scholarly journals MALDI imaging mass spectrometry profiling of proteins and lipids in clear cell renal cell carcinoma

PROTEOMICS ◽  
2014 ◽  
Vol 14 (7-8) ◽  
pp. 924-935 ◽  
Author(s):  
Elizabeth Ellen Jones ◽  
Thomas W. Powers ◽  
Benjamin A. Neely ◽  
Lisa H. Cazares ◽  
Dean A. Troyer ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Imaging Mass Spectrometry ◽  
Maldi Imaging ◽  
Cell Renal Cell Carcinoma ◽  
Maldi Imaging Mass Spectrometry

scholarly journals Imaging Mass Spectrometry Is an Accurate Tool in Differentiating Clear Cell Renal Cell Carcinoma and Chromophobe Renal Cell Carcinoma: A Proof-of-concept Study

2020 ◽  
Vol 68 (6) ◽  
pp. 403-411
Author(s):  
Hsiang-Chih Lu ◽  
Nathan Heath Patterson ◽  
Audra M. Judd ◽  
Michelle L. Reyzer ◽  
Jennifer K. Sehn
Keyword(s):  
Mass Spectrometry ◽  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Imaging Mass Spectrometry ◽  
Chromophobe Renal Cell Carcinoma ◽  
Classification Model ◽  
High Grade ◽  
Cell Renal Cell Carcinoma

Clear cell renal cell carcinoma (ccRCC) and chromophobe renal cell carcinoma (chRCC) are relatively common tumors that can have significant risk for mortality. Treatment and prognostication in renal cell carcinoma (RCC) are dependent upon correct histologic typing. ccRCC and chRCC are generally straightforward to diagnose based on histomorphology alone. However, high-grade ccRCC and chRCC can sometimes resemble each other morphologically, particularly in small biopsies. Multiple immunostains and/or colloidal iron stain are sometimes required to differentiate the two. Imaging mass spectrometry (IMS) allows simultaneous spatial mapping of thousands of biomarkers, using formalin-fixed paraffin-embedded tissue sections. In this study, we evaluate the ability of IMS to differentiate between World Health Organization/International Society for Urological Pathology grade 3 ccRCC and chRCC. IMS spectra from a training set of 14 ccRCC and 13 chRCC were evaluated via support vector machine algorithm with a linear kernel for machine learning, building a classification model. The classification model was applied to a separate validation set of 6 ccRCC and 6 chRCC, with 19 to 20, 150-μm diameter tumor foci in each case sampled by IMS. Most evaluated tumor foci were classified correctly as ccRCC versus chRCC (99% accuracy, kappa=0.98), demonstrating that IMS is an accurate tool in differentiating high-grade ccRCC and chRCC.

scholarly journals Coupled Mass-Spectrometry-Based Lipidomics Machine Learning Approach for Early Detection of Clear Cell Renal Cell Carcinoma

2020 ◽  
Vol 20 (1) ◽  
pp. 841-857
Author(s):  
Malena Manzi ◽  
Martín Palazzo ◽  
María Elena Knott ◽  
Pierre Beauseroy ◽  
Patricio Yankilevich ◽  
...  
Keyword(s):  
Machine Learning ◽  
Mass Spectrometry ◽  
Renal Cell Carcinoma ◽  
Early Detection ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Learning Approach ◽  
Cell Renal Cell Carcinoma ◽  
Machine Learning Approach

scholarly journals Identification of diagnostic metabolic signatures in clear cell renal cell carcinoma using mass spectrometry imaging

2020 ◽  
Vol 147 (1) ◽  
pp. 256-265 ◽  
Author(s):  
Kanchustambham Vijayalakshmi ◽  
Vishnu Shankar ◽  
Ryan M. Bain ◽  
Rosalie Nolley ◽  
Geoffrey A. Sonn ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Mass Spectrometry Imaging ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Metabolic Signatures

scholarly journals A Mass Spectrometry-based Lipidomics Study for Early Diagnosis of clear cell Renal Cell Carcinoma

2018 ◽  
Author(s):  
Malena Manzi ◽  
Martín Palazzo ◽  
Nicolás Zabalegui ◽  
María Knott ◽  
Patricio Yankilevich ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Renal Cell Carcinoma ◽  
Early Diagnosis ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma

638: Macroscopic Tumor Necrosis is a Prognostic Indicator for Non-Metastatic Clear Cell Renal Cell Carcinoma

2007 ◽  
Vol 177 (4S) ◽  
pp. 214-214
Author(s):  
Sung Kyu Hong ◽  
Byung Kyu Han ◽  
In Ho Chang ◽  
June Hyun Han ◽  
Ji Hyung Yu ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Tumor Necrosis ◽  
Clear Cell ◽  
Prognostic Indicator ◽  
Cell Renal Cell Carcinoma ◽  
Macroscopic Tumor

Rare localization of renal cell carcinoma metastases in the paranasal sinuses and breast: a case report

2019 ◽  
Vol 22 (6) ◽  
pp. 13-22
Author(s):  
E. V. Kryaneva ◽  
N. A. Rubtsova ◽  
A. V. Levshakova ◽  
A. I. Khalimon ◽  
A. V. Leontyev ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Paranasal Sinuses ◽  
Renal Cell ◽  
Clinical Case ◽  
Clear Cell ◽  
Malignant Tumors ◽  
Metastatic Potential ◽  
Cell Renal Cell Carcinoma ◽  
Metastatic Lesions

This article presents a clinical case demonsratinga high metastatic potential of clear cell renal cell carcinoma combined with atypical metastases to breast and paranasal sinuses. The prevalence of metastatic lesions to the breast and paranasal sinuses in various malignant tumors depending on their morphological forms is analyzed. The authors present an analysis of data published for the last 30 years. The optimal diagnostic algorithms to detect the progression of renal cell carcinoma and to evaluate the effectiveness of the treatment are considered.

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