Effect of solvent type on preparation of ethyl cellulose microparticles by solvent evaporation method with double emulsion system using focused beam reflectance measurement

2017 ◽  
Vol 66 (11) ◽  
pp. 1448-1455 ◽  
Author(s):  
Muhaimin ◽  
Roland Bodmeier
Keyword(s):  
Ethyl Cellulose ◽  
Double Emulsion ◽  
Solvent Evaporation ◽  
Emulsion System ◽  
Solvent Evaporation Method ◽  
Reflectance Measurement ◽  
Evaporation Method ◽  
Effect Of Solvent ◽  
Solvent Type ◽  
Focused Beam

scholarly journals Effect of different surface active polysaccharide derivatives on the formation of ethyl cellulose particles by the emulsion-solvent evaporation method

Cellulose ◽  
2018 ◽  
Vol 25 (12) ◽  
pp. 6901-6922 ◽  
Author(s):  
Mojca Božič ◽  
Thomas Elschner ◽  
Doris Tkaučič ◽  
Matej Bračič ◽  
Silvo Hribernik ◽  
...  
Keyword(s):  
Ethyl Cellulose ◽  
Solvent Evaporation ◽  
Solvent Evaporation Method ◽  
Evaporation Method ◽  
Surface Active ◽  
Polysaccharide Derivatives

scholarly journals A detailed view of PLGA-mPEG microsphere formation by double emulsion solvent evaporation method

2015 ◽  
Vol 33 (7) ◽  
pp. 955-963 ◽  
Author(s):  
Shui-bin Feng ◽  
De-hao Fu ◽  
Lei Nie ◽  
Peng Zou ◽  
Jin-ping Suo
Keyword(s):  
Double Emulsion ◽  
Solvent Evaporation ◽  
Solvent Evaporation Method ◽  
Evaporation Method

scholarly journals Microencapsulation of Fucoxanthin by Water-in-Oil-in-Water (W/O/W) Double Emulsion Solvent Evaporation Method: A Review

2014 ◽  
Vol 9 (3) ◽  
pp. 137 ◽  
Author(s):  
Dedi Noviendri
Keyword(s):  
Cell Line ◽  
Colloidal Stability ◽  
Double Emulsion ◽  
Solvent Evaporation ◽  
Human Lung Cancer ◽  
Drug Candidate ◽  
Human Leukemia ◽  
Solvent Evaporation Method ◽  
Evaporation Method ◽  
Oil In Water

Fucoxanthin is a major xanthophyll present in brown seaweeds such as Sargassum binderi, S. duplicatum, Turbinaria turbinata, Padina australis, Undaria pinnatifida and Hijkia fusiformis. This carotenoid has a unique structure including oxygenic functional group such as, two hydroxy, keto, epoxy (5,6-monoepoxide), and an allenic bond. Fucoxanthin has some anticancer activities such as, exhibits inhibitory property on colon cancer cells and human hepatic carcinoma HepG2 cell line. This xanthophyll also induces apoptosis of human leukemia cancer HL-60 cells, human prostate cancer PC-3 cell, human lung cancer H1299 cell line etc. Unfortunately, the poor solubility of this carotenoid in water hinders it to be a drug candidate. Fucoxanthin is also a pigment that is sensitive to temperature and light. One of the possible ways to circumvent the problem with light and temperature is by microencapsulating it. Microencapsulation (ME) in biodegradable polymers, e.g. poly(D,L-lactic-co-glycolic acid) (PLGA) is a promising approach to protect any potential drug from rapid degradation. Solvent evaporation method is the most popular technique of preparing PLGA microsphere (MS) and this technique has been extensively studied in recent years for the preparation of MS. In the water-in-oil-in-water (w/o/w) double emulsion solvent evaporation method, stability of the primary emulsion (PE) is a critical factor. When the PE is unstable, encapsulation efficiency (EE) is low. Stability of PE can be enhanced by including emulsifying agent or stabilizers such as polyvinyl alcohol (PVA). The presence of a stabilizer/ emulsifier plays a significant role in influencing particle size (PS), external morphology of microsphere and colloidal stability.  

Sign in / Sign up

Export Citation Format

Share Document