scholarly journals The impact of personality disorders on treatment outcome in bipolar disorder: A review

2007 ◽  
Vol 1 (1) ◽  
pp. 2-13 ◽  
Author(s):  
Peter J. Bieling ◽  
Sheryl M. Green ◽  
Glenda Macqueen
2004 ◽  
Vol 34 (4) ◽  
pp. 659-669 ◽  
Author(s):  
J. M. CYRANOWSKI ◽  
E. FRANK ◽  
E. WINTER ◽  
P. RUCCI ◽  
D. NOVICK ◽  
...  

Background. Empirical data on the impact of personality pathology on acute treatment outcome for depression are mixed, in part because of challenges posed by assessing trait-like personality patterns while patients are in an active mood episode. To our knowledge, no previous study has examined the effect of personality pathology on maintenance treatment outcome. By maintenance treatment we refer to long-term treatment provided to prevent depression recurrence among remitted patients.Method. Structured Clinical Interviews for the DSM-III-R Personality Disorders (SCID-II) were obtained on a sample of 125 recurrently depressed women following sustained remission of the acute mood episode and prior to entering maintenance treatment. SCID-II interviews were then repeated following 1 and 2 years of maintenance interpersonal psychotherapy.Results. At the pre-maintenance assessment, 21·6% of the sample met SCID-II personality disorder criteria. Co-morbid personality pathology was related to an earlier age of onset, more previous depressive episodes, and a greater need for adjunctive pharmacotherapy to achieve remission of the acute mood episode. Co-morbid personality pathology predicted both higher rates of depression recurrence and a shorter time to recurrence over the 2-year course of maintenance treatment. Notably, among those patients who remained depression-free, continuous levels of personality pathology steadily declined over the 2-year course of maintenance therapy.Conclusions. Results highlight the need for early and effective intervention of both episodic mood disorder and inter-episode interpersonal dysfunction inherent to the personality disorders. Future maintenance treatment trials are needed to clarify the relationship between episodic mood disorder and personality function over time.


2010 ◽  
Vol 123 (1-3) ◽  
pp. 81-86 ◽  
Author(s):  
María Reinares ◽  
Francesc Colom ◽  
Adriane R. Rosa ◽  
C. Mar Bonnín ◽  
Carolina Franco ◽  
...  

2011 ◽  
Vol 26 (S2) ◽  
pp. 1710-1710
Author(s):  
D. Seretis ◽  
S. Nika ◽  
P. Nikolaidou ◽  
A. Papadopoulou ◽  
A. Douzenis ◽  
...  

IntroductionMedical comorbidity in patients with schizophrenia and bipolar disorder is associated with poor psychiatric treatment outcome and,for inpatients, with increased length of stay (LOS) -either by increasing psychiatric symptomatology or by being the focus of medical attention.ObjectivesTo assess the impact of medical comorbidity that receives medical attention (as opposed to lack of concurrent medical problems or to stable comorbidity) on clinical outcomes and LOS within two psychiatric populations.AimsTo estimate the prevalence of comorbid medical conditions in schizophrenia and bipolar disorder. To test for differences, primarily in LOS and psychiatric treatment outcome, between inpatients who received care for physical problems and those who did not need to.MethodsThis was a retrospective study of consecutive voluntary admissions of 106 patients suffering from schizophrenia and 110 patients suffering from bipolar disorder (type I or II). Our main independent variable was whether or not inpatients received treatment for a medical condition after referral from the attending psychiatrist. We used GAF and CIRS-SA assessments.ResultsMost reported problems for schizophrenia patients were cardiovascular/respiratory (notably hypertension) and for bipolar patients endocrine/metabolic. Patients who received medical treatment did not differ in LOS or psychiatric outcome from those who did not receive, in either diagnosis group. 84% of bipolar patients who reported a psychiatric comorbidity received treatment for a medical problem.ConclusionsMedical care for comorbid physical problems does not impact on LOS, diagnosis being a better predictor of the latter. In bipolar disorder significant medical burden appears to be drug-induced.


1997 ◽  
Vol 35 (10) ◽  
pp. 889-900 ◽  
Author(s):  
Carol J.M. Van Velzen ◽  
Paul M.G. Emmelkamp ◽  
Agnes Scholing

2019 ◽  
Vol 29 ◽  
pp. S1173-S1174
Author(s):  
James Crowley ◽  
Ashley Nordsletten ◽  
Gustaf Brander ◽  
Patrick Sullivan ◽  
Naomi Wray ◽  
...  

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