A Multicenter, Prospective, Observational Study to Determine Predictive Factors for Multidrug‐Resistant Pneumonia in Critically Ill Adults: The DEFINE Study

2018 ◽  
Vol 39 (3) ◽  
pp. 253-260 ◽  
Author(s):  
Ishaq Lat ◽  
Mitchell J. Daley ◽  
Anand Shewale ◽  
Mark H. Pangrazzi ◽  
Drayton Hammond ◽  
...  
Keyword(s):  
Observational Study ◽  
Critically Ill ◽  
Predictive Factors ◽  
Prospective Observational Study ◽  
Multidrug Resistant ◽  
Multicenter Prospective Observational Study ◽  
Critically Ill Adults ◽  
Ill Adults

scholarly journals Respiratory failure requiring mechanical ventilation in critically ill adults in Ghana: A prospective observational study

2018 ◽  
Vol 8 (4) ◽  
pp. 155-157 ◽  
Author(s):  
Maxwell Osei-Ampofo ◽  
Alfred Aidoo ◽  
Akwasi Antwi-Kusi ◽  
Obiageli Joan Ofungwu ◽  
Solomon Nii-Kotey Kotey ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Respiratory Failure ◽  
Observational Study ◽  
Critically Ill ◽  
Prospective Observational Study ◽  
Critically Ill Adults ◽  
Ill Adults

scholarly journals Variation in the practice of discontinuing mechanical ventilation in critically ill adults: study protocol for an international prospective observational study

BMJ Open ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. e031775 ◽  
Author(s):  
Karen E A Burns ◽  
Leena Rizvi ◽  
Deborah J Cook ◽  
Peter Dodek ◽  
Arthur S Slutsky ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Observational Study ◽  
Research Ethics ◽  
Critically Ill ◽  
Prospective Observational Study ◽  
Demographic Data ◽  
Spontaneous Breathing Trial ◽  
Primary Objective ◽  
Critically Ill Adults ◽  
Ill Adults

IntroductionResearch supports the use of specific strategies to discontinue mechanical ventilation (MV) in critically ill patients. Little is known about how clinicians actually wean and discontinue MV in practice or the association between different discontinuation strategies and outcomes. The primary objective of this study is to describe international practices in the use of (1) daily screening for readiness to discontinue MV, (2) modes of MV used before initial discontinuation attempts, (3) weaning and spontaneous breathing trial (SBT) protocols, (4) SBT techniques and (5) sedation and mobilisation practices to facilitate weaning and discontinuation. The secondary objectives are to identify patient characteristics and time-dependent factors associated with use of selected strategies, investigate associations between SBT outcome (failure vs success) and outcomes, explore differences between patients who undergo an SBT early versus later in their intensive care unit (ICU) stay, and investigate the associations between different SBT techniques and humidification strategies on outcomes.Methods and analysisWe will conduct an international, prospective, observational study of MV discontinuation practices among critically ill adults who receive invasive MV for at least 24 hours at approximately 150 ICUs in six geographic regions (Canada, USA, UK, Europe, India and Australia/New Zealand). Research personnel at participating ICUs will collect demographic data, data to characterise the initial strategy or event that facilitated discontinuation of MV (direct extubation, direct tracheostomy, initial successful SBT, initial failed SBT or death before any attempt could be made), clinical outcomes and site information. We aim to collect data on at least 10 non-death discontinuation events in each ICU (at least 1500 non-death discontinuation events).Ethics and disseminationThis study received Research Ethics Approval from St. Michael’s Hospital (11-024) Research ethics approval will be sought from all participating sites. The results will be disseminated through publications in peer-reviewed journals.Trial registration numberNCT03955874.

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