Effect of the dispersed phase fraction on particle size in blends with high viscosity ratio

2002 ◽  
Vol 42 (10) ◽  
pp. 2005-2015 ◽  
Author(s):  
Y. G. Cho ◽  
M. R. Kamal
Keyword(s):  
Particle Size ◽  
Viscosity Ratio ◽  
High Viscosity ◽  
Phase Fraction ◽  
Dispersed Phase

scholarly journals Collagen peptide-loaded W1/O single emulsions and W1/O/W2 double emulsions: influence of collagen peptide and salt concentration, dispersed phase fraction and type of hydrophilic emulsifier on droplet stability and encapsulation efficiency

2019 ◽  
Vol 10 (6) ◽  
pp. 3312-3323 ◽  
Author(s):  
Yeon-Ji Jo ◽  
Heike Petra Karbstein ◽  
Ulrike Sabine van der Schaaf
Keyword(s):  
Salt Concentration ◽  
Encapsulation Efficiency ◽  
Phase Fraction ◽  
Dispersed Phase ◽  
Functional Ingredients ◽  
Food Grade ◽  
Double Emulsions ◽  
Collagen Peptide ◽  
Droplet Stability ◽  
Formulation Parameters

Collagen peptide-loaded double emulsions are developed by using various formulation parameters to utilize as food-grade functional ingredients with excellent droplet stability and encapsulation efficiency of collagen peptide.

scholarly journals Modification of Chitin Particles with Ionic Liquids Containing Ethyl Substituent in a Cation

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Malgorzata M. Jaworska ◽  
Andrzej Górak ◽  
Joanna Zdunek
Keyword(s):  
Particle Size ◽  
Ionic Liquid ◽  
Ionic Liquids ◽  
Hydrogen Bonds ◽  
Particle Size Distribution ◽  
Size Distribution ◽  
High Viscosity ◽  
Physical Structure ◽  
Ethyl Group ◽  
Network Of Hydrogen Bonds

Chitin cannot be dissolved in conventional solvents due to the strong inter- and intrasheet network of hydrogen bonds and the large number of crystalline regions. Some ionic liquids (ILs) have been suggested in the literature as possible solvents for chitin. Seven of them, all having an ethyl group as substituent in the cationic ring, have been tested in this work: [Emim][Cl], [Emim][Br], [Emim][I], [Emim][OAc], [Emim][Lact], [Epyr][I], and [EMS][BFSI]. Chitin was insoluble in [EMS][BFSI] while for all other ILs solubility was limited due to high viscosity of solutions and equilibria have not been reached. Changes in physical structure, particle size distribution, and crystallinity of recovered chitin depended on ionic liquid used. Increase in porosity was observed for chitin treated with [Emim][Cl], [Emim][I], [Emim][Br], and [Emim][Lact]; changes in particle size distribution were observed for [Emim][AcOH] and [EMS][BFSI]; increase in crystallinity was noticed for chitin treated with [Epyr][I] while decrease in crystallinity for [Emim][I] was noticed. All tested ionic liquids were reused four times and changes in FTIR spectra could be observed for each IL.

Investigation on the arc erosion behavior of new silver matrix composites: Part I. Reinforced by particles

2003 ◽  
Vol 18 (4) ◽  
pp. 804-816 ◽  
Author(s):  
Shou-Yi Chang ◽  
Chia-Jung Hsu ◽  
Cher-Hao Hsu ◽  
Su-Jien Lin
Keyword(s):  
Particle Size ◽  
Erosion Resistance ◽  
High Viscosity ◽  
Matrix Composites ◽  
Particle Content ◽  
Arc Erosion ◽  
Erosion Behavior ◽  
Surface Areas ◽  
Large Particles ◽  
Silver Matrix

Static-gap, single-spark tests were used to investigate the arc erosion behavior of newly developed silicon carbide and alumina particle reinforced silver matrix composites (SiCp/Ag, Al2O3p/Ag). Craters and hills exist on the surfaces of eroded silver matrix composites, and their depths and sizes decrease as the particle content increases and the particle size decreases. Obvious melting, flow, severe splash of molten silver, and the segregation of particles are present on the surfaces of eroded composites containing low volume percents of large particles. Easier silver flow results in smooth surfaces and reduces the total surface areas of the eroded composites containing large particles. The flow and splash of silver decreased with increasing particle content and decreasing particle size, exhibiting a better erosion resistance to single-spark tests. The static-gap, single-spark erosion behavior of silver matrix composites is dominated by the flow and splash of molten composites. A high viscosity of the liquids provides the composites a good arc erosion resistance.

