Electrospun progesterone‐loaded cellulose acetate nanofibers and their drug sustained‐release profiles

2020 ◽  
Vol 60 (12) ◽  
pp. 3231-3243
Author(s):  
Gabriella Onila do Nascimento Soares ◽  
Raíssa Ribeiro Lima Machado ◽  
Mariana Mendonça Diniz ◽  
Aline Bruna da Silva
Keyword(s):  
Sustained Release ◽  
Cellulose Acetate ◽  
Drug Sustained Release ◽  
Release Profiles

Development of Sustained Release Multi-Component Microparticulate System of Diclofenac Sodium and Tizanidine Hydrochloride

1970 ◽  
Vol 1 (1) ◽  
pp. 97-105
Author(s):  
Kamlesh Dashora ◽  
Shailendra Saraf ◽  
Swarnalata Saraf
Keyword(s):  
Particle Size ◽  
Sustained Release ◽  
Cellulose Acetate ◽  
Rate Constant ◽  
Diclofenac Sodium ◽  
Order Rate Constant ◽  
Anomalous Transport ◽  
First Order ◽  
Sem Study ◽  
Transport Type

Sustained released tablets of diclofenac sodium (DIC) and tizanidine hydrochloride (TIZ) were prepared by using different proportions of cellulose acetate (CA) as the retardant material. Nine formulations of tablets having different proportion of microparticles developed by varied proportions of polymer: drug ratio ‘’i.e.’’; 1:9 -1:3 for DIC and 1:1 – 3:1 for TIZ. Each tablet contained equivalent to 100 mg of DIC and 6mg of TIZ. The prepared microparticles were white, free flowing and spherical in shape (SEM study), with  the particle size varying from 78.8±1.94 to 103.33±1.28 µm and 175.92± 9.82 to 194.94±14.28µm for DIC  and TIZ, respectively.  The first order rate constant K1 of formulations were found to be in the range of  K1 = 0.117-0.272 and 0.083- 0.189 %hr-1for DIC and TIZ, respectively. The value of exponent coefficient (n) was found to be in the range of 0.6328-0.9412  and 0.8589-1.1954 for DIC and TIZ respectively indicates anomalous  to  non anomalous transport type of diffusions among different formulations

scholarly journals Development and Characterization of pH-Dependent Cellulose Acetate Phthalate Nanofibers by Electrospinning Technique

Nanomaterials ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 3202
Author(s):  
Gustavo Vidal-Romero ◽  
Virginia Rocha-Pérez ◽  
María L. Zambrano-Zaragoza ◽  
Alicia Del Real ◽  
Lizbeth Martínez-Acevedo ◽  
...  
Keyword(s):  
Cellulose Acetate ◽  
Polymer Concentration ◽  
Process Efficiency ◽  
Fickian Diffusion ◽  
Solvent Mixtures ◽  
Cellulose Acetate Phthalate ◽  
Scanning Calorimetry ◽  
Electrospinning Technique ◽  
Ph Dependent ◽  
Release Profiles

The aim of this work was to obtain pH-dependent nanofibers with an electrospinning technique as a novel controlled release system for the treatment of periodontal disease (PD). Cellulose acetate phthalate (CAP) was selected as a pH-sensitive and antimicrobial polymer. The NF was optimized according to polymeric dispersion variables, polymer, and drug concentration, and characterized considering morphology, diameter, entrapment efficiency (EE), process efficiency (PE), thermal properties, and release profiles. Two solvent mixtures were tested, and CHX-CAP-NF prepared with acetone/ethanol at 12% w/v of the polymer showed a diameter size of 934 nm, a uniform morphology with 42% of EE, and 55% of PE. Meanwhile, CHX-CAP-NF prepared with acetone/methanol at 11% w/v of polymer had a diameter of 257 nm, discontinuous nanofiber morphology with 32% of EE, and 40% of PE. EE and PE were dependent on the polymer concentration and the drug used in the formulation. Studies of differential scanning calorimetry (DSC) showed that the drug was dispersed in the NF matrix. The release profiles of CHX from CHX-CAP-NF followed Fickian diffusion dependent on time (t0.43−0.45), suggesting a diffusion–erosion process and a matrix behavior. The NF developed could be employed as a novel drug delivery system in PD.

scholarly journals Optimising Hydrogel Release Profiles for Viro-Immunotherapy Using Oncolytic Adenovirus Expressing IL-12 and GM-CSF with Immature Dendritic Cells

