NONMEM population pharmacokinetics and Monte Carlo dosing simulations of imipenem in critically ill patients with life‐threatening severe infections during support with or without extracorporeal membrane oxygenation in an intensive care unit

2021 ◽  
Author(s):  
Sutep Jaruratanasirikul ◽  
Apinya Boonpeng ◽  
Monchana Nawakitrangsan ◽  
Maseetoh Samaeng
Keyword(s):  
Intensive Care Unit ◽  
Monte Carlo ◽  
Intensive Care ◽  
Extracorporeal Membrane Oxygenation ◽  
Population Pharmacokinetics ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Membrane Oxygenation ◽  
Life Threatening ◽  
Severe Infections

scholarly journals Population Pharmacokinetics of Doripenem in Critically Ill Patients with Sepsis in a Malaysian Intensive Care Unit

2015 ◽  
Vol 60 (1) ◽  
pp. 206-214 ◽  
Author(s):  
Mohd H. Abdul-Aziz ◽  
Azrin N. Abd Rahman ◽  
Mohd-Basri Mat-Nor ◽  
Helmi Sulaiman ◽  
Steven C. Wallis ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Monte Carlo ◽  
Intensive Care ◽  
Population Pharmacokinetics ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Population Pharmacokinetic Analysis ◽  
Volume Of Distribution ◽  
Pharmacokinetic Analysis ◽  
Population Pharmacokinetic

ABSTRACTDoripenem has been recently introduced in Malaysia and is used for severe infections in the intensive care unit. However, limited data currently exist to guide optimal dosing in this scenario. We aimed to describe the population pharmacokinetics of doripenem in Malaysian critically ill patients with sepsis and use Monte Carlo dosing simulations to develop clinically relevant dosing guidelines for these patients. In this pharmacokinetic study, 12 critically ill adult patients with sepsis receiving 500 mg of doripenem every 8 h as a 1-hour infusion were enrolled. Serial blood samples were collected on 2 different days, and population pharmacokinetic analysis was performed using a nonlinear mixed-effects modeling approach. A two-compartment linear model with between-subject and between-occasion variability on clearance was adequate in describing the data. The typical volume of distribution and clearance of doripenem in this cohort were 0.47 liters/kg and 0.14 liters/kg/h, respectively. Doripenem clearance was significantly influenced by patients' creatinine clearance (CLCR), such that a 30-ml/min increase in the estimated CLCRwould increase doripenem CL by 52%. Monte Carlo dosing simulations suggested that, for pathogens with a MIC of 8 mg/liter, a dose of 1,000 mg every 8 h as a 4-h infusion is optimal for patients with a CLCRof 30 to 100 ml/min, while a dose of 2,000 mg every 8 h as a 4-h infusion is best for patients manifesting a CLCRof >100 ml/min. Findings from this study suggest that, for doripenem usage in Malaysian critically ill patients, an alternative dosing approach may be meritorious, particularly when multidrug resistance pathogens are involved.

scholarly journals Pharmacokinetics of Imipenem in Critically Ill Patients with Life-threatening Severe Infections During Support with Extracorporeal Membrane Oxygenation

2019 ◽  
Vol 39 (8) ◽  
pp. 787-798 ◽  
Author(s):  
Sutep Jaruratanasirikul ◽  
Veerapong Vattanavanit ◽  
Maseetoh Samaeng ◽  
Monchana Nawakitrangsan ◽  
Somchai Sriwiriyajan
Keyword(s):  
Extracorporeal Membrane Oxygenation ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Membrane Oxygenation ◽  
Life Threatening ◽  
Severe Infections

scholarly journals Utility of transthoracic echocardiography (TTE) in assessing fluid responsiveness in critically ill patients – a challenge for the bedside sonographer.

2016 ◽  
Vol 18 (4) ◽  
pp. 508 ◽  
Author(s):  
Wojciech Mielnicki ◽  
Agnieszka Dyla ◽  
Tomasz Zawada
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Critically Ill ◽  
Fluid Responsiveness ◽  
Critically Ill Patients ◽  
Transthoracic Echocardiography ◽  
Diagnostic Tools ◽  
Dynamic Parameters ◽  
Hemodynamic Assessment ◽  
Life Threatening

Transthoracic echocardiography (TTE) has become one of the most important diagnostic tools in the treatment of critically ill patients. It allows clinicians to recognise potentially reversible life-threatening situations and is also very effective in the monitoring of the fluid status of patients, slowly substituting invasive methods in the intensive care unit. Hemodynamic assessment is based on a few static and dynamic parameters. Dynamic parameters change during the respiratory cycle in mechanical ventilation and the level of this change directly corresponds to fluid responsiveness. Most of the parameters cannot be used in spontaneously breathing patients. For these patients the most important test is passive leg raising, which is a good substitute for fluid bolus. Although TTE is very useful in the critical care setting, we should not forget the important limitations, not only technical ones but also caused by the critical illness itself. Unfortunately, this method does not allow continuous monitoring and every change in the patient’s condition requires repeated examination.Keywords: hypovolaemia; non-invasive monitoring; intensive care unit; transthoracic echocardiography

Impact of Urgent Chemotherapy in Critically Ill Patients

2017 ◽  
Vol 35 (4) ◽  
pp. 347-353 ◽  
Author(s):  
Maria Cristina Franca de Oliveira ◽  
Juliana Carvalho Ferreira ◽  
Antonio Paulo Nassar Junior ◽  
Aldo Lourenço Abbade Dettino ◽  
Pedro Caruso
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Propensity Score ◽  
Hospital Mortality ◽  
Critically Ill ◽  
Solid Tumor ◽  
Critically Ill Patients ◽  
Hematological Malignancies ◽  
Life Threatening ◽  
Life Threatening Complication

Objective: Compare the mortality between critically ill patients who received urgent chemotherapy for a cancer-related life-threatening complication with matched patients (controls) who did not received it. Design: Propensity score-matched retrospective study. Setting: Adult intensive care unit in an oncological hospital. Participants: All adults with solid tumor or hematological malignancies who received at least 1 day of urgent intravenous chemotherapy for a cancer-related life-threatening complication. Using the propensity score method adjusted for 10 variables, patients who received urgent chemotherapy were matched to patients who did not. Interventions: None. Main Outcomes Measures: Intensive care unit and hospital mortality. Results: Forty-seven patients (57% with solid tumors and 43% with hematological malignancies) who received urgent chemotherapy were matched to 94 controls. At intensive care unit admission, patients were similar except that those who received urgent chemotherapy were less likely to have received chemotherapy previously (36% vs 85%; P < .01). The intensive care unit (48.9% vs 23.4%; P < .01) and hospital (76.6% vs 46.8%; P < .01) mortality of the patients who received urgent chemotherapy was higher than the controls. The subgroup analysis showed that the higher mortality was limited to patients with solid tumor. Conclusion: The use of urgent chemotherapy is associated with an increase in the intensive care unit and hospital mortality of unselected critically ill patients with solid tumors but not in patients with hematological malignancies.

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