Gastric emptying of nondigestible solids in dogs: a hydrodynamic correlation

1990 ◽  
Vol 258 (1) ◽  
pp. G65-G72 ◽  
Author(s):  
P. J. Sirois ◽  
G. L. Amidon ◽  
J. H. Meyer ◽  
J. Doty ◽  
J. B. Dressman
Keyword(s):  
Particle Size ◽  
Gastric Emptying ◽  
Gravitational Constant ◽  
Particle Density ◽  
Particle Diameter ◽  
High Viscosity ◽  
Fluid Viscosity ◽  
Fluid Flow Rate ◽  
Hydrodynamic Correlation ◽  
Viscosity Polymer

The influence of particle size, particle density, fluid viscosity, and fluid flow rate on the gastric emptying of nondigestible solids was investigated in five dogs with chronically placed fistulas. Six hundred and fifty particles of 13 different size and density combinations were administered simultaneously with 500 ml of either normal saline or low-, medium-, or high-viscosity polymer solutions. The canine stomach was found to discriminate between these solids on the basis of size and density at all levels of viscosity above saline. The observed patterns of emptying are consistent with the hypothesis that gastric emptying of nondigestible solids is governed in part by hydrodynamics and correlate well with the gastric-emptying coefficient (GEC), a dimensionless grouping of variables that takes the form GEC = (Dpy/Dp) [g(rho f - rho p)Dp2]/[eta (nu)] where [g(rho f - rho p)] is particle buoyancy consisting of fluid (rho f) and particle (rho p) densities and g, the gravitational constant; (Dp) is the particle diameter, (Dpy) the estimated pyloric diameter, eta the fluid viscosity, and (nu) the average linear velocity of fluid exiting the stomach.

scholarly journals A CFD study on horizontal oil-water flow with high viscosity ratio

2021 ◽  
Vol 229 ◽  
pp. 116097
Author(s):  
Jing Shi ◽  
Mustapha Gourma ◽  
Hoi Yeung
Keyword(s):  
Water Flow ◽  
Viscosity Ratio ◽  
High Viscosity ◽  
Oil Water

scholarly journals Formulation of Sustained Release Hydrophilic Matrix Tablets of Tolcapone with the Application of Sedem Diagram: Influence of Tolcapone’s Particle Size on Sustained Release

Pharmaceutics ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 674 ◽  
Author(s):  
Anna Nardi-Ricart ◽  
Isaac Nofrerias-Roig ◽  
Marc Suñé-Pou ◽  
Pilar Pérez-Lozano ◽  
Montse Miñarro-Carmona ◽  
...  
Keyword(s):  
Particle Size ◽  
Sustained Release ◽  
Potent Inhibitor ◽  
High Viscosity ◽  
Matrix Tablets ◽  
Formulation Development ◽  
Methyl Transferase ◽  
Diagram Method ◽  
Hydrophilic Matrix ◽  
Amyloid Polyneuropathy

Hydrophilic matrix tablets are a type of sustained release dosage form characterized by distributing a drug in a matrix that is usually polymeric. Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase. In recent years, it has been shown that tolcapone is a potent inhibitor of the amyloid aggregation process of the transthyretin protein, and acts by stabilizing the structure of the protein, reducing the progression of familial amyloid polyneuropathy. The main objective of this study was to obtain a sustained release tablet of tolcapone for oral administration with a preferred dosage regimen of 1 administration every 12 or 24 h and manufactured, preferably, by direct compression. The SeDeM Diagram method has been used for the formulation development of hydrophilic matrix tablets. Given the characteristics of tolcapone, the excipient selected for the formation of the polymeric matrix was a high viscosity hydroxypropylmethylcellulose (Methocel® K100M CR). A decrease in the particle size of tolcapone resulted in a slower dissolution release of the formulation when the concentration of the polymer Methocel® K100M CR was below 29%. These surprising and novel results have given rise to patent number WO/2018/019997.

Determination of Particle Size of a Dispersed Phase by Small-Angle X-ray Scattering

1989 ◽  
Vol 171 ◽  
Author(s):  
Frank C. Wilson
Keyword(s):  
Particle Size ◽  
High Resolution ◽  
Spherical Particles ◽  
Dispersed Phase ◽  
X Ray ◽  
X Ray Scattering ◽  
Resultant Data ◽  
Log Normal ◽  
Log Normal Distribution

ABSTRACTA method for determining particle diameters up to ca 500 rnm is described. X-ray data are obtained with an ultra-high resolution Bonse-Hart diffractometer and subsequently desmeared. The resultant data, viewed as the invariant argument h l(h), are interpreted as arising from a log-normal distribution of independent spherical particles. The distribution is characterized by its median value and breadth.

Sign in / Sign up

Export Citation Format

Share Document