Size Exclusion Chromatography of Poly(ethylene glycol)

1986 ◽  
Vol 18 (6) ◽  
pp. 391-393 ◽  
Author(s):  
Olgun Güven
Keyword(s):  
Ethylene Glycol ◽  
Size Exclusion Chromatography ◽  
Size Exclusion ◽  
Poly Ethylene Glycol ◽  
Exclusion Chromatography ◽  
Poly Ethylene

Synthesis and Application of New Photocrosslinkers for Poly(ethylene glycol)

2012 ◽  
Vol 65 (2) ◽  
pp. 193 ◽  
Author(s):  
Hakim Mehenni ◽  
Vincent Pourcelle ◽  
Jean-François Gohy ◽  
Jacqueline Marchand-Brynaert
Keyword(s):  
Polyethylene Glycol ◽  
Ethylene Glycol ◽  
Functional Polymers ◽  
Size Exclusion ◽  
Poly Ethylene Glycol ◽  
Polymer Backbone ◽  
Exclusion Chromatography ◽  
Exogenous Agents ◽  
Commercial Sources ◽  
Poly Ethylene

Photocrosslinking of polyethylene glycol (PEG) using exogenous agents is a convenient way to produce branched PEG from commercial sources thus avoiding the tricky synthesis of new reactive and functional polymers. In this study, we synthesized two series of new photocrosslinkers, i.e. bis-fluorophenyl azide and bis-trifluoromethyl diazirine, which under soft UV-irradiation produce reactive species (i.e. nitrene and carbene respectively) that insert into the C–H bond of the polymer backbone, building new bridges between macromolecular chains. These photocrosslinkers are different in terms of behaviour under irradiation and affinity for the target substrate (i.e. PEG). Thus, practical conditions for photocrosslinking of a 10-kDa PEG were studied and followed by NMR and size-exclusion chromatography. In particular, we investigated irradiation in bulk or in solvent, at different irradiation times, with several concentrations of PEG and photolinkers. Finally, we were able to design a procedure to obtain soluble crosslinked PEGs of 300 kDa.

scholarly journals Some Guidelines for the Synthesis and Melting Characterization of Azide Poly(ethylene glycol) Derivatives

Polymers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1269
Author(s):  
Daniel González-Fernández ◽  
Mercedes Torneiro ◽  
Massimo Lazzari
Keyword(s):  
Molecular Weight ◽  
Ethylene Glycol ◽  
Average Molecular Weight ◽  
Size Exclusion ◽  
Degree Of Crystallinity ◽  
Specific Class ◽  
Poly Ethylene Glycol ◽  
End Groups ◽  
Poly Ethylene

We provide fundamental guidelines in the form of a tutorial to be taken into account for the preparation and characterization of a specific class of poly(ethylene glycol) (PEG) derivatives, namely azide-terminated PEGs. Special attention is given to the effect of these chain end groups and their precursors on properties affecting the PEGylation of proteins, nanoparticles and nanostructured surfaces. Notwithstanding the presence of 13C satellite peaks, we show that 1H NMR enables not only the routine quantitative determination of chain-end substitution, but is also a unique method to calculate the absolute number average molecular weight of PEG derivatives. In the use of size exclusion chromatography to get molecular weight distributions, we highlight the importance of distinguishing between eventual secondary reactions involving molecular weight changes and the formation of PEG complexes due to residual amounts of metal cations from reactants. Finally, we show that azide end groups affect PEG melting behavior. In contrast to oxygen-containing end groups, azides do not interact with PEG segments, thus inducing defect formation in the crystal lattice and the reduction of crystal sizes. Melting temperature and degree of crystallinity decrease become especially relevant for PEGs with very low molecular weight, and its comprehension is particularly important for solid-state applications.

Size-exclusion chromatography of poly(ethylene 2,6-naphthalate)

2012 ◽  
Vol 1256 ◽  
pp. 129-135 ◽  
Author(s):  
T.H. Mourey ◽  
L.A. Slater ◽  
R.C. Galipo ◽  
D.L. Janes ◽  
R.E. Moody
Keyword(s):  
Size Exclusion Chromatography ◽  
Size Exclusion ◽  
Exclusion Chromatography ◽  
Poly Ethylene

Mechanical properties and hydrolytic degradation of methoxy poly(ethylene glycol)-b-poly(DL-lactide-coglycolide- co-ε-caprolactone) diblock copolymer films

e-Polymers ◽  
2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Nongnit Morakot ◽  
Jirasak Threeprom ◽  
Yodthong Baimark
Keyword(s):  
Mechanical Properties ◽  
Weight Loss ◽  
Ethylene Glycol ◽  
Diblock Copolymers ◽  
Hydrolytic Degradation ◽  
Size Exclusion ◽  
Block Length ◽  
Poly Ethylene Glycol ◽  
Scanning Calorimetry ◽  
Poly Ethylene

AbstractBiodegradable films of methoxy poly(ethylene glycol)-b-poly(DL-lactideco- glycolide-co-ε-caprolactone) diblock copolymers (MPEG-b-PDLLGCL) were prepared by solution casting method. Effects of MPEG block length and DLL:G:CL ratio of the MPEG-b-PDLLGCL films on their mechanical properties and hydrolytic degradation were studied and discussed. It was found that the mechanical properties of films were strongly dependent on glass transition temperatures (Tg) of the diblock copolymers. The hydrolytic degradation was investigated in phosphatebuffered solution at 37°C. The degraded films were characterized using gravimetry (%water uptake and %weight loss), 1H-NMR spectroscopy, differential scanning calorimetry and size exclusion chromatography. The %weight loss of the degraded films increased and molecular weight decreased on increasing the MPEG block length and incorporating the G and CL units, according to their %water uptakes. The MPEG content of the degraded film decreased and the Tg increased with hydrolytic degradation time.

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