Tacrolimus Concentration‐to‐Dose Ratios in Kidney Transplant Recipients and Relationship to Clinical Outcomes

2019 ◽  
Vol 39 (8) ◽  
pp. 827-836 ◽  
Author(s):  
Felicia E. Bartlett ◽  
Clarice E. Carthon ◽  
Jennifer C. Hagopian ◽  
Timothy A. Horwedel ◽  
Spenser E. January ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Kidney Transplant ◽  
Tacrolimus Concentration ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

Clinical Outcomes of Older Kidney Transplant Recipients

2021 ◽  
Author(s):  
Maria Aurora Posadas Salas ◽  
Rafael David Rodriguez-Abreu ◽  
Prince Amaechi ◽  
Vinaya Rao ◽  
Karim Soliman ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

Everolimus and Long-term Clinical Outcomes in Kidney Transplant Recipients

2019 ◽  
Vol 103 (8) ◽  
pp. 1705-1713 ◽  
Author(s):  
Tracey Ying ◽  
Germaine Wong ◽  
Wai H. Lim ◽  
Philip Clayton ◽  
John Kanellis ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

scholarly journals Impact of antiretroviral therapy on clinical outcomes in HIV+ kidney transplant recipients: Review of 58 cases

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 2893 ◽  
Author(s):  
Rossana Rosa ◽  
Jose F. Suarez ◽  
Marco A. Lorio ◽  
Michele I. Morris ◽  
Lilian M. Abbo ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Acute Rejection ◽  
Clinical Outcomes ◽  
Kidney Transplant ◽  
Graft Survival ◽  
Patient Survival ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Serious Infections ◽  
The Impact

Background: Antiretroviral therapy (ART) poses challenging drug-drug interactions with immunosuppressant agents in transplant recipients.  We aimed to determine the impact of specific antiretroviral regimens in clinical outcomes of HIV+ kidney transplant recipients. Methods: A single-center, retrospective cohort study was conducted at a large academic center. Subjects included 58 HIV- to HIV+ adult, first-time kidney transplant patients. The main intervention was ART regimen used after transplantation.  The main outcomes assessed at one- and three-years were: patient survival, death-censored graft survival, and biopsy-proven acute rejection; we also assessed serious infections within the first six months post-transplant. Results: Patient and graft survival at three years were both 90% for the entire cohort. Patients receiving protease inhibitor (PI)-containing regimens had lower patient survival at one and three years than patients receiving PI-sparing regimens: 85% vs. 100% (p=0.06) and 82% vs. 100% (p=0.03), respectively. Patients who received PI-containing regimens had twelve times higher odds of death at 3 years compared to patients who were not exposed to PIs (odds ratio, 12.05; 95% confidence interval, 1.31-1602; p=0.02).  Three-year death-censored graft survival was lower in patients receiving PI vs. patients on PI-sparing regimens (82 vs 100%, p=0.03). Patients receiving integrase strand transfer inhibitors-containing regimens had higher 3-year graft survival. There were no differences in the incidence of acute rejection by ART regimen. Individuals receiving PIs had a higher incidence of serious infections compared to those on PI-sparing regimens (39 vs. 8%, p=0.01). Conclusions: PI-containing ART regimens are associated with adverse outcomes in HIV+ kidney transplant recipients.

scholarly journals Metabolic Acidosis and Long-Term Clinical Outcomes in Kidney Transplant Recipients

2016 ◽  
Vol 28 (6) ◽  
pp. 1886-1897 ◽  
Author(s):  
Seokwoo Park ◽  
Eunjeong Kang ◽  
Sehoon Park ◽  
Yong Chul Kim ◽  
Seung Seok Han ◽  
...  
Keyword(s):  
Metabolic Acidosis ◽  
Clinical Outcomes ◽  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

Periodontal status and clinical outcomes in kidney transplant recipients: A systematic review

Oral Diseases ◽  
2019 ◽  
Vol 26 (1) ◽  
pp. 22-34 ◽  
Author(s):  
Danila L. Nunes‐dos‐Santos ◽  
Samira V. Gomes ◽  
Vandilson P. Rodrigues ◽  
Antonio L. A. Pereira
Keyword(s):  
Systematic Review ◽  
Clinical Outcomes ◽  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Periodontal Status
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