Nanotechnology for biomedical applications: Recent advances in neurosciences and bone tissue engineering

2017 ◽  
Vol 57 (7) ◽  
pp. 644-650 ◽  
Author(s):  
Stefano Nobile ◽  
Lucio Nobile
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Biomedical Applications ◽  
Recent Advances

Nano Hydroxyapatite (Nano-Hap): A Potential Bioceramic For Biomedical Applications

2021 ◽  
Vol 06 ◽  
Author(s):  
Varun Saxena ◽  
Lalit Pandey ◽  
T. S. Srivatsan
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Biomedical Applications ◽  
High Surface ◽  
High Surface Area ◽  
Biological Properties ◽  
Engineering Applications ◽  
Biological Responses ◽  
Size And Morphology

Background: Hydroxyapatite (HAp) is one of the most studied biomimic for biomedical applications. Specially, nano-HAp has been utilized for bone tissue engineering various orthopedic applications. HAp possesses various suitable properties such as bioactivity, biodegradability and cell proliferation efficiency for bone tissue engineering applications. Yet, lacks in self-antibacterial activity, high surface area and target efficiency. Results: In this directioon, researchers have focused on exploring the required surface as well as the inherent properties of HAp at the nanoscale. These properties are largely dependent on the composition, size and morphology of the nano-HAp. Hence, nano-HAp has been found to be an excellent candidate with an attractive combination of properties for selection and use in biomedical applications, those required to enhanced biological responses. Further, depending on the type of application, these factors can be tuned to optimize the performance. Conclusion: In this review article, we focus on the chemical structure of HAp and the routes chosen and used for the synthesis of the nano-HAp. The role of various parameters in controlling synthesis at the nanoscale are presented and briefly discussed. In addition, we provide an overview of the various applications for the pristine and doped nano-HAp with recent examples in areas spanning the following: (i) bone tissue engineering applications, (ii) drug delivery applications, (iii) surface coatings, and (iv) scaffolds. The effect of chemical composition on the mechanical properties, surface properties and biological properties are also highlighted. Nano-HAp is found to be highly proficient for its biomedical applications, especially for bone tissue engineering applications. The nano-sized properties enhances the biological responses. The dopant ions that replaces the Ca ion into the hydroxyapatite (HAp) lattice plays a crucial role in its biomedical applications

scholarly journals Bone Tissue Engineering: Recent Advances and Challenges

2012 ◽  
Vol 40 (5) ◽  
pp. 363-408 ◽  
Author(s):  
Ami R. Amini ◽  
Cato T. Laurencin ◽  
Syam P. Nukavarapu
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Recent Advances

scholarly journals Microbial-Derived Polyhydroxyalkanoate-Based Scaffolds for Bone Tissue Engineering: Biosynthesis, Properties, and Perspectives

2021 ◽  
Vol 9 ◽  
Author(s):  
Jian Li ◽  
Xu Zhang ◽  
Anjaneyulu Udduttula ◽  
Zhi Shan Fan ◽  
Jian Hai Chen ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Biomedical Applications ◽  
Large Scale ◽  
Lower Cost ◽  
Culture Conditions ◽  
Manufacturing Technologies ◽  
Insight Into

Polyhydroxyalkanoates (PHAs) are a class of structurally diverse natural biopolyesters, synthesized by various microbes under unbalanced culture conditions. PHAs as biomedical materials have been fabricated in various forms to apply to tissue engineering for the past years due to their excellent biodegradability, inherent biocompatibility, modifiable mechanical properties, and thermo-processability. However, there remain some bottlenecks in terms of PHA production on a large scale, the purification process, mechanical properties, and biodegradability of PHA, which need to be further resolved. Therefore, scientists are making great efforts via synthetic biology and metabolic engineering tools to improve the properties and the product yields of PHA at a lower cost for the development of various PHA-based scaffold fabrication technologies to widen biomedical applications, especially in bone tissue engineering. This review aims to outline the biosynthesis, structures, properties, and the bone tissue engineering applications of PHA scaffolds with different manufacturing technologies. The latest advances will provide an insight into future outlooks in PHA-based scaffolds for bone tissue engineering.

