scholarly journals The regulation of ZCT1 , a transcriptional repressor of monoterpenoid indole alkaloid biosynthetic genes in Catharanthus roseus

Plant Direct ◽  
2019 ◽  
Vol 3 (12) ◽  
Author(s):  
Samuel Mortensen ◽  
Jessica D. Weaver ◽  
Suphinya Sathitloetsakun ◽  
Lauren F. Cole ◽  
Noreen F. Rizvi ◽  
...  
Keyword(s):  
Catharanthus Roseus ◽  
Transcriptional Repressor ◽  
Indole Alkaloid ◽  
Biosynthetic Genes ◽  
Monoterpenoid Indole Alkaloid

scholarly journals The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus

2015 ◽  
Vol 112 (26) ◽  
pp. 8130-8135 ◽  
Author(s):  
Alex Van Moerkercke ◽  
Priscille Steensma ◽  
Fabian Schweizer ◽  
Jacob Pollier ◽  
Ivo Gariboldi ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Catharanthus Roseus ◽  
Transcriptional Activation ◽  
Indole Alkaloid ◽  
Bioactive Metabolites ◽  
Bhlh Transcription Factor ◽  
Ethylene Response Factor ◽  
Madagascar Periwinkle ◽  
Genes Encoding ◽  
Monoterpenoid Indole Alkaloid

Plants make specialized bioactive metabolites to defend themselves against attackers. The conserved control mechanisms are based on transcriptional activation of the respective plant species-specific biosynthetic pathways by the phytohormone jasmonate. Knowledge of the transcription factors involved, particularly in terpenoid biosynthesis, remains fragmentary. By transcriptome analysis and functional screens in the medicinal plant Catharanthus roseus (Madagascar periwinkle), the unique source of the monoterpenoid indole alkaloid (MIA)-type anticancer drugs vincristine and vinblastine, we identified a jasmonate-regulated basic helix–loop–helix (bHLH) transcription factor from clade IVa inducing the monoterpenoid branch of the MIA pathway. The bHLH iridoid synthesis 1 (BIS1) transcription factor transactivated the expression of all of the genes encoding the enzymes that catalyze the sequential conversion of the ubiquitous terpenoid precursor geranyl diphosphate to the iridoid loganic acid. BIS1 acted in a complementary manner to the previously characterized ethylene response factor Octadecanoid derivative-Responsive Catharanthus APETALA2-domain 3 (ORCA3) that transactivates the expression of several genes encoding the enzymes catalyzing the conversion of loganic acid to the downstream MIAs. In contrast to ORCA3, overexpression of BIS1 was sufficient to boost production of high-value iridoids and MIAs in C. roseus suspension cell cultures. Hence, BIS1 might be a metabolic engineering tool to produce sustainably high-value MIAs in C. roseus plants or cultures.

scholarly journals Monoterpenoid Indole Alkaloids from Catharanthus roseus Cultivated in Yunnan

2015 ◽  
Vol 10 (12) ◽  
pp. 1934578X1501001
Author(s):  
Bei Wang ◽  
Lu Liu ◽  
Ying-Ying Chen ◽  
Qiong Li ◽  
Dan Li ◽  
...  
Keyword(s):  
Catharanthus Roseus ◽  
Spectroscopic Data ◽  
Spectroscopic Analysis ◽  
Indole Alkaloids ◽  
Indole Alkaloid ◽  
Monoterpenoid Indole Alkaloids ◽  
Monoterpenoid Indole Alkaloid ◽  
First Time

A new monoterpenoid indole alkaloid, 15,20-dehydro-3α-(2-oxopropyl) coronaridine (1), along with sixteen analogues (2–17) were isolated from the leaves of Catharanthus roseus cultivated in Yunnan. The new alkaloid was elucidated on the basis of extensive spectroscopic analysis, and the known alkaloids were identified by comparison with the reported spectroscopic data. Among them, alkaloid 16 was isolated from Catharanthus for the first time.

Fosmidomycin analogues as inhibitors of monoterpenoid indole alkaloid production in Catharanthus roseus cells

2005 ◽  
Vol 66 (15) ◽  
pp. 1797-1803 ◽  
Author(s):  
Zoia Mincheva ◽  
Martine Courtois ◽  
Françoise Andreu ◽  
Marc Rideau ◽  
Marie-Claude Viaud-Massuard
Keyword(s):  
Catharanthus Roseus ◽  
Indole Alkaloid ◽  
Alkaloid Production ◽  
Monoterpenoid Indole Alkaloid

ChemInform Abstract: Catharoseumine, a New Monoterpenoid Indole Alkaloid Possessing a Peroxy Bridge from Catharanthus roseus.

ChemInform ◽  
2012 ◽  
Vol 43 (29) ◽  
pp. no-no
Author(s):  
Lei Wang ◽  
Hong-Ping He ◽  
Ying-Tong Di ◽  
Yu Zhang ◽  
Xiao-Jiang Hao
Keyword(s):  
Catharanthus Roseus ◽  
Indole Alkaloid ◽  
Monoterpenoid Indole Alkaloid

Catharoseumine, a new monoterpenoid indole alkaloid possessing a peroxy bridge from Catharanthus roseus

2012 ◽  
Vol 53 (13) ◽  
pp. 1576-1578 ◽  
Author(s):  
Lei Wang ◽  
Hong-Ping He ◽  
Ying-Tong Di ◽  
Yu Zhang ◽  
Xiao-Jiang Hao
Keyword(s):  
Catharanthus Roseus ◽  
Indole Alkaloid ◽  
Monoterpenoid Indole Alkaloid

Coordinated regulation of two indole alkaloid biosynthetic genes from Catharanthus roseus by auxin and elicitors

1992 ◽  
Vol 18 (6) ◽  
pp. 1121-1131 ◽  
Author(s):  
Giancarlo Pasquali ◽  
Oscar J. M. Goddijn ◽  
Anthony de Waal ◽  
Robert Verpoorte ◽  
Rob A. Schilperoort ◽  
...  
Keyword(s):  
Catharanthus Roseus ◽  
Indole Alkaloid ◽  
Biosynthetic Genes ◽  
Coordinated Regulation
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