scholarly journals Clinical characteristics and post‐discharge follow‐up analyses of 10 infants with congenital tuberculosis: A retrospective observational study

2021 ◽  
Vol 5 (2) ◽  
pp. 86-93
Author(s):  
Juan Du ◽  
Shixiao Dong ◽  
Shengnan Jia ◽  
Qiaoru Zhang ◽  
Mingyan Hei
Keyword(s):  
Observational Study ◽  
Clinical Characteristics ◽  
Retrospective Observational Study ◽  
Post Discharge ◽  
Congenital Tuberculosis

Clinical characteristics and post-discharge follow-up analysis of 10 cases of congenital tuberculosis: a retrospective observational study

2019 ◽  
Author(s):  
Juan Du ◽  
Shixiao Dong ◽  
Shengnan Jia ◽  
Qiaoru Zhang ◽  
Mingyan Hei
Keyword(s):  
Observational Study ◽  
Clinical Manifestations ◽  
Pulmonary Nodules ◽  
Retrospective Observational Study ◽  
Post Discharge ◽  
Abdominal Ultrasonography ◽  
Tb Treatment ◽  
Congenital Tuberculosis ◽  
Imaging Results

Abstract Background Congenital tuberculosis (TB) is a rare disease with a high mortality. In this study, we reviewed patients with congenital TB that were promptly treated with an anti-TB regimen, including linezolid, based on new clinical diagnosis criteria. We described the clinical manifestations, treatment, and long-term prognosis of this disease in these patients. Methods This was a retrospective observational study that enrolled patients with congenital TB that were admitted to Beijing Children’s Hospital between 2009 and 2018. Results A total of 10 congenital TB patients were enrolled. Ninety-percentage of the mothers were diagnosed at postpartum; however, none of the mothers received anti-TB treatment during pregnancy. The onset age of congenital TB ranged from 1 to 53 days. Chest computed tomography scans demonstrated pulmonary nodules in 100% of the patients and mediastinal adenopathy in 40% of the patients. Abdominal ultrasonography showed hypoechoic nodules in the liver and spleen in 40% of the patients. The positive rate of GeneXpert and T-spot were relatively high—80% and 78%, respectively. Anti-TB treatment was started when congenital TB was confirmed for 1 patient based on TB-specific tests or clinically diagnosed for the other 9 patients based on confirmed maternal TB history and typical radiological findings. Beside isoniazid, rifampicin, and pyrazinamide, linezolid was also administrated in 70% of the patients for a period of 2–6 months. One patient was reported to present with spontaneously resolved thrombocytopenia. The survival rate was 100%, and 33% of the patients have thrived and reached normal developmental milestones since the last documented follow-up. Conclusion Congenital TB is a potentially fatal disease, but early diagnosis based on maternal history, typical imaging results, and timely treatment can improve the outcome. Linezolid is safe and might be effective in reducing the mortality of congenital TB.

scholarly journals Clinical characteristics of hypertrophic herpes simplex genitalis and treatment outcomes of imiquimod: a retrospective observational study

2015 ◽  
Vol 33 ◽  
pp. 165-170 ◽  
Author(s):  
Charussri Leeyaphan ◽  
Theetat M. Surawan ◽  
Pornchai Chirachanakul ◽  
Nuntida Prasertworonun ◽  
Praewphan Punyaratabandhu ◽  
...  
Keyword(s):  
Herpes Simplex ◽  
Observational Study ◽  
Treatment Outcomes ◽  
Clinical Characteristics ◽  
Retrospective Observational Study

scholarly journals Analysis of Management Approach to Newborn Care of Infants Delivered to COVID-19 Positive Mothers at Five Tertiary Care Centers in the UAE over a 7 Month Period 

2021 ◽  
Author(s):  
Monika Kaushal ◽  
Yamuna Tulasi ◽  
Ayush Kaushal ◽  
Aditya Rakhecha ◽  
Rafiq Memon ◽  
...  
Keyword(s):  
Observational Study ◽  
Tertiary Care ◽  
Newborn Care ◽  
Retrospective Observational Study ◽  
Management Approach ◽  
Post Discharge ◽  
Formula Milk ◽  
Increased Risk ◽  
Care Practices ◽  
Tertiary Care Centers

Abstract ObjectivesTo assess newborn care practices, clinical characters and risks of mother to child transmission during rooming in and breastfeeding in infants born to mothers with COVID-19.DesignRetrospective observational study.Participants5 Tertiary care centers located in the UAE. Infants born to mothers diagnosed with COVID-19 at the time of delivery, born between April 1st and October 30th 2020.MethodsIn this retrospective observational study, we analyzed the newborn care practices in various tertiary care hospitals and the rate of transmission of SARS-CoV-2 from mother to infant (vertical or horizontal) while rooming in, breastfeeding and post discharge. Results40 infants were born to mothers with COVID-19 at the time of delivery. One infant tested positive for SARS-CoV-2 after birth and had respiratory symptoms and fever. 23 of the well infants were roomed in during their hospital stay and were breastfed. In 8 cases, the mother and baby were separated and isolated from the time of birth till discharge. 95% of the discharged infants were rooming in with mothers, 45% of the infants were exclusively breastfed and 55% were on mixed feeding (breast milk and formula milk) at the follow-up. None of the infants developed significant health issues or symptoms attributable to SARS-CoV-2.ConclusionThe risk of mother to infant transmission of COVID-19 in the perinatal period is very low. Our study reaffirms the AAP guidelines that rooming in and breastfeeding of newborns born