Bone tissue engineering: recent advances and promising therapeutic agents

2003 ◽  
Vol 3 (3) ◽  
pp. 409-423 ◽  
Author(s):  
Julie A Jadlowiec ◽  
Ayse B Celil ◽  
Jeffrey O Hollinger
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Therapeutic Agents ◽  
Recent Advances

scholarly journals Fabrication of Novel Silk Fibroin - LDHs Composite Arhitectures for Potential Bone Tissue Engineering

2017 ◽  
Vol 54 (4) ◽  
pp. 659-665
Author(s):  
Bianca Galateanu ◽  
Ionut Cristian Radu ◽  
Eugenia Vasile ◽  
Ariana Hudita ◽  
Mirela Violeta Serban ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Silk Fibroin ◽  
Biomedical Applications ◽  
Nanocomposite Materials ◽  
Hard Tissue ◽  
Hard Tissue Engineering ◽  
Hydrogel Nanocomposite ◽  
Hydroxyapatite Formation

Nanocomposite materials have attracted a high interest for biomedical applications because their special properties related with structure and composition. In this paper we synthesized novel hydrogel nanocomposite materials special designed for hard tissue engineering. The nanocomposite materials are able to promote hydroxyapatite formation by alternating soaking mineralization demanded for increasing of cells biocompatibility and adhesion.

scholarly journals SYNTHESIS AND CHARACTERIZATION OF COMPOSITES BASED ON HYDROXYAPATITE NANOPARTICLES AND CHITOSAN EXTRACTED FROM SHELLS OF THE FRESHWATER CRAB Potamon algeriense

2020 ◽  
Vol XXV ◽  
pp. 132-142
Author(s):  
Mohammed Lakrat ◽  
Soufiane Fadlaoui ◽  
Mohamed Aaddouz ◽  
Ouahid El Asri ◽  
Mohammed Melhaoui ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Biomedical Applications ◽  
Freshwater Crab ◽  
Hydroxyapatite Nanoparticles ◽  
X Ray Diffraction ◽  
X Ray ◽  
Nanocrystalline Hydroxyapatite

Nanocrystalline hydroxyapatite (n-HAp), which has low crystallinity, has attracted great attention due to its similarity to the inorganic part of human bone. Therefore, many studies have focused on creating new formulations combining n-HAp with some biopolymers, such as chitosan, in order to imitate biological bone tissue. The importance of chitosan and its derivatives in biomedical applications has grown significantly in the last three decades due to its biodegradability and renewable source. Besides, chitosan and its derivatives present excellent biocompatibility and biofunctionality, which make them promising materials in bone tissue engineering. In the present study, the chitosan was, first, extracted from the shell of the freshwater crab species Potamon algeriense following demineralization, deproteinization, decolouration (raw chitin) and deacetylation (chitosan) steps. Then, a novel composite based on n-HAp and extracted chitosan (CTS) with varying chitosan contents, from 5% to 20% (w/w), was synthesized and characterized for potential application in tissue regeneration. The obtained composites were characterized using X-ray diffraction, Fourier transform infrared spectroscopy and thermogravimetric analysis. The precipitated n-HAp/CTS nanocomposites similar to natural bone are promising composites for bone tissue engineering applications.

Recent advances in gene-enhanced bone tissue engineering

2018 ◽  
Vol 20 (6) ◽  
pp. e3018 ◽  
Author(s):  
Volker M. Betz ◽  
Stefan Kochanek ◽  
Stefan Rammelt ◽  
Peter E. Müller ◽  
Oliver B. Betz ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Recent Advances

scholarly journals Special Issue on “Biomaterials for Bone Tissue Engineering”

2020 ◽  
Vol 10 (8) ◽  
pp. 2660
Author(s):  
José A. Sanz-Herrera
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Special Issue ◽  
Recent Advances

The present Special Issue covers recent advances in the field of tissue engineering applied to bone tissue [...]

Sign in / Sign up

Export Citation Format

Share Document