scholarly journals PAH clearance after renal ischemia and reperfusion is a function of impaired expression of basolateral Oat1 and Oat3

2014 ◽  
Vol 2 (2) ◽  
pp. e00243 ◽  
Author(s):  
Ariane Bischoff ◽  
Michael Bucher ◽  
Michael Gekle ◽  
Christoph Sauvant
Keyword(s):  
Renal Ischemia ◽  
Ischemia And Reperfusion ◽  
Pah Clearance

scholarly journals Kidney ischemia and reperfunsion syndrome: effect of lidocaine and local postconditioning

2016 ◽  
Vol 43 (5) ◽  
pp. 348-353 ◽  
Author(s):  
IGOR NAGAI YAMAKI ◽  
RUY VICTOR SIMÕES PONTES ◽  
FELIPE LOBATO DA SILVA COSTA ◽  
VITOR NAGAI YAMAKI ◽  
RENAN KLEBER COSTA TEIXEIRA ◽  
...  
Keyword(s):  
Ischemia Reperfusion ◽  
Serum Levels ◽  
Saline Group ◽  
Renal Ischemia ◽  
Ischemic Postconditioning ◽  
Control Group ◽  
Ischemia And Reperfusion ◽  
Lidocaine Group ◽  
Group 5 ◽  
Group 2

ABSTRACT Objective: to evaluate the effects of blocking the regulation of vascular tone on the ischemia and reperfusion syndrome in rats through the use of lidocaine in the postconditioning technique. Methods: we randomized 35 rats into seven groups of five animals: Group 1- Control; Group 2- Ischemia and Reperfusion; Group 3- Ischemia, Reperfusion and Saline; Group 4- Ischemic Postconditioning; Group 5- Ischemic Postconditioning and Saline; Group 6- Lidocaine; Group 7- Ischemic Postconditioning and Lidocaine. Except for the control group, all the others were submitted to renal ischemia for 30 minutes. In postconditioning groups, we performed ischemia and reperfusion cycles of five minutes each, applied right after the main ischemia. In saline and lidocaine groups, we instilled the substances at a rate of two drops per minute. To compare the groups, we measured serum levels of urea and creatinine and also held renal histopathology. Results: The postconditioning and postconditioning + lidocaine groups showed a decrease in urea and creatinine values. The lidocaine group showed only a reduction in creatinine values. In histopathology, only the groups submitted to ischemic postconditioning had decreased degree of tubular necrosis. Conclusion: Lidocaine did not block the effects of postconditioning on renal ischemia reperfusion syndrome, and conferred better glomerular protection when applied in conjunction with ischemic postconditioning.

In vivo spectroscopic monitoring of renal ischemia and reperfusion in a rat model

2006 ◽  
Author(s):  
Rajesh N. Raman ◽  
Christopher D. Pivetti ◽  
Dennis L. Matthews ◽  
Christoph Troppmann ◽  
Stavros G. Demos
Keyword(s):  
Rat Model ◽  
Renal Ischemia ◽  
Ischemia And Reperfusion ◽  
Spectroscopic Monitoring

scholarly journals TonEBP/OREBP is activated by hypoxia: Role in renal Ischemia and Reperfusion

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
CARLOS E IRARRAZABAL ◽  
Sandra Villanueva ◽  
Luis Michea ◽  
Juan E Carreno ◽  
Mauricio Lozano ◽  
...  
Keyword(s):  
Renal Ischemia ◽  
Ischemia And Reperfusion

A Preoperative Protein Free Diet Protects Against Renal Ischemia and Reperfusion Injury

2012 ◽  
Vol 94 (10S) ◽  
pp. 1145
Author(s):  
T. Saat ◽  
T. van Ginhoven ◽  
M. Verweij ◽  
J. N.M. IJzermans ◽  
J. H.J. Hoeijmakers ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Renal Ischemia ◽  
Ischemia And Reperfusion ◽  
Ischemia And Reperfusion Injury ◽  
Protein Free Diet

scholarly journals Alprostadil attenuates inflammatory aspects and leucocytes adhesion on renal ischemia and reperfusion injury in rats

