expressed by hydrogen peroxide treated cultured human dermal microvascular endothelial cells

PROTEOMICS ◽  
2005 ◽  
Vol 5 (6) ◽  
pp. 1507-1519 ◽  
Author(s):  
Moon Kyung Ha ◽  
Kee Yang Chung ◽  
Dongsik Bang ◽  
Yoon Kee Park ◽  
Kwang Hoon Lee
Keyword(s):  
Hydrogen Peroxide ◽  
Endothelial Cells ◽  
Proteomic Analysis ◽  
Microvascular Endothelial Cells ◽  
Microvascular Endothelial

Proteomic Analysis of Human Cerebral Endothelial Cells Activated by Glutamate/MK-801: Significance in Ischemic Stroke Injury

2008 ◽  
Vol 38 (2) ◽  
pp. 182-192 ◽  
Author(s):  
Alireza Minagar ◽  
J. Steven Alexander ◽  
Roger E. Kelley ◽  
Michael Harper ◽  
Merilyn H. Jennings
Keyword(s):  
Endothelial Cells ◽  
Ischemic Stroke ◽  
Proteomic Analysis ◽  
Mk 801 ◽  
Cerebral Endothelial Cells

Proteomic analysis of human umbilical vein endothelial cells incubated with Cryptococcus neoformans var. neoformans

Mycoses ◽  
2010 ◽  
Vol 54 (5) ◽  
pp. e336-e343 ◽  
Author(s):  
Xiao-Jun Wang ◽  
Yuan-Jie Zhu ◽  
Jian-Guo Cui ◽  
Xin Huang ◽  
Julin Gu ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cryptococcus Neoformans ◽  
Proteomic Analysis ◽  
Umbilical Vein ◽  
Human Umbilical Vein ◽  
Umbilical Vein Endothelial Cells

Proteomic Analysis of Human Cerebral Endothelial Cells Activated by Multiple Sclerosis Serum and IFNβ-1b

2007 ◽  
Vol 32 (3) ◽  
pp. 169-178 ◽  
Author(s):  
J. Steven Alexander ◽  
Alireza Minagar ◽  
Michael Harper ◽  
Sherry Robinson-Jackson ◽  
Merilyn Jennings ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Endothelial Cells ◽  
Proteomic Analysis ◽  
Cerebral Endothelial Cells
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