Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy

PROTEOMICS ◽  
2011 ◽  
Vol 11 (12) ◽  
pp. 2459-2475 ◽  
Author(s):  
Pyong-Gon Moon ◽  
Jeong-Eun Lee ◽  
Sungyong You ◽  
Taek-Kyun Kim ◽  
Ji-Hoon Cho ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Iga Nephropathy ◽  
Proteomic Analysis ◽  
Thin Basement Membrane Nephropathy ◽  
Urinary Exosomes

Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy

2011 ◽  
Vol 5 (9-10) ◽  
pp. 568-568
Author(s):  
Pyong-Gon Moon ◽  
Jeong-Eun Lee ◽  
Sungyong You ◽  
Taek-Kyun Kim ◽  
Ji-Hoon Cho ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Iga Nephropathy ◽  
Proteomic Analysis ◽  
Thin Basement Membrane Nephropathy ◽  
Urinary Exosomes

A Novel Mutation of COL4A3 Presents a Different Contribution to Alport Syndrome and Thin Basement Membrane Nephropathy

2007 ◽  
Vol 27 (5) ◽  
pp. 538-544 ◽  
Author(s):  
Ping Hou ◽  
Yuqing Chen ◽  
Jiaxiang Ding ◽  
Guangtao Li ◽  
Hong Zhang
Keyword(s):  
Basement Membrane ◽  
Alport Syndrome ◽  
Novel Mutation ◽  
Thin Basement Membrane Nephropathy

scholarly journals Thin basement membrane disease – literature review

2015 ◽  
Vol 84 (3) ◽  
pp. 201-204
Author(s):  
Jakub Żurawski
Keyword(s):  
Electron Microscope ◽  
Basement Membrane ◽  
Literature Review ◽  
Iga Nephropathy ◽  
Glomerular Basement Membrane ◽  
Alport Syndrome ◽  
Clinical Course ◽  
Renal Diseases ◽  
Renal Lithiasis ◽  
Thin Basement Membrane Disease

Initially, the thin glomerular basement membrane disease was called “a gentle and curable hemorrhagic nephritis”. The thin basement membrane disease has been finally characterized at the beginning of 1970s. This is when the connection between previously clinically described gentle microhematuria and significant thinning of glomerular basement membrane discovered during examination under the electron-microscope has been established. Ultimately, the disease has been described as a condition characterized with a diverse clinical course, usually mild, but sometimes progressive. It is a family conditioned disease, but it also appears sporadically and concerns at least 1% of the population. It has also been stated that it is one of the most frequent renal diseases, enumerated directly after changes caused by infections, hypertension and renal lithiasis. This particular disease is diagnosed more often than IgA nephropathy and Alport syndrome, which are also associated with haematuria or microhematuria.

Incidence of Thin Basement Membrane Nephropathy in 990 Consecutive Renal Biopsies Examined with Electron Microscopy

2008 ◽  
Vol 32 (6) ◽  
pp. 221-226 ◽  
Author(s):  
Ioanna Zouvani ◽  
Sophia Aristodemou ◽  
Andreas Hadjisavvas ◽  
Thalia Michael ◽  
Mary Vassiliou ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Basement Membrane ◽  
Thin Basement Membrane Nephropathy ◽  
Renal Biopsies

Thin Basement Membrane Nephropathy

2009 ◽  
pp. 2045-2045
Author(s):  
Satish R. Raj ◽  
S. R. Wayne Chen ◽  
Robert S. Sheldon ◽  
Arti N. Shah ◽  
Bharat K. Kantharia ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Thin Basement Membrane Nephropathy

Comparative proteomic analysis of renal proteins from IgA nephropathy model mice and control mice

2020 ◽  
Vol 24 (8) ◽  
pp. 666-679
Author(s):  
Rena Miyakawa ◽  
Akiko Sato ◽  
Yuka Matsuda ◽  
Ayano Saito ◽  
Fumito Abe ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Proteomic Analysis ◽  
Comparative Proteomic Analysis ◽  
And Control

scholarly journals Prevalence of clinical, pathological and molecular features of glomerular basement membrane nephropathy caused by COL4A3 or COL4A4 mutations: a systematic review

2020 ◽  
Vol 13 (6) ◽  
pp. 1025-1036 ◽  
Author(s):  
Andreas Matthaiou ◽  
Tsielestina Poulli ◽  
Constantinos Deltas
Keyword(s):  
Basement Membrane ◽  
Alport Syndrome ◽  
Autosomal Dominant ◽  
Wide Spectrum ◽  
Age At Onset ◽  
Histological Finding ◽  
Basement Membranes ◽  
Thin Basement Membrane Nephropathy ◽  
Molecular Features ◽  
Thin Basement Membrane Disease

Abstract Background Patients heterozygous for COL4A3 or COL4A4 mutations show a wide spectrum of disease, extending from familial isolated microscopic haematuria, as a result of thin basement membranes (TBMs), to autosomal dominant Alport syndrome (ADAS) and end-stage renal disease (ESRD). Many patients are mentioned in the literature under the descriptive diagnosis of TBM nephropathy (TBMN), in which case it actually describes a histological finding that represents the carriers of autosomal recessive Alport syndrome (ARAS), a severe glomerulopathy, as most patients reach ESRD at a mean age of 25 years. Methods We performed a systematic literature review for patients with heterozygous COL4A3/A4 mutations with the aim of recording the spectrum and frequency of pathological features. We searched three databases (PubMed, Embase and Scopus) using the keywords ‘Autosomal Dominant Alport Syndrome’ OR ‘Thin Basement Membrane Disease’ OR ‘Thin Basement Membrane Nephropathy’. We identified 48 publications reporting on 777 patients from 258 families. Results In total, 29% of the patients developed chronic kidney disease (CKD) and 15.1% reached ESRD at a mean age of 52.8 years. Extrarenal features and typical Alport syndrome (AS) findings had a low prevalence in patients as follows: hearing loss, 16%; ocular lesions, 3%; basement membrane thickening, 18.4%; and podocyte foot process effacement, 6.9%. Data for 76 patients from 54 families emphasize extensive inter- and intrafamilial heterogeneity, with age at onset of ESRD ranging between 21 and 84 years (mean 52.8). Conclusions The analysis enabled a comparison of the clinical course of patients with typical ARAS or X-linked AS with those with heterozygous COL4A mutations diagnosed with TBMN or ADAS. Despite the consequence of a potential ascertainment bias, an important outcome is that TBM poses a global high risk of developing severe CKD, over a long follow-up, with a variable spectrum of other findings. The results are useful to practicing nephrologists for better evaluation of patients.

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