scholarly journals Development of novel frog‐skin peptide scaffolds with selectivity towards melanocortin receptor subtypes

2020 ◽  
Author(s):  
Uru Malik ◽  
Lai Yue Chan ◽  
Minying Cai ◽  
Victor J. Hruby ◽  
Quentin Kaas ◽  
...  
Keyword(s):  
Frog Skin ◽  
Melanocortin Receptor ◽  
Receptor Subtypes ◽  
Peptide Scaffolds

scholarly journals The Melanocortin System in Control of Inflammation

2010 ◽  
Vol 10 ◽  
pp. 1840-1853 ◽  
Author(s):  
Anna Catania ◽  
Caterina Lonati ◽  
Andrea Sordi ◽  
Andrea Carlin ◽  
Patrizia Leonardi ◽  
...  
Keyword(s):  
Receptor Activation ◽  
Brain Regions ◽  
New Drugs ◽  
Melanocortin Receptor ◽  
Receptor Subtypes ◽  
Melanocortin System ◽  
Inflammatory Disorders ◽  
Melanocyte Stimulating Hormone ◽  
Common Precursor ◽  
Anti Inflammatory

Melanocortin peptides, the collective term for α-, β-, and γ-melanocyte-stimulating hormone (α-, β-, γ-MSH) and adrenocorticotropic hormone (ACTH), are elements of an ancient modulatory system. Natural melanocortins derive from the common precursor pro-opiomelanocortin (POMC). Five receptor subtypes for melanocortins (MC1-MC5) are widely distributed in brain regions and in peripheral cells. Melanocortin receptor activation by natural or synthetic ligands exerts marked anti-inflammatory and immunomodulatory effects. The anticytokine action and the inhibitory influences on inflammatory cell migration make melanocortins potential new drugs for treatment of inflammatory disorders. Effectiveness in treatment of acute, chronic, and systemic inflammatory disorders is well documented in preclinical studies. Further, melanocortins are promising compounds in neuroprotection. This review examines the main signaling circuits in anti-inflammatory and immunomodulatory actions of melanocortins, and the potential therapeutic use of these molecules.

scholarly journals The melanocortin receptor subtypes in chicken have high preference to ACTH-derived peptides

2004 ◽  
Vol 143 (5) ◽  
pp. 626-637 ◽  
Author(s):  
Maria K Ling ◽  
Eri Hotta ◽  
Zuzana Kilianova ◽  
Tatjana Haitina ◽  
Aneta Ringholm ◽  
...  
Keyword(s):  
Melanocortin Receptor ◽  
Receptor Subtypes ◽  
High Preference

Identification of melanocortin receptor subtypes involved in lipolysis in murine 3T3-L1 adipocytes

Appetite ◽  
2009 ◽  
Vol 52 (3) ◽  
pp. 849
Author(s):  
C. Møller ◽  
K. Raun ◽  
M.L. Jacobsen ◽  
B.S. Wulff
Keyword(s):  
Melanocortin Receptor ◽  
Receptor Subtypes

Selectivity of Cyclic [d-Nal7] and [d-Phe7] Substituted MSH Analogues for the Melanocortin Receptor Subtypes

Peptides ◽  
1997 ◽  
Vol 18 (7) ◽  
pp. 1009-1013 ◽  
Author(s):  
Helgi B Schiöth ◽  
Ruta Muceniece ◽  
Felikss Mutulis ◽  
Peteris Prusis ◽  
Gunnar Lindeberg ◽  
...  
Keyword(s):  
Melanocortin Receptor ◽  
Receptor Subtypes

scholarly journals Identification of avian alpha-melanocyte-stimulating hormone in the eye: temporal and spatial regulation of expression in the developing chicken

2001 ◽  
Vol 168 (3) ◽  
pp. 527-537 ◽  
Author(s):  
K Teshigawara ◽  
S Takahashi ◽  
T Boswell ◽  
Q Li ◽  
S Tanaka ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Neural Retina ◽  
Melanocortin Receptor ◽  
Receptor Subtypes ◽  
Peripheral Tissues ◽  
Rpe Cells ◽  
Melanocyte Stimulating Hormone ◽  
Cone Cells ◽  
Stimulating Hormone

The presence and possible physiological roles of alpha-melanocyte-stimulating hormone (alpha-MSH) in the peripheral tissues of birds have not been established. By a combination of RT-PCR, immunocytochemistry and in situ hybridization, we have examined alpha-MSH expression in the eye of the chicken during development. In the 1-day-old chick, alpha-MSH was expressed in the retinal pigment epithelial (RPE) cells, and also at a lower level in the cone cells. The melanocortin receptor subtypes, CMC1, CMC4 and CMC5, were expressed in the layers of the choroid and the neural retina, but not in the RPE cells. It is probable that the RPE cells secrete alpha-MSH to exert paracrine effects on the choroid and neural retina. During embryonic development, alpha-MSH immunoreactivity in the RPE cells was initially detected at embryonic day 10, and increased in intensity as development proceeded. No cone cells were stained with anti-alpha-MSH antiserum in any of the embryonic stages tested. The immunoreactivities for two prohormone convertases, PC1 and PC2, were co-localized to the RPE cells with a pattern of staining similar to that of alpha-MSH. Despite containing alpha-MSH immunoreactivity, the RPE cells in 1-day-old chicks expressed no immunoreactivity for the endoproteases. Furthermore, in a 3-day-old chick, pro-opiomelanocortin mRNA was detectable by in situ hybridization only in the photoreceptor layer and not in the RPE cells. These results suggest that the RPE cells and the cone cells are intraocular sources of alpha-MSH in the embryonic and postnatal life of the chicken respectively. Embryonic expression of alpha-MSH in the RPE cells implies a possible role for the peptide in ocular development.

Co-operative regulation of ligand binding to melanocortin receptor subtypes: Evidence for interacting binding sites

2005 ◽  
Vol 512 (2-3) ◽  
pp. 85-95 ◽  
Author(s):  
Sergei Kopanchuk ◽  
Santa Veiksina ◽  
Ramona Petrovska ◽  
Ilze Mutule ◽  
Michael Szardenings ◽  
...  
Keyword(s):  
Ligand Binding ◽  
Binding Sites ◽  
Melanocortin Receptor ◽  
Receptor Subtypes

Targeted deletion of melanocortin receptor subtypes 3 and 4, but not CART, alters nutrient partitioning and compromises behavioral and metabolic responses to leptin

2005 ◽  
Vol 19 (11) ◽  
pp. 1482-1491 ◽  
Author(s):  
Yubin Zhang ◽  
Gail E Kilroy ◽  
Tara M. Henagan ◽  
Vera Prpic‐Uhing ◽  
William G. Richards ◽  
...  
Keyword(s):  
Melanocortin Receptor ◽  
Metabolic Responses ◽  
Receptor Subtypes ◽  
Targeted Deletion ◽  
Nutrient Partitioning
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