Deduction of a facile method to construct Antheraea mylitta silk fibroin/gelatin blend films for prospective biomedical applications

2020 ◽  
Vol 70 (1) ◽  
pp. 73-82
Author(s):  
Radhika Batra ◽  
Roli Purwar
Keyword(s):  
Silk Fibroin ◽  
Biomedical Applications ◽  
Antheraea Mylitta ◽  
Blend Films

Silk Fibroin/Hyaluronic Acid Blend Film with Good Water Stability and Cytocompatibility

2013 ◽  
Vol 377 ◽  
pp. 209-214
Author(s):  
Ling Shuang Wang ◽  
Shu Qin Yan ◽  
Ming Zhong Li
Keyword(s):  
Cell Proliferation ◽  
Hyaluronic Acid ◽  
Silk Fibroin ◽  
Biomedical Applications ◽  
Water Resistance ◽  
High Water ◽  
Casting Method ◽  
Blend Ratio ◽  
Blend Films

Stimulating cell proliferation is a challenge in the field of silk fibroin-based biomaterials. In this study, silk fibroin/hyaluronic acid blend films were prepared by a casting method using carbodiimide as a cross-linking agent. Carbodiimide induced silk fibroin to form Silk I crystal structure which was not affected by the presence of hyaluronic acid. The films showed high water resistance. In vitro, the performance of these films was assessed by seeding L929 cells. The results indicated that the silk fibroin/hyaluronic acid blend films with the blend ratio of 80/20 and 60/40 promoted cell proliferation compared with the pure silk fibroin or hyaluronic acid film. These results suggest that silk fibroin/hyaluronic acid blend films are water stable and cytocompatible materials which are expected to be useful in biomedical applications.

Silk Fibroin/Gelatin Blend Films Crosslinked with Enzymes for Biomedical Applications

2013 ◽  
Vol 13 (11) ◽  
pp. 1492-1510 ◽  
Author(s):  
Paola Taddei ◽  
Valeria Chiono ◽  
Anna Anghileri ◽  
Giovanni Vozzi ◽  
Giuliano Freddi ◽  
...  
Keyword(s):  
Silk Fibroin ◽  
Biomedical Applications ◽  
Blend Films

Chitosan/Polyethylene Oxide (PEO) Filled Carbonized Wood Fiber Conductive Composite Film

2020 ◽  
Vol 1010 ◽  
pp. 638-644
Author(s):  
Mohd Pisal Mohd Hanif ◽  
Abd Jalil Jalilah ◽  
Mohd Fadzil Hanim Anisah ◽  
Arumugam Tilagavathy
Keyword(s):  
Electrical Conductivity ◽  
Tensile Strength ◽  
Polyethylene Oxide ◽  
Biomedical Applications ◽  
Wood Fiber ◽  
Conductive Polymer ◽  
Renewable Resource ◽  
Blend Films ◽  
Conductive Composite Film ◽  
Carbonized Wood

Biopolymer-based conductive polymer composites (CPCs) would open up various possibilities in biomedical applications owing to ease of processing, renewable resource and environmentally friendly. However, low mechanical properties are a major issue for their applications. In this study, the investigated the conductivity of chitosan/ PEO blend films filled with carbonized wood fiber (CWF) prepared by solution casting. The effect of CWF was also investigated on tensile properties and their morphological surfaces. The tensile results from different ratios of chitosan/PEO blend films without CWF show that the tensile strength and modulus increased with the increase of chitosan content and chitosan/PEO blend film with 70/30 ratio exhibited the best combination of tensile strength and flexibility. However, a reduction of tensile strength was observed when CWF amount was increased while the modulus of the tensile shows an increment. The film also exhibited higher electrical conductivity as compared to low chitosan ratio. The addition of CWF greatly enhanced the conductivity three-fold from 10-10 to 10-6 S/cm. The electrical conductivity continued to increase with the increase of CWF up to 30wt%. The surface morphology by Scanning Electron Microscopy (SEM) exhibits the absence of phase separation for the blends indicating good miscibility between the PEO and chitosan. Incorporation of CWF into the blend films at 5wt% showed agglomeration. However, the increase of CWF created larger agglomerations that formed conductive pathways resulting in improved conductivity. FTIR analysis suggested that intermolecular interactions occurred between chitosan and PEO while CWF interacts more with the protons of PEO.

scholarly journals How to Improve Physico-Chemical Properties of Silk Fibroin Materials for Biomedical Applications?—Blending and Cross-Linking of Silk Fibroin—A Review

Materials ◽  
2021 ◽  
Vol 14 (6) ◽  
pp. 1510
Author(s):  
Sylwia Grabska-Zielińska ◽  
Alina Sionkowska
Keyword(s):  
Silk Fibroin ◽  
Biomedical Applications ◽  
Magnetic Particles ◽  
Chemical Properties ◽  
Ternary Mixtures ◽  
Cross Linking ◽  
Advantages And Disadvantages ◽  
Physico Chemical ◽  
Binary And Ternary Mixtures ◽  
To Receive

This review supplies a report on fresh advances in the field of silk fibroin (SF) biopolymer and its blends with biopolymers as new biomaterials. The review also includes a subsection about silk fibroin mixtures with synthetic polymers. Silk fibroin is commonly used to receive biomaterials. However, the materials based on pure polymer present low mechanical parameters, and high enzymatic degradation rate. These properties can be problematic for tissue engineering applications. An increased interest in two- and three-component mixtures and chemically cross-linked materials has been observed due to their improved physico-chemical properties. These materials can be attractive and desirable for both academic, and, industrial attention because they expose improvements in properties required in the biomedical field. The structure, forms, methods of preparation, and some physico-chemical properties of silk fibroin are discussed in this review. Detailed examples are also given from scientific reports and practical experiments. The most common biopolymers: collagen (Coll), chitosan (CTS), alginate (AL), and hyaluronic acid (HA) are discussed as components of silk fibroin-based mixtures. Examples of binary and ternary mixtures, composites with the addition of magnetic particles, hydroxyapatite or titanium dioxide are also included and given. Additionally, the advantages and disadvantages of chemical, physical, and enzymatic cross-linking were demonstrated.

scholarly journals Comparative Study of Silk Fibroin-Based Hydrogels and Their Potential as Material for 3-Dimensional (3D) Printing

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3887
Author(s):  
Watcharapong Pudkon ◽  
Chavee Laomeephol ◽  
Siriporn Damrongsakkul ◽  
Sorada Kanokpanont ◽  
Juthamas Ratanavaraporn
Keyword(s):  
3D Printing ◽  
Silk Fibroin ◽  
Biomedical Applications ◽  
Mechanical Stability ◽  
Three Dimensional ◽  
Structure Stability ◽  
3 Dimensional ◽  
Critical Technology ◽  
Box Structure ◽  
High Degree

Three-dimensional (3D) printing is regarded as a critical technology in material engineering for biomedical applications. From a previous report, silk fibroin (SF) has been used as a biomaterial for tissue engineering due to its biocompatibility, biodegradability, non-toxicity and robust mechanical properties which provide a potential as material for 3D-printing. In this study, SF-based hydrogels with different formulations and SF concentrations (1–3%wt) were prepared by natural gelation (SF/self-gelled), sodium tetradecyl sulfate-induced (SF/STS) and dimyristoyl glycerophosphorylglycerol-induced (SF/DMPG). From the results, 2%wt SF-based (2SF) hydrogels showed suitable properties for extrusion, such as storage modulus, shear-thinning behavior and degree of structure recovery. The 4-layer box structure of all 2SF-based hydrogel formulations could be printed without structural collapse. In addition, the mechanical stability of printed structures after three-step post-treatment was investigated. The printed structure of 2SF/STS and 2SF/DMPG hydrogels exhibited high stability with high degree of structure recovery as 70.4% and 53.7%, respectively, compared to 2SF/self-gelled construct as 38.9%. The 2SF/STS and 2SF/DMPG hydrogels showed a great potential to use as material for 3D-printing due to its rheological properties, printability and structure stability.

scholarly journals Oxygen Permeability of Silk Fibroin Hydrogels and Their Use as Materials for Contact Lenses: A Purposeful Analysis

Gels ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. 58
Author(s):  
Traian V. Chirila
Keyword(s):  
Tissue Engineering ◽  
Bombyx Mori ◽  
Silk Fibroin ◽  
Biomedical Applications ◽  
Oxygen Permeability ◽  
Contact Lenses ◽  
The Past ◽  
Fibrous Protein ◽  
Silk Moth ◽  
Bombyx Mori Silk

Fibroin is a fibrous protein that can be conveniently isolated from the silk cocoons produced by the larvae of Bombyx mori silk moth. In its form as a hydrogel, Bombyx mori silk fibroin (BMSF) has been employed in a variety of biomedical applications. When used as substrates for biomaterial-cells constructs in tissue engineering, the oxygen transport characteristics of the BMSF membranes have proved so far to be adequate. However, over the past three decades the BMSF hydrogels have been proposed episodically as materials for the manufacture of contact lenses, an application that depends on substantially elevated oxygen permeability. This review will show that the literature published on the oxygen permeability of BMSF is both limited and controversial. Additionally, there is no evidence that contact lenses made from BMSF have ever reached commercialization. The existing literature is discussed critically, leading to the conclusion that BMSF hydrogels are unsuitable as materials for contact lenses, while also attempting to explain the scarcity of data regarding the oxygen permeability of BMSF. To the author’s knowledge, this review covers all publications related to the topic.

Novel Alginate Frankincense Oil Blend Films for Biomedical Applications

2019 ◽  
Vol 90 (2) ◽  
pp. 303-312
Author(s):  
Mona A. Saied ◽  
Nagwa A. Kamel ◽  
Azza A. Ward ◽  
Amal E. Abd El-kader
Keyword(s):  
Biomedical Applications ◽  
Blend Films ◽  
Oil Blend

Preparation and characterization of silk fibroin/hydroxypropyl methyl cellulose (HPMC) blend films

2015 ◽  
Vol 16 (8) ◽  
pp. 1734-1741 ◽  
Author(s):  
G. Rajesha Shetty ◽  
B. Lakshmeesha Rao ◽  
S. Asha ◽  
Youjiang Wang ◽  
Y. Sangappa
Keyword(s):  
Silk Fibroin ◽  
Methyl Cellulose ◽  
Hydroxypropyl Methyl Cellulose ◽  
Blend Films

Milled non-mulberry silk fibroin microparticles as biomaterial for biomedical applications

2015 ◽  
Vol 81 ◽  
pp. 31-40 ◽  
Author(s):  
Nandana Bhardwaj ◽  
Rangam Rajkhowa ◽  
Xungai Wang ◽  
Dipali Devi
Keyword(s):  
Silk Fibroin ◽  
Biomedical Applications
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