Star-shaped amphiphilic block polyurethane with pentaerythritol core for a hydrophobic drug delivery carrier

2016 ◽  
Vol 65 (5) ◽  
pp. 551-558 ◽  
Author(s):  
Shihai Wang ◽  
Yu Zhou ◽  
Bo Zhuang ◽  
Peng Zheng ◽  
Hongxiang Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hydrophobic Drug ◽  
Drug Delivery Carrier

scholarly journals A comprehensive review on polymeric micelles: a promising drug delivery carrier

2021 ◽  
Vol 10 (3) ◽  
pp. 102-107
Author(s):  
Ajay Kumar
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Polymeric Micelles ◽  
Delivery Systems ◽  
Hydrophobic Drug ◽  
Drug Release Profile ◽  
Physiological Conditions ◽  
Drug Molecules ◽  
Drug Delivery Carrier

The main aim of drug delivery systems is to regulate the rate of drug release as per the patient's physiological conditions as well as the progression of the illness or as per the circadian rhythms. To achieve such objectives, the new drug delivery systems have been developed to provide the drug release profile, which is based on each patient's needs. Different researches have been done to create drug delivery carriers, focusing on targeting and delivering hydrophobic drug molecules. This review focuses on Polymeric Micelles as the promising drug delivery carrier due to its high stability, protective property against the harsh gastrointestinal environment.

scholarly journals Bioinspired urease-powered micromotor as an active oral drug delivery carrier in stomach

2021 ◽  
Author(s):  
Hyunsik Choi ◽  
Sang Hoon Jeong ◽  
Tae Yeon Kim ◽  
Jeeyoon Yi ◽  
Sei Kwang Hahn
Keyword(s):  
Drug Delivery ◽  
Oral Drug Delivery ◽  
Oral Drug ◽  
Drug Delivery Carrier

Magnetic Nanoparticles Grafted with Cyclodextrin for Hydrophobic Drug Delivery

2007 ◽  
Vol 19 (25) ◽  
pp. 6345-6349 ◽  
Author(s):  
Shashwat S. Banerjee ◽  
Dong-Hwang Chen
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Hydrophobic Drug

Nanoparticulate Drug Delivery Systems: An update

2021 ◽  
pp. 312-316
Author(s):  
Pandey Swarnima ◽  
Sushant Kumar
Keyword(s):  
Drug Delivery ◽  
Carrying Capacity ◽  
Drug Delivery Systems ◽  
High Specificity ◽  
Delivery Systems ◽  
Classification Methods ◽  
Hydrophobic Drug ◽  
Drug Molecules ◽  
Conventional Drug ◽  
Novel Drug

The paper is aimed to provide a comprehensive review on nanoparticles, methods of preparation, applications in drug delivery. In recent years, there has been an exponential interest within the development of novel drug delivery systems using nanoparticles. Nanoparticles offers significant advantages over the conventional drug delivery in terms of high stability, high specificity, high drug carrying capacity, ability for controlled release, possibility to use in several route of administration and therefore the capability to deliver both hydrophilic and hydrophobic drug molecules. This review focuses on classification, methods of preparation, characterization, application, advantages of nanoparticles and health perspectives.

scholarly journals A Micellar-Hydrogel Nanogrid from a UV Crosslinked Inulin Derivative for the Simultaneous Delivery of Hydrophobic and Hydrophilic Drugs

Pharmaceutics ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 97 ◽  
Author(s):  
Delia Mandracchia ◽  
Adriana Trapani ◽  
Sara Perteghella ◽  
Cinzia Di Franco ◽  
Maria Torre ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Beclomethasone Dipropionate ◽  
Polymeric Micelles ◽  
Hydrophobic Drugs ◽  
Hydrophobic Drug ◽  
Hydrophilic Drugs ◽  
Uv Crosslinking ◽  
Colon Drug Delivery ◽  
Materials Used ◽  
Simultaneous Delivery

Hydrogels are among the most common materials used in drug delivery, as polymeric micelles are too. They, preferentially, load hydrophilic and hydrophobic drugs, respectively. In this paper, we thought to combine the favorable behaviors of both hydrogels and polymeric micelles with the specific aim of delivering hydrophilic and hydrophobic drugs for dual delivery in combination therapy, in particular for colon drug delivery. Thus, we developed a hydrogel by UV crosslinking of a methacrylated (MA) amphiphilic derivative from inulin (INU) (as known INU is specifically degraded into the colon) and vitamin E (VITE), called INVITEMA. The methacrylated micelles were physicochemically characterized and subjected to UV irradiation to form what we called the “nanogrids”. The INVITEMA nanogrids were characterized by DSC, SEM, TEM, water uptake and beclomethasone dipropionate (BDP) release. In particular, the release of the hydrophobic drug was specifically assessed to verify that it can spread along the hydrophilic portions and, therefore, effectively released. These systems can open new pharmaceutical applications for known hydrogels or micelle systems, considering that in literature only few examples are present.

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