Preparation of magnetic poly(lactic-co -glycolic acid) microspheres featuring monodispersity and controllable particle size using a microchannel device

2015 ◽  
Vol 64 (10) ◽  
pp. 1425-1432 ◽  
Author(s):  
Hengdi Zhang ◽  
Lili Hu ◽  
Yi Zhong ◽  
Yan Luo
Keyword(s):  
Particle Size ◽  
Glycolic Acid ◽  
Microchannel Device ◽  
Controllable Particle Size

scholarly journals Translating the fabrication of protein-loaded poly(lactic-co-glycolic acid) nanoparticles from bench to scale-independent production using microfluidics

2020 ◽  
Vol 10 (3) ◽  
pp. 582-593 ◽  
Author(s):  
Carla B. Roces ◽  
Dennis Christensen ◽  
Yvonne Perrie
Keyword(s):  
Particle Size ◽  
Glycolic Acid ◽  
Polymeric Nanoparticles ◽  
Physicochemical Characteristics ◽  
European Medicines Agency ◽  
Protein Encapsulation ◽  
Human Use ◽  
Rate Ratios ◽  
The Impact ◽  
Process Controls

AbstractIn the formulation of nanoparticles, poly(lactic-co-glycolic acid) (PLGA) is commonly employed due to its Food and Drug Administration and European Medicines Agency approval for human use, its ability to encapsulate a variety of moieties, its biocompatibility and biodegradability and its ability to offer a range of controlled release profiles. Common methods for the production of PLGA particles often adopt harsh solvents, surfactants/stabilisers and in general are multi-step and time-consuming processes. This limits the translation of these drug delivery systems from bench to bedside. To address this, we have applied microfluidic processes to develop a scale-independent platform for the manufacture, purification and monitoring of nanoparticles. Thereby, the influence of various microfluidic parameters on the physicochemical characteristics of the empty and the protein-loaded PLGA particles was evaluated in combination with the copolymer employed (PLGA 85:15, 75:25 or 50:50) and the type of protein loaded. Using this rapid production process, emulsifying/stabilising agents (such as polyvinyl alcohol) are not required. We also incorporate in-line purification systems and at-line particle size monitoring. Our results demonstrate the microfluidic control parameters that can be adopted to control particle size and the impact of PLGA copolymer type on the characteristics of the produced particles. With these nanoparticles, protein encapsulation efficiency varies from 8 to 50% and is controlled by the copolymer of choice and the production parameters employed; higher flow rates, combined with medium flow rate ratios (3:1), should be adopted to promote higher protein loading (% wt/wt). In conclusion, herein, we outline the process controls for the fabrication of PLGA polymeric nanoparticles incorporating proteins in a rapid and scalable manufacturing process.

scholarly journals Design and Characterizations of Inhalable Poly(lactic-co-glycolic acid) Microspheres Prepared by the Fine Droplet Drying Process for a Sustained Effect of Salmon Calcitonin

Molecules ◽  
2020 ◽  
Vol 25 (6) ◽  
pp. 1311 ◽  
Author(s):  
Hideyuki Sato ◽  
Aiko Tabata ◽  
Tatsuru Moritani ◽  
Tadahiko Morinaga ◽  
Takahiro Mizumoto ◽  
...  
Keyword(s):  
Particle Size ◽  
Sustained Release ◽  
Salmon Calcitonin ◽  
Glycolic Acid ◽  
Pharmacological Action ◽  
Conformational Structure ◽  
Intratracheal Administration ◽  
Fine Droplet ◽  
Droplet Drying

The present study aimed to develop inhalable poly (lactic-co-glycolic acid) (PLGA)-based microparticles of salmon calcitonin (sCT) for sustained pharmacological action by the fine droplet drying (FDD) process, a novel powderization technique employing printing technologies. PLGA was selected as a biodegradable carrier polymer for sustained-release particles of sCT (sCT/SR), and physicochemical characterizations of sCT/SR were conducted. To estimate the in vivo efficacy of the sCT/SR respirable powder (sCT/SR-RP), plasma calcium levels were measured after intratracheal administration in rats. The particle size of sCT/SR was 3.6 µm, and the SPAN factor, one of the parameters to present the uniformity of particle size distribution, was calculated to be 0.65. In the evaluation of the conformational structure of sCT, no significant changes were observed in sCT/SR even after the FDD process. The drug release from sCT/SR showed a biphasic pattern with an initial burst and slow diffusion in simulated lung fluid. sCT/SR-RP showed fine inhalation performance, as evidenced by a fine particle fraction value of 28% in the cascade impactor analysis. After the insufflation of sCT samples (40 µg-sCT/kg) in rats, sCT/SR-RP could enhance and prolong the hypocalcemic action of sCT possibly due to the sustained release and pulmonary absorption of sCT. From these observations, the strategic application of the FDD process could be efficacious to provide PLGA-based inhalable formulations of sCT, as well as other therapeutic peptides, to enhance their biopharmaceutical potentials.

