Reduction‐sensitive carrier containing disulfide bond based on Pluronic F68 with cholesterol for drug delivery

2020 ◽  
Vol 70 (1) ◽  
pp. 107-115
Author(s):  
Yichen Zhang ◽  
Xiaoshan Fan ◽  
Yongjie Yu ◽  
Wenqiang Li ◽  
Hongpan Huang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Disulfide Bond ◽  
Pluronic F68

Preparation of Copolymer Paclitaxel Covalently Linked via a Disulfide Bond and Its Application on Controlled Drug Delivery

2012 ◽  
Vol 116 (30) ◽  
pp. 9231-9237 ◽  
Author(s):  
Wulian Chen ◽  
Yuanlin Shi ◽  
Hua Feng ◽  
Ming Du ◽  
Jin Zhong Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Disulfide Bond ◽  
Controlled Drug Delivery ◽  
Covalently Linked

scholarly journals In situ gelling systems based on Pluronic F127/Pluronic F68 formulations for ocular drug delivery

2016 ◽  
Vol 502 (1-2) ◽  
pp. 70-79 ◽  
Author(s):  
Kosai Al Khateb ◽  
Elvira K. Ozhmukhametova ◽  
Marat N. Mussin ◽  
Serzhan K. Seilkhanov ◽  
Tolebai K. Rakhypbekov ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ocular Drug Delivery ◽  
Pluronic F127 ◽  
Pluronic F68 ◽  
In Situ Gelling

Redox-sensitive mesoporous silica nanoparticles functionalized with PEG through a disulfide bond linker for potential anticancer drug delivery

RSC Advances ◽  
2015 ◽  
Vol 5 (73) ◽  
pp. 59576-59582 ◽  
Author(s):  
Huameng Gong ◽  
Zhifei Xie ◽  
Mingxing Liu ◽  
Hongda Zhu ◽  
Honghao Sun
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anticancer Drug ◽  
Disulfide Bond ◽  
Mesoporous Silica Nanoparticles ◽  
Thiol Group ◽  
Anticancer Drug Delivery ◽  
Methoxy Polyethylene Glycol

In this paper, redox-sensitive mesoporous silica nanoparticles (MSNs–SS–PEG) were successfully synthesized using silica nanoparticles modified with a thiol group (MSNs–SH) and thiol-functionalized methoxy polyethylene glycol (MeOPEG–SH).

Disulfide Bond-Responsive Nanotherapeutic Systems for the Effective Payload in Cancer Therapy

2020 ◽  
Vol 26 (41) ◽  
pp. 5353-5361 ◽  
Author(s):  
Pravin Shende ◽  
Gauraja Deshpande
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Disulfide Bond ◽  
Disulfide Bonds ◽  
Drug Delivery Systems ◽  
Biological Fluid ◽  
Neoplastic Cell ◽  
Delivery Systems ◽  
Potential Candidate ◽  
High Concentration

Background: The progressive treatment of cancer using disulfide bond-based therapeutics offers improvement in therapeutic potency of active, reduction in adverse events, prolongation of drug release pattern and on-site action by interacting with neoplastic cell microenvironment. Objective: The objective of this article is to highlight the research carried out on disulfide bond-based drug delivery systems as a potential candidate for cancer treatment. Methods: The article provides an overview of the importance of disulfide bonds in cancer treatment in terms of their properties, mechanism of formation/fragmentation and applications. Properties of disulfide bonds, such as pKa, entropy, and dihedral angle contribute to the structural stability of the bonds in a nanotherapeutic system, while their formation and fragmentation are attributed to the presence of a high concentration of GSH in cancer cells. The article further focuses on various drug delivery systems like dendrimers, liposomes, micelles, etc. involving disulfide cross-linked polymers for the preparation of redox-responsive drug delivery systems. Results: The use of nanotechnology with disulfide bond creates an anticancer drug delivery system with higher target specificity, improved bioavailability, and good therapeutic efficacy. Conclusion: In the near future, the combination of DSB with active, cellular material, stem cell and biological fluid will be considered as a new thrust area for research in healthcare.

Peptide–Drug Conjugate Linked via a Disulfide Bond for Kidney Targeted Drug Delivery

2012 ◽  
Vol 23 (6) ◽  
pp. 1200-1210 ◽  
Author(s):  
Qian Geng ◽  
Xun Sun ◽  
Tao Gong ◽  
Zhi-Rong Zhang
Keyword(s):  
Drug Delivery ◽  
Disulfide Bond ◽  
Targeted Drug Delivery ◽  
Peptide Drug ◽  
Drug Conjugate ◽  
Targeted Drug

scholarly journals Functional polymeric dialdehyde dextrin network capped mesoporous silica nanoparticles for pH/GSH dual-controlled drug release

RSC Advances ◽  
2018 ◽  
Vol 8 (37) ◽  
pp. 20862-20871 ◽  
Author(s):  
Chao Chen ◽  
Wen Sun ◽  
Wenji Yao ◽  
Yibing Wang ◽  
Hanjie Ying ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Disulfide Bond ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Release ◽  
Polymer Shell ◽  
Dual Responsive

A smart pH/GSH dual-responsive drug delivery system by using DAD as a “gatekeeper polymer” to end-cap MSNs via pH-sensitive Schiff bond, whereas DAD polymer shell were cross-linked by GSH-sensitive disulfide bond.

pH-sensitive micelles based on acid-labile pluronic F68–curcumin conjugates for improved tumor intracellular drug delivery

2016 ◽  
Vol 502 (1-2) ◽  
pp. 28-37 ◽  
Author(s):  
Xiao-Bin Fang ◽  
Jin-Ming Zhang ◽  
Xi Xie ◽  
Di Liu ◽  
Cheng-Wei He ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive ◽  
Pluronic F68 ◽  
Intracellular Drug Delivery ◽  
Acid Labile

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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