scholarly journals Spherical calcium phosphate nanoparticle fillers allow polymer processing of bone fixation devices with high bioactivity

2009 ◽  
Vol 50 (5) ◽  
pp. 952-960 ◽  
Author(s):  
Dirk Mohn ◽  
Duygu Ege ◽  
Kirill Feldman ◽  
Oliver D. Schneider ◽  
Thomas Imfeld ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Polymer Processing ◽  
Bone Fixation ◽  
Fixation Devices ◽  
Calcium Phosphate Nanoparticle

In Vivo Behavior of Calcium Phosphate Glasses with Controlled Solubility

2005 ◽  
Vol 284-286 ◽  
pp. 893-896 ◽  
Author(s):  
Melba Navarro ◽  
E.S. Sanzana ◽  
Josep A. Planell ◽  
M.P. Ginebra ◽  
P.A. Torres
Keyword(s):  
Calcium Phosphate ◽  
Biological Response ◽  
Phosphate Glasses ◽  
New Bone Formation ◽  
Tissue Engineering Scaffolds ◽  
Bone Fixation ◽  
Vitreous System ◽  
Fixation Devices ◽  
Good Biocompatibility

Resorbable calcium phosphate glasses offer interesting solutions in the biomedical field, as bone cavity fillers, drug delivery systems, biodegradable reinforcing phase in the case of composites for bone fixation devices and tissue engineering scaffolds. In this work, two different glass formulations in the systems 44.5CaO-44.5P2O5-(11-X)Na2O-XTiO2 (X=0or 5) have been elaborated. It is known that the incorporation or TiO2 into the vitreous system reduces considerably the solubility of the glasses. To study the material solubility effect on the in vivo response, glass particles of the two formulations were implanted in rabbits. Results showed that both glasses elicited a similar biological response and good biocompatibility. The percentage of new bone formation in the glasses was comparable to that obtained for the autologous bone (control) after 12 weeks of implantation. The materials showed to have an osteoconductive potential. Finally, this study showed that in spite of the solubility difference of the studied glasses, there were no significant differences in the in vivo response.

Calcium phosphate nanoparticle-mediated transfection in 2D and 3D mono- and co-culture cell models

2019 ◽  
Vol 84 ◽  
pp. 391-401 ◽  
Author(s):  
Viktoriya Sokolova ◽  
Leonardo Rojas-Sánchez ◽  
Nataniel Białas ◽  
Nina Schulze ◽  
Matthias Epple
Keyword(s):  
Calcium Phosphate ◽  
Culture Cell ◽  
Cell Models ◽  
2D And 3D ◽  
Calcium Phosphate Nanoparticle

scholarly journals Subcutaneous tissue response and osteogenic performance of calcium phosphate nanoparticle-enriched hydrogels in the tibial medullary cavity of guinea pigs

2013 ◽  
Vol 9 (3) ◽  
pp. 5464-5474 ◽  
Author(s):  
Matilde Bongio ◽  
Jeroen J.J. van den Beucken ◽  
M. Reza Nejadnik ◽  
Zeinab Tahmasebi Birgani ◽  
Pamela Habibovic ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Guinea Pigs ◽  
Subcutaneous Tissue ◽  
Medullary Cavity ◽  
Tissue Response ◽  
Calcium Phosphate Nanoparticle

scholarly journals Effect of hydroxyapatite concentration on high-modulus composite for biodegradable bone-fixation devices

2016 ◽  
Vol 105 (7) ◽  
pp. 1963-1971 ◽  
Author(s):  
Bryant Heimbach ◽  
Kevin Grassie ◽  
Montgomery T. Shaw ◽  
James R. Olson ◽  
Mei Wei
Keyword(s):  
High Modulus ◽  
Bone Fixation ◽  
Fixation Devices

Calcium Phosphate Nanoparticle-Based Systems for Therapeutic Delivery

2019 ◽  
pp. 147-164
Author(s):  
Yun Piao ◽  
Ho Pan Bei ◽  
Allison Tam ◽  
Yuhe Yang ◽  
Qiang Zhang ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Therapeutic Delivery ◽  
Calcium Phosphate Nanoparticle

Calcium phosphate nanoparticle mediated genetic transformation in plants

2012 ◽  
Vol 22 (8) ◽  
pp. 3500 ◽  
Author(s):  
Saba Naqvi ◽  
A. N. Maitra ◽  
M. Z. Abdin ◽  
Md. Akmal ◽  
Indu Arora ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Genetic Transformation ◽  
Calcium Phosphate Nanoparticle

scholarly journals Protective efficacy of calcium phosphate nanoparticle adsorbed bivalent subunit vaccine of Pasteurella multocida against homologous challenge in mice

2020 ◽  
Author(s):  
Songyukta Shyam ◽  
Shantanu Tamuly ◽  
Probodh Borah ◽  
Rajeev Kumar Sharma
Keyword(s):  
Calcium Phosphate ◽  
Subunit Vaccine ◽  
Pasteurella Multocida ◽  
Protective Efficacy ◽  
Economic Loss ◽  
Capsular Type ◽  
Significant Protection ◽  
Type B ◽  
Serotype A ◽  
Calcium Phosphate Nanoparticle

ABSTRACTSwine pasteurellosis, caused by Pasteurella multocida capsular types A and D, causes heavy economic loss to the pig farmers. The vaccine presently used is abacterin of Pasteurella multocida capsular type B that is proven to be effective against bovine pasteurellosis. However, its efficacy against swine pasteurellosis is questionable. The present study was carried out to evaluate the efficacy of calcium phosphate nanoparticle adjuvanted bivalent subunit vaccine prepared from Pasteurella multocida capsular types A and D along with a monovalent subunit vaccine prepared from Pasteurella multocida capsular type B in mice. The Alum precipitated bacterin vaccine was used as the control. The bivalent subunit vaccine comprising the immune components of both the capsular types showed significantly higher IgG response than either of the other two vaccines. Both the calcium phosphate nanoparticle adjuvanted vaccines could elicit 100% protection in mice against homologous challenges but the aluminum hydroxide adjuvanted bacterin vaccine could not elicit significant protection. Based on this preliminary work, it was concluded that the bivalent subunit vaccine would be a better option for immunization of swine against swine pasteurellosis.IMPORTANCE OF THE WORKThe swine pasteurellosis is an important economic disease affecting the pig population in the North-eastern part of India that contributes the major pig population. The disease is caused by Serotype A and D of Pasteurella multocida. At present the inactivated vaccine is used that is actually developed against P52 strain of serotype B:2 of Pasteurella multocida, which is mainly involved in haemorrhagic septicaemia (or bovine pasteurellosis) that affects the cattle, buffaloe, sheep and goat. As a result, the present vaccine does not give sufficient protection in pigs but gives significant protection in cattle, buffaloe, sheep and goat. Hence, there is a need of development of vaccine that can address specifically swine pasteurellosis by targeting serotype A and D of Pasteurella multocida.

Sign in / Sign up

Export Citation Format

Share Document