Preparation of high silica chabazite with controllable particle size

2014 ◽  
Vol 195 ◽  
pp. 294-302 ◽  
Author(s):  
Zebastian Bohström ◽  
Bjørnar Arstad ◽  
Karl Petter Lillerud
Keyword(s):  
Particle Size ◽  
High Silica ◽  
Controllable Particle Size

scholarly journals Synthesis of High-Quality Carboxyl End-Functionalized Poly(3-hexylthiophene)/CdSe Nanocomposites

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
He-Ping Shi ◽  
Da-Wei Lin ◽  
Rui-feng Wu
Keyword(s):  
Particle Size ◽  
Charge Transfer ◽  
Crystalline Structure ◽  
Environmentally Friendly ◽  
Cdse Nanocrystals ◽  
High Quality ◽  
Efficient Charge ◽  
Controllable Particle Size ◽  
Better Than

Carboxyl end-functionalized poly(3-hexylthiophene) (P3HT-COOH) was grafted chemically with CdSe nanocrystals (NCs) by a phosphine-free method. The particle quality of P3HT-COOH/CdSe nanocomposites was better than that of P3HT/CdSe nanocomposites, which were synthesized using the same method. Nanocrystals with controllable particle size exhibited a wurtzite crystalline structure and showed excellent nanocrystal dispersion in the P3HT-COOH matrix. Photoluminescence (PL) characterization performed on nanocomposites suggested the efficient charge transfer at the P3HT-COOH/CdSe interface. This approach based on the phosphine-free method is not only environmentally friendly but also highly efficient.

Poly (lactic-co-glycolic acid) particles prepared by microfluidics and conventional methods. Modulated particle size and rheology

2015 ◽  
Vol 441 ◽  
pp. 90-97 ◽  
Author(s):  
Aurora Perez ◽  
Rebeca Hernández ◽  
Diego Velasco ◽  
Dan Voicu ◽  
Carmen Mijangos
Keyword(s):  
Particle Size ◽  
Glycolic Acid ◽  
Conventional Methods

scholarly journals FORMULATION AND EVALUATION OF ISORHAMNETIN LOADED POLY LACTIC-CO-GLYCOLIC ACID NANOPARTICLES

2017 ◽  
Vol 10 (11) ◽  
pp. 177
Author(s):  
Kandakumar Settu ◽  
Manju Vaiyapuri
Keyword(s):  
Particle Size ◽  
Glycolic Acid ◽  
Polymeric Nanoparticles ◽  
Double Emulsion ◽  
Spherical Shape ◽  
Particle Size Analysis ◽  
Size Analysis ◽  
Characteristic Variety ◽  
Sem Image ◽  
Flexible Technology

  Objective: The aim of the present study was formulation and evaluation of isorhamnetin loaded poly lactic-co-glycolic acid (PLGA) polymeric nanoparticles (NPs).Methods: The present study was designed to incorporate the isorhamnetin in PLGA formulation by double emulsion solvent evaporation method, which offers a dynamic and flexible technology for enhancing drug solubility due to their biphasic characteristic, variety in design, composition and assembly. Synthesized isorhamnetin-PLGA NPs were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and particle size analyzer. We tested the efficacy of isorhamnetin-PLGA NPs in HepG2 cell lines.Results: From the FTIR result, we concluded that -C-N-, -C=C-, N-H, C-N, N-O, O-H, and C-H are the functional groups present in isorhamnetin-PLGA NPs, SEM image shows spherical shape of particles. The particle size analysis result shows 255-342 nm range of particles. Isorhamnetin-PLGA NPs significantly enhanced (p<0.05) the antiproliferative effect when compared to the plain drug.Conclusion: This study concluded that the newly formulated NP drug delivery systems of isorhamnetin provided an insight into the therapeutic effectiveness of the designed formulation for the treatment of chemotherapy.

Water-Based Synthesis of Zeolitic Imidazolate Framework-90 (ZIF-90) with a Controllable Particle Size

2013 ◽  
Vol 19 (34) ◽  
pp. 11139-11142 ◽  
Author(s):  
Fa-Kuen Shieh ◽  
Shao-Chun Wang ◽  
Sin-Yen Leo ◽  
Kevin C.-W. Wu
Keyword(s):  
Particle Size ◽  
Zeolitic Imidazolate Framework ◽  
Water Based ◽  
Controllable Particle Size
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