2014 ◽  
Vol 29 (suppl 2) ◽  
pp. 55-60 ◽  
Author(s):  
Bruno Leonardo de Freitas Soares ◽  
Maria Andréia Lopes de Freitas ◽  
Edna Frasson de Souza Montero ◽  
Guilherme Benjamin Brandão Pitta ◽  
Fausto Miranda Júnior
Keyword(s):  
Reperfusion Injury ◽  
Renal Ischemia ◽  
Ischemia And Reperfusion ◽  
Ischemia And Reperfusion Injury

scholarly journals Renal ischemia in the rat stimulates glomerular nitric oxide synthesis

2001 ◽  
Vol 280 (3) ◽  
pp. R771-R779 ◽  
Author(s):  
José M. Valdivielso ◽  
Carlos Crespo ◽  
José R. Alonso ◽  
Carlos Martı́nez-Salgado ◽  
Nelida Eleno ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Structural Damage ◽  
Renal Damage ◽  
Protective Role ◽  
Renal Ischemia ◽  
No Production ◽  
Ischemia And Reperfusion ◽  
Nitric Oxide Synthesis ◽  
Cgmp Production ◽  
Synthesis Activity

Renal ischemia in humans and in experimental animals is associated with a complex and possibly interrelated series of events. In this study, we have investigated the glomerular nitric oxide (NO) production after renal ischemia. Unilateral or bilateral renal ischemia was induced in Wistar rats by clamping one or both renal arteries. NO production was assessed by measuring glomerular production of nitrite, a stable end product of NO catabolism, and NO-dependent glomerular cGMP production and by assessing the glomerular NADPH diaphorase (ND) activity, an enzymatic activity that colocalizes with NO-synthesis activity. Furthermore, we determined the isoform of NO synthase (NOS) implicated in NO synthesis by Western blot and immunohistochemistry. Glomeruli from rats with bilateral ischemia showed elevated glomerular nitrite and cGMP production. Besides, glomeruli from this group of rats showed an increased ND activity, whereas glomeruli from the ischemic and nonischemic rats with unilateral ischemia did not show this increase in nitrite, cGMP, and ND activity. In addition, glomeruli from ischemic kidneys showed an increased expression of endothelial NOS without changes in the inducible isoform. Addition ofl-NAME in the drinking water induced a higher increase in the severity of the functional and structural damage in rats with bilateral ischemia than in rats with unilateral ischemia and in sham-operated animals. We can conclude that after renal ischemia, there is an increased glomerular NO synthesis subsequent to an activation of endothelial NOS that plays a protective role in the renal damage induced by ischemia and reperfusion.

658Expression of VEGF and thrombospondin-1 following renal ischemia and reperfusion in rat

2005 ◽  
Vol 4 (3) ◽  
pp. 167
Author(s):  
K. Song ◽  
H.S. Kim ◽  
Y. Chug ◽  
S.K. Oh ◽  
J.M. Lee ◽  
...  
Keyword(s):  
Renal Ischemia ◽  
Ischemia And Reperfusion ◽  
Thrombospondin 1

Heme oxygenase 1 and renal ischemia and reperfusion injury: The impact of immunosuppressive drug

2006 ◽  
Vol 6 (13-14) ◽  
pp. 1966-1972 ◽  
Author(s):  
Giselle Martins Gonçalves ◽  
Marcos Antônio Cenedeze ◽  
Carla Quarim Feitoza ◽  
Carolina Batista de Paula ◽  
Georgia Daniela Macusso ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Heme Oxygenase ◽  
Immunosuppressive Drug ◽  
Renal Ischemia ◽  
Heme Oxygenase 1 ◽  
Ischemia And Reperfusion ◽  
Ischemia And Reperfusion Injury ◽  
The Impact
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