scholarly journals Sporadic C reutzfeldt– J akob disease subtype‐specific alterations of the brain proteome: Impact on R ab3a recycling

PROTEOMICS ◽  
2012 ◽  
Vol 12 (23-24) ◽  
pp. 3610-3620 ◽  
Author(s):  
Joanna Gawinecka ◽  
Franco Cardone ◽  
Abdul R. Asif ◽  
Angela De Pascalis ◽  
Wiebke M. Wemheuer ◽  
...  
Keyword(s):  
Disease Subtype ◽  
Brain Proteome ◽  
The Brain

scholarly journals Network analysis of the brain proteome of GRN knockout mice reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations

2020 ◽  
Vol 16 (S3) ◽  
Author(s):  
Thomas Kukar ◽  
Meixiang Huang ◽  
Erica S Modeste ◽  
Eric B Dammer ◽  
Christopher J Holler ◽  
...  
Keyword(s):  
Network Analysis ◽  
Frontotemporal Dementia ◽  
Knockout Mice ◽  
Pathogenic Mechanisms ◽  
Brain Proteome ◽  
The Brain

scholarly journals Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer’s disease

2020 ◽  
Vol 6 (43) ◽  
pp. eaaz9360 ◽  
Author(s):  
Lenora Higginbotham ◽  
Lingyan Ping ◽  
Eric B. Dammer ◽  
Duc M. Duong ◽  
Maotian Zhou ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Wide Spectrum ◽  
Csf Biomarkers ◽  
Protein Biomarkers ◽  
Cerebrospinal Fluid Biomarkers ◽  
Brain Proteome ◽  
The Brain ◽  
Underlying Pathophysiology

Alzheimer’s disease (AD) lacks protein biomarkers reflective of its diverse underlying pathophysiology, hindering diagnostic and therapeutic advancements. Here, we used integrative proteomics to identify cerebrospinal fluid (CSF) biomarkers representing a wide spectrum of AD pathophysiology. Multiplex mass spectrometry identified ~3500 and ~12,000 proteins in AD CSF and brain, respectively. Network analysis of the brain proteome resolved 44 biologically diverse modules, 15 of which overlapped with the CSF proteome. CSF AD markers in these overlapping modules were collapsed into five protein panels representing distinct pathophysiological processes. Synaptic and metabolic panels were decreased in AD brain but increased in CSF, while glial-enriched myelination and immunity panels were increased in brain and CSF. The consistency and disease specificity of panel changes were confirmed in >500 additional CSF samples. These panels also identified biological subpopulations within asymptomatic AD. Overall, these results are a promising step toward a network-based biomarker tool for AD clinical applications.

Responses in the brain proteome of Atlantic cod (Gadus morhua) exposed to methylmercury

2010 ◽  
Vol 100 (1) ◽  
pp. 51-65 ◽  
Author(s):  
Karin Berg ◽  
Pål Puntervoll ◽  
Stig Valdersnes ◽  
Anders Goksøyr
Keyword(s):  
Gadus Morhua ◽  
Atlantic Cod ◽  
Brain Proteome ◽  
The Brain

scholarly journals Alzheimer and vascular brain disease: Senile dementia

2015 ◽  
Vol 9 (2) ◽  
pp. 184-188 ◽  
Author(s):  
Eliasz Engelhardt ◽  
Lea T. Grinberg
Keyword(s):  
Senile Dementia ◽  
Vascular Cognitive Impairment ◽  
Brain Disease ◽  
Brain Diseases ◽  
Heterogeneous Condition ◽  
Disease Subtype ◽  
Wide Range ◽  
Alois Alzheimer ◽  
Short Time ◽  
The Brain

