Differences in Predicted Warfarin Dosing Requirements Between Hmong and East Asians Using Genotype‐Based Dosing Algorithms

2020 ◽  
Author(s):  
Boguang Sun ◽  
Ya‐Feng Wen ◽  
Kathleen A. Culhane‐Pera ◽  
Muaj Lo ◽  
Txia Xiong ◽  
...  
Keyword(s):  
East Asians ◽  
Warfarin Dosing

What Does the Implicit Association Test Measure? A Test of the Convergent and Discriminant Validity of Prejudice-Related IATs

2002 ◽  
Vol 49 (3) ◽  
pp. 171-180 ◽  
Author(s):  
Bertram Gawronski
Keyword(s):  
Implicit Association Test ◽  
Discriminant Validity ◽  
Association Test ◽  
Recent Criticism ◽  
Implicit Association ◽  
East Asians ◽  
Student Sample ◽  
Convergent And Discriminant Validity ◽  
Explicit Prejudice ◽  
Turkish People

Abstract. Drawing on recent criticism of the Implicit Association Test (IAT), the present study tested the convergent and discriminant validity of two prejudice-related IATs to corresponding explicit prejudice measures in a German student sample (N = 61). Confirming convergent validity, (a) an IAT designed to assess negative associations related to Turkish people was significantly related to the explicit endorsement of prejudiced beliefs about Turkish people, and (b) an IAT designed to assess negative associations related to East Asians was significantly related to explicit prejudice against East Asians. Moreover, confirming discriminant validity, (c) the Asian IAT was unrelated to the explicit endorsement of prejudiced beliefs about Turkish people, and (d) the Turkish IAT was unrelated to explicit prejudice against Asian people. These results further corroborate the assumption that the IAT is a valid method to assess the strength of evaluative associations in the domain of prejudice and stereotypes.

scholarly journals Common genetic variants and pathways in diabetes and associated complications and vulnerability of populations with different ethnic origins

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sabrina Samad Shoily ◽  
Tamim Ahsan ◽  
Kaniz Fatema ◽  
Abu Ashfaqur Sajib
Keyword(s):  
Diabetes Mellitus ◽  
Chronic Kidney Disease ◽  
Genetic Variants ◽  
Nucleotide Polymorphisms ◽  
Differential Distribution ◽  
East Asians ◽  
Single Nucleotide ◽  
Common Genetic Variants ◽  
Haplotype Frequencies ◽  
Variant Alleles

AbstractDiabetes mellitus is a complex and heterogeneous metabolic disorder which is often pre- or post-existent with complications such as cardiovascular disease, hypertension, inflammation, chronic kidney disease, diabetic retino- and nephropathies. However, the frequencies of these co-morbidities vary among individuals and across populations. It is, therefore, not unlikely that certain genetic variants might commonly contribute to these conditions. Here, we identified four single nucleotide polymorphisms (rs5186, rs1800795, rs1799983 and rs1800629 in AGTR1, IL6, NOS3 and TNFA genes, respectively) to be commonly associated with each of these conditions. We explored their possible interplay in diabetes and associated complications. The variant allele and haplotype frequencies at these polymorphic loci vary among different super-populations (African, European, admixed Americans, South and East Asians). The variant alleles are particularly highly prevalent in different European and admixed American populations. Differential distribution of these variants in different ethnic groups suggests that certain drugs might be more effective in selective populations rather than all. Therefore, population specific genetic architectures should be considered before considering a drug for these conditions.

scholarly journals PARP1 rs1136410 Val762Ala contributes to an increased risk of overall cancer in the East Asian population: a meta-analysis

2021 ◽  
Vol 49 (3) ◽  
pp. 030006052199295
Author(s):  
Yijuan Xin ◽  
Liu Yang ◽  
Mingquan Su ◽  
Xiaoli Cheng ◽  
Lin Zhu ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Odds Ratio ◽  
Chinese Population ◽  
Meta Analysis ◽  
Asian Population ◽  
Cancer Type ◽  
East Asians ◽  
Asian Populations ◽  
Increased Risk ◽  
Meta Analyses

Objectives To investigate the association between poly(ADP-ribose) polymerase 1 ( PARP1) rs1136410 Val762Ala and cancer risk in Asian populations, as published findings remain controversial. Methods The PubMed and EMBASE databases were searched, and references of identified studies and reviews were screened, to find relevant studies. Meta-analyses were performed to evaluate the association between PARP1 rs1136410 Val762Ala and cancer risk, reported as odds ratio (OR) and 95% confidence interval (CI). Results A total of 24 studies with 8 926 cases and 15 295 controls were included. Overall, a significant association was found between PARP1 rs1136410 Val762Ala and cancer risk in East Asians (homozygous: OR 1.19, 95% CI 1.06, 1.35; heterozygous: OR 1.10, 95% CI 1.04, 1.17; recessive: OR 1.13, 95% CI 1.02, 1.25; dominant: OR 1.13, 95% CI 1.06, 1.19; and allele comparison: OR 1.09, 95% CI 1.03, 1.15). Stratification analyses by race and cancer type revealed similar results for gastric cancer among the Chinese population. Conclusion The findings suggest that PARP1 rs1136410 Val762Ala may be significantly associated with an increased cancer risk in Asians, particularly the Chinese population.

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