2020 ◽  
Vol 10 (8) ◽  
pp. 2872 ◽  
Author(s):  
Adrianne L. Jenner ◽  
Federico Frascoli ◽  
Chae-Ok Yun ◽  
Peter S. Kim
Keyword(s):  
Dendritic Cells ◽  
Sustained Release ◽  
Immune Cells ◽  
Fundamental Problem ◽  
Release Kinetics ◽  
Delivery Systems ◽  
Release Profile ◽  
Oncolytic Viruses ◽  
Immature Dendritic Cells ◽  
Release Profiles

Sustained-release delivery systems, such as hydrogels, significantly improve cancer therapies by extending the treatment efficacy and avoiding excess wash-out. Combined virotherapy and immunotherapy (viro-immunotherapy) is naturally improved by these sustained-release systems, as it relies on the continual stimulation of the antitumour immune response. In this article, we consider a previously developed viro-immunotherapy treatment where oncolytic viruses that are genetically engineered to infect and lyse cancer cells are loaded onto hydrogels with immature dendritic cells (DCs). The time-dependent release of virus and immune cells results in a prolonged cancer cell killing from both the virus and activated immune cells. Although effective, a major challenge is optimising the release profile of the virus and immature DCs from the gel so as to obtain a minimum tumour size. Using a system of ordinary differential equations calibrated to experimental results, we undertake a novel numerical investigation of different gel-release profiles to determine the optimal release profile for this viro-immunotherapy. Using a data-calibrated mathematical model, we show that if the virus is released rapidly within the first few days and the DCs are released for two weeks, the tumour burden can be significantly decreased. We then find the true optimal gel-release kinetics using a genetic algorithm and suggest that complex profiles present unnecessary risk and that a simple linear-release model is optimal. In this work, insight is provided into a fundamental problem in the growing field of sustained-delivery systems using mathematical modelling and analysis.

Ormosil nanoparticles as a sustained-release drug delivery vehicle

RSC Advances ◽  
2014 ◽  
Vol 4 (96) ◽  
pp. 53498-53504 ◽  
Author(s):  
Indrajit Roy ◽  
Pramod Kumar ◽  
Rajiv Kumar ◽  
Tymish Y. Ohulchanskyy ◽  
Ken-Tye Yong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Delivery Vehicle ◽  
Drug Delivery Vehicle ◽  
Release Drug ◽  
Ormosil Nanoparticles ◽  
Release Profiles

Tem images (above) and release profiles (below) of encapsulated drug from ormosil nanoparticles with small (orm-s), medium (orm-m) and large (orm-l) sizes.

Polydiacetylene vesicles as a novel drug sustained-release system

2010 ◽  
Vol 76 (1) ◽  
pp. 362-365 ◽  
Author(s):  
Caixin Guo ◽  
Shaoqin Liu ◽  
Zhifei Dai ◽  
Chang Jiang ◽  
Wenyuan Li
Keyword(s):  
Sustained Release ◽  
Release System ◽  
Drug Sustained Release ◽  
Novel Drug

Preparation, Characterization and In Vitro Evaluation of IVM Loaded Poly(lactic-Co-Glycolic Acid) (PLGA) Microspheres

2011 ◽  
Vol 311-313 ◽  
pp. 1751-1754
Author(s):  
Gui Yu Li ◽  
Xi Hong Lu ◽  
Xue Hu Li ◽  
Lei Tao ◽  
Jian Ping Liang
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
High Performance ◽  
Glycolic Acid ◽  
Drug Release Profile ◽  
Release Formulation ◽  
Sustained Release Formulation ◽  
Drug Delivery Carrier ◽  
Drug Sustained Release

Drug was encapsulated in a novel copolymers of poly(lactic-co-glycolic acid) (PLGA) to investigate the sustained-release formulation of drug loaded polymer microspheres delivery system. Used a modified solid-in-oil-in-water (S/O/W) emulsion solvent evaporation method to prepare microspheres, its morphology and particle size distribution were estimated by scanning electron microscopy (SEM), the profile of in vitro drug release were assessed by High performance liquid chromatography (HPLC). Finally, an stable release buffer was utilized to obtain a detailed drug release profile, which was analyzed by HPLC also. Results showed that the microspheres morphology, encapsulation efficiency and the cumulative drug release efficiency were appropriate for veterinary medicine using. The modified preparation method was simple and optimized, PLGA microspheres with excellent controlled-release characteristics may serve as drug delivery carrier and may prolong the drug sustained-release effect.

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