Alois Alzheimer is best known for his description of a novel disease, subsequently named after him. However, his wide range of interests also included vascular brain diseases. He described Senile dementia, a highly heterogeneous condition, and was able not only to distinguish it from syphilitic brain disease, but also to discriminate two clinicopathological subtypes, that may be labeled a "arteriosclerotic subtype", comparable to the present clinicopathological continuum of "Vascular cognitive impairment", and another as a "neurodegenerative subtype", characterized by primary [cortical] ganglion cell [nerve cells] degeneration, possibly foreshadowing a peculiar presenile disease that he was to describe some years later and would carry his name. He also considered the possibility of a senile presentation of this disease subtype, which was described by Oskar Fischer a short time later. Considering the clinicopathological overlapping features of the "arteriosclerotic subtype" of Senile dementia with Arteriosclerotic atrophy of the brain, it might be possible to consider that both represent a single condition.

scholarly journals Proteomic Analysis of Hydromethylthionine in the Line 66 Model of Frontotemporal Dementia Demonstrates Actions on Tau-Dependent and Tau-Independent Networks

Cells ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 2162
Author(s):  
Karima Schwab ◽  
Valeria Melis ◽  
Charles R. Harrington ◽  
Claude M. Wischik ◽  
Mandy Magbagbeolu ◽  
...  
Keyword(s):  
Frontotemporal Dementia ◽  
Stress Responses ◽  
Protein Ubiquitination ◽  
Brain Proteome ◽  
Homeostatic Function ◽  
Behavioural Phenotypes ◽  
Tau Aggregation ◽  
The Brain ◽  
Key Pathways ◽  
Dimensional Electrophoresis

Abnormal aggregation of tau is the pathological hallmark of tauopathies including frontotemporal dementia (FTD). We have generated tau-transgenic mice that express the aggregation-prone P301S human tau (line 66). These mice present with early-onset, high tau load in brain and FTD-like behavioural deficiencies. Several of these behavioural phenotypes and tau pathology are reversed by treatment with hydromethylthionine but key pathways underlying these corrections remain elusive. In two proteomic experiments, line 66 mice were compared with wild-type mice and then vehicle and hydromethylthionine treatments of line 66 mice were compared. The brain proteome was investigated using two-dimensional electrophoresis and mass spectrometry to identify protein networks and pathways that were altered due to tau overexpression or modified by hydromethylthionine treatment. Overexpression of mutant tau induced metabolic/mitochondrial dysfunction, changes in synaptic transmission and in stress responses, and these functions were recovered by hydromethylthionine. Other pathways, such as NRF2, oxidative phosphorylation and protein ubiquitination were activated by hydromethylthionine, presumably independent of its function as a tau aggregation inhibitor. Our results suggest that hydromethylthionine recovers cellular activity in both a tau-dependent and a tau-independent fashion that could lead to a wide-spread improvement of homeostatic function in the FTD brain.

Neuroproteomics in Paving the Pathway for Drug Abuse Research

2019 ◽  
Vol 16 (4) ◽  
pp. 256-266
Author(s):  
Muhammad Naveed ◽  
Attha Tallat ◽  
Ayesha Butt ◽  
Maria Khalid ◽  
Marium Shehzadi ◽  
...  
Keyword(s):  
Drug Abuse ◽  
Drug Addiction ◽  
Complex Structure ◽  
Analytical Techniques ◽  
Cell Types ◽  
Brain Cells ◽  
Human Beings ◽  
Brain Proteome ◽  
The Brain ◽  
Brain Parts

Neuroproteomics, as a sub-discipline of proteomics, has enlightened the pathway for the study of different complicated diseases and brain disorders. Since four decades, various analytical and quantitative techniques have been used to cure problems related to brain and memory. Brain has a complex structure with various cells and cell types, the expressing proteins and suppressing factors too. Drug addiction is one of the main health concerns as it causes physiological changes in brain and affects its different parts. Some of these drugs like cocaine, marijuana, nicotine and alcohol not only affect memory and brain cells but also lead to expression and suppression of unwanted and beneficial proteins respectively. A variety of techniques involving separation techniques, quantification techniques and analytical techniques are used along with the combination of bioinformatics and magical tools for analyzing different aspects of brain parts especially proteome of the brain cells. Moreover, different animal models preferably those resembling human beings are routinely used in neuroproteomics to study the effects of different drugs on the brain proteome. Different experiments have already been performed by the researchers on drug abuse that helped massively in estimating not only the effects of drug addiction on the brain of highly complex organisms (human beings) but also to propose different therapeutics.

scholarly journals Proteomic Study of Hypothalamus in Pigs Exposed to Heat Stress

2019 ◽  
Author(s):  
Tianyue Yu ◽  
Yan-Hong Yong ◽  
Jun-yu Li ◽  
Biao Fang ◽  
Can-ying Hu ◽  
...  
Keyword(s):  
Heat Stress ◽  
Regulatory Networks ◽  
Protein Profile ◽  
Absolute Quantification ◽  
Farm Animals ◽  
Itraq Analysis ◽  
Canonical Pathways ◽  
Brain Proteome ◽  
Isobaric Tags ◽  
The Brain

Abstract Background: With evidence of warming climates, it is important to understand the effects of heat stress in farm animals in order to minimize production losses. Study of changes in the brain proteome induced by heat stress may aid in understanding how heat stress impacts brain function. The hypothalamus is a key region in the brain that controls the pituitary gland, which is responsible for the secretion of several important hormones. Result: In this study, we examined the hypothalamic protein profile of ten pigs (30–40 kg body weight), 5 of which were subjected to heat stress (35 ± 1°C; relative humidity = 90%) and 5 acting as controls (28 ± 3°C; RH = 90%). The isobaric tags for relative and absolute quantification (iTRAQ) analysis of the hypothalamus identified 1710 peptides corresponding to 360 proteins, and 295 deferentially expressed proteins (DEPs), 148 of which were up-regulated and 147 down-regulated in heat-stressed animals. Ingenuity Pathway Analysis software predicted 30 canonical pathways, 4 functional groups, and 4 regulatory networks of interest and the DEPs mainly concentrated in the cytoskeleton of the pig hypothalamus during heat stress. Conclusions: The upstream regulators of these 295 DEPs in the hypothalamus of the pig under HS are mainly transcriptional regulators, chemical drugs, and sRNA. This study provides reference data for further study of the mechanism of HS on hypothalamic physiology and metabolism(Illustration 1).

Irisin injection mimics exercise effects on the brain proteome

2021 ◽  
Author(s):  
Fariba Dehghan ◽  
Saeed Zamani ◽  
Carlos Barreiro ◽  
Mohammad‐Saeid Jami
Keyword(s):  
Brain Proteome ◽  
The Brain

MDC/CCL22 intrathecal levels in patients with multiple sclerosis

2008 ◽  
Vol 14 (4) ◽  
pp. 547-549 ◽  
Author(s):  
D. Galimberti ◽  
C. Fenoglio ◽  
C. Comi ◽  
D. Scalabrini ◽  
M. De Riz ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Experimental Autoimmune Encephalomyelitis ◽  
Th2 Cells ◽  
Autoimmune Encephalomyelitis ◽  
Disease Subtype ◽  
Male Patients ◽  
Fluid Levels ◽  
The Brain ◽  
Experimental Autoimmune

MDC/CCL22 has been detected in the brain of mice with experimental autoimmune encephalomyelitis. MDC/CCL22 cerebrospinal fluid levels were evaluated in 56 patients with multiple sclerosis (MS) and in 17 controls. No significant differences were found, even when stratifying patients according to the disease subtype. Stratifying by gender, significantly increased MDC/CCL22 levels were observed in female patients when compared with female controls and male patients (109.03 versus 98.54 and 99.37 pg/mL, P = 0.034 and 0.018, respectively). Therefore, MDC/CCL22 is likely to play a role in the development of MS in females only, possibly influencing the intracerebral recruitment of Th2 cells, which produce anti-inflammatory cytokines. Multiple Sclerosis 2008; 14: 547—549. http://msj.sagepub.com

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