Identifying blood‐brain barrier peptides by using amino acids physicochemical properties and features fusion method

2021 ◽  
Author(s):  
Hongliang Zou
Keyword(s):  
Amino Acids ◽  
Physicochemical Properties ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Fusion Method ◽  
Features Fusion ◽  
Blood Brain

Blood-Brain Barrier Transport of Basic Amino Acids Is Selectively Inhibited at Low pH

1983 ◽  
Vol 40 (3) ◽  
pp. 797-800 ◽  
Author(s):  
William H. Oldendorf ◽  
Paul D. Crane ◽  
Leon D. Braun ◽  
Lester A. Wade ◽  
Fared M. Diamond
Keyword(s):  
Amino Acids ◽  
Blood Brain Barrier ◽  
Low Ph ◽  
Brain Barrier ◽  
Basic Amino Acids ◽  
Blood Brain

Metabolic fuel and amino acid transport into the brain in experimental hypothyroidism

1990 ◽  
Vol 122 (2) ◽  
pp. 156-162 ◽  
Author(s):  
Arshag D. Mooradian
Keyword(s):  
Amino Acids ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Transport Systems ◽  
Brain Uptake ◽  
Acid Transport ◽  
Brain Extraction ◽  
Blood Brain ◽  
Brain Uptake Index ◽  
The Brain

Abstract The effect of hypothyroidism in the adult rat on blood-brain barrier and muscle transport of hexoses, neutral amino acids, basic amino acids, monocarboxylic acids, and ketone bodies was examined using single arterial injection-tissue sampling technique. The cerebral blood flow and brain extraction of 3H2O (internal reference substance) was not altered in 3-month-old hypothyroid rats maintained on methimazole, 0.025% in the drinking water, for 7 weeks. The brain uptake index of D-β-hydroxybutyrate was significantly reduced in hypothyroid rats (2.4 ± 0.3 vs 4.6 ± 0.6% p<0.001). Hypothyroid rats given thyroid hormone replacement therapy had normal brain uptake of D-β-hydroxybutyrate (4.4 ± 0.8%). The brain uptake index of butyrate was also significantly reduced in hypothyroid rats (39.3 ± 2.1 vs 47.2 ± 0.74%, p<0.001). The brain uptake index of other test substances and muscle uptake of nutrients examined were not altered in hypothyroid rats. These studies indicate that of the four transport systems examined in two tissues, the blood-brain barrier monocarboxylic acid transport system is most susceptible to the hypothyroidism-induced changes.

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