Identification of novel and downregulated biomarkers for alcoholism by surface enhanced laser desorption/ionization-mass spectrometry

PROTEOMICS ◽  
2004 ◽  
Vol 4 (4) ◽  
pp. 1187-1194 ◽  
Author(s):  
Fumio Nomura ◽  
Takeshi Tomonaga ◽  
Kazuyuki Sogawa ◽  
Tatsuya Ohashi ◽  
Masahiko Nezu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Laser Desorption ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Desorption Ionization ◽  
Surface Enhanced

A spherical covalent-organic framework for enhancing laser desorption/ionization mass spectrometry for small molecule detection

The Analyst ◽  
2020 ◽  
Vol 145 (8) ◽  
pp. 3125-3130 ◽  
Author(s):  
Dan Ouyang ◽  
Kailong Luo ◽  
Wende Ma ◽  
Jie Wu ◽  
Jing Li ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Laser Desorption ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Covalent Organic Framework ◽  
Desorption Ionization ◽  
Surface Enhanced ◽  
Small Molecule Detection ◽  
Organic Framework

A spherical vinyl-functionalized covalent-organic framework (COF-V) was prepared at room temperature by a facile method and applied as a novel substrate for surface-enhanced laser desorption/ionization mass spectrometry (SELDI-MS).

scholarly journals Magnetic nanoparticle modified chitosan for surface enhanced laser desorption/ionization mass spectrometry of surfactants

RSC Advances ◽  
2017 ◽  
Vol 7 (66) ◽  
pp. 41585-41592 ◽  
Author(s):  
Hani Nasser Abdelhamid ◽  
Yu Chih Lin ◽  
Hui-Fen Wu
Keyword(s):  
Mass Spectrometry ◽  
Magnetic Nanoparticle ◽  
Laser Desorption ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Modified Chitosan ◽  
Desorption Ionization ◽  
Surface Enhanced ◽  
Modified Magnetic Nanoparticles

Chitosan (CTS) modified magnetic nanoparticles (CTS@Fe3O4MNPs) offer dual functions for the detection of surfactants using surface enhanced laser desorption/ionization mass spectrometry (SELDI-MS).

Surface-enhanced laser desorption/ionization mass spectrometry for rapid analysis of organic environmental pollutants by using polydopamine nanospheres as a substrate

The Analyst ◽  
2020 ◽  
Vol 145 (16) ◽  
pp. 5664-5669
Author(s):  
Kailong Luo ◽  
Baichuan Yang ◽  
Wenjing Guo ◽  
Qianqian Sun ◽  
Ouyang Dan ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Environmental Pollutants ◽  
Laser Desorption ◽  
Rapid Analysis ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Desorption Ionization ◽  
Surface Enhanced

Polydopamine nanospheres was designed to serve as a substrate for surface-enhanced desorption/ionization mass spectrometry, which showed superior LDI performance in the analysis of a variety of environmental pollutants.

scholarly journals Diagnosis of Agglomeration and Crystallinity of Active Pharmaceutical Ingredients in Over the Counter Headache Medication by Electrospray Laser Desorption Ionization Mass Spectrometry Imaging

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 610
Author(s):  
Mariann Inga Van Meter ◽  
Salah M. Khan ◽  
Brynne V. Taulbee-Cotton ◽  
Nathan H. Dimmitt ◽  
Nathan D. Hubbard ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometry Imaging ◽  
Laser Desorption ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Active Pharmaceutical Ingredients ◽  
Laser Desorption Ionization ◽  
Over The Counter ◽  
Pharmaceutical Ingredients ◽  
Desorption Ionization

Agglomeration of active pharmaceutical ingredients (API) in tablets can lead to decreased bioavailability in some enabling formulations. In a previous study, we determined that crystalline APIs can be detected as agglomeration in tablets formulated with amorphous acetaminophen tablets. Multiple method advancements are presented to better resolve agglomeration caused by crystallinity in standard tablets. In this study, we also evaluate three “budget” over-the-counter headache medications (subsequently labeled as brands A, B, and C) for agglomeration of the three APIs in the formulation: Acetaminophen, aspirin, and caffeine. Electrospray laser desorption ionization mass spectrometry imaging (ELDI-MSI) was used to diagnose agglomeration in the tablets by creating molecular images and observing the spatial distributions of the APIs. Brand A had virtually no agglomeration or clustering of the active ingredients. Brand B had extensive clustering of aspirin and caffeine, but acetaminophen was observed in near equal abundance across the tablet. Brand C also had extensive clustering of aspirin and caffeine, and minor clustering of acetaminophen. These results show that agglomeration with active ingredients in over-the-counter tablets can be simultaneously detected using ELDI-MS imaging.

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