Honokiol inhibits HepG2 migration via down-regulation of IQGAP1 expression discovered by a quantitative pharmaceutical proteomic analysis

PROTEOMICS ◽  
2010 ◽  
Vol 10 (7) ◽  
pp. 1474-1483 ◽  
Author(s):  
Shufang Liang ◽  
Afu Fu ◽  
Qiang Zhang ◽  
Minghai Tang ◽  
Jin Zhou ◽  
...  
Keyword(s):  
Proteomic Analysis ◽  
Down Regulation

scholarly journals Down-Regulation of 14-3-3 Isoforms and Annexin A5 Proteins in Lung Adenocarcinoma Induced by the Tobacco-Specific Nitrosamine NNK in the A/J Mouse Revealed by Proteomic Analysis

2009 ◽  
Vol 8 (8) ◽  
pp. 4050-4061 ◽  
Author(s):  
James D. Bortner ◽  
Arunangshu Das ◽  
Todd M. Umstead ◽  
Williard M. Freeman ◽  
Richard Somiari ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Proteomic Analysis ◽  
Annexin A5 ◽  
Down Regulation

Proteomic analysis identifies prohibitin down-regulation as a crucial event in the mitochondrial damage observed in HIV-infected patients

2010 ◽  
Vol 15 (3) ◽  
pp. 377-390 ◽  
Author(s):  
Fabiola Ciccosanti ◽  
Marco Corazzari ◽  
Fabio Soldani ◽  
Paola Matarrese ◽  
Vittoria Pagliarini ◽  
...  
Keyword(s):  
Proteomic Analysis ◽  
Mitochondrial Damage ◽  
Down Regulation

Copper pretreatment augments ultraviolet B toxicity in the cyanobacterium Anabaena doliolum: a proteomic analysis of cell death

2008 ◽  
Vol 35 (5) ◽  
pp. 360 ◽  
Author(s):  
Poonam Bhargava ◽  
Arvind Kumar ◽  
Yogesh Mishra ◽  
Lal Chand Rai
Keyword(s):  
Superoxide Dismutase ◽  
Proteomic Analysis ◽  
Ultraviolet B ◽  
High Dose ◽  
Down Regulation ◽  
Two Dimensional Gel Electrophoresis ◽  
Anabaena Doliolum ◽  
Bisphosphate Carboxylase ◽  
Cyanobacterium Anabaena ◽  
Α Chain

This study provides first-hand proteomic characterisation of Cu-pretreatment-induced augmentation of ultraviolet B toxicity in the cyanobacterium Anabaena doliolum Bharadwaja. Of the three treatments (i.e. Cu, UV-B and Cu + UV-B) tested, the UV-B treatment of Cu-pretreated Anabaena produced a greater inhibition of oxygen evolution, 14C fixation, ATP and NADPH contents than UV-B alone. Proteomic analysis using two-dimensional gel electrophoresis (2DE), MALDI-TOF MS/MS and reverse transcription polymerase chain reaction (RT–PCR) of Cu, UV-B, and Cu + UV-B treated Anabaena exhibited significant and reproducible alterations in 12 proteins. Of these, manganese superoxide dismutase (Mn-SOD), iron superoxide dismutase (Fe-SOD) and peroxiredoxin (PER) are antioxidative enzymes; ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCo), phosphoribulokinase (PRK), flavodoxin (Flv), plastocyanin (PLC), phosphoglycerate kinase (PGK), phycocyanin (PC) and phycoerythrocyanin α-chain (PC α-chain) are linked with photosynthesis and respiration; and DnaK and nucleoside diphosphate kinase (NDPK) are associated with cellular processes and light signalling, respectively. However, when subjected to a high dose of UV-B, Cu-pretreated Anabaena depicted a severe down-regulation of DnaK, NDPK and Flv, probably because of inevitable oxidative stress. Thus, the augmentation of UV-B toxicity by Cu can be attributed to the down-regulation of DnaK, NDPK and Flv.

Proteomic analysis of pyridoxal oxime derivatives treated Listeria monocytogenes reveals down-regulation of the main virulence factor, Listeriolysin O

2020 ◽  
Vol 131 ◽  
pp. 108951 ◽  
Author(s):  
Martina Šrajer Gajdošik ◽  
Uroš Andjelković ◽  
Dajana Gašo-Sokač ◽  
Hrvoje Pavlović ◽  
Olga Shevchuk ◽  
...  
Keyword(s):  
Listeria Monocytogenes ◽  
Virulence Factor ◽  
Proteomic Analysis ◽  
Listeriolysin O ◽  
Down Regulation ◽  
Oxime Derivatives

scholarly journals Proteomic analysis of mouse brain cortex identifies metabolic down-regulation as a general feature of ischemic pre-conditioning

2012 ◽  
Vol 122 (6) ◽  
pp. 1219-1229 ◽  
Author(s):  
Giacomo Scornavacca ◽  
Raffaella Gesuete ◽  
Franca Orsini ◽  
Roberta Pastorelli ◽  
Roberto Fanelli ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Proteomic Analysis ◽  
General Feature ◽  
Brain Cortex ◽  
Down Regulation ◽  
Mouse Brain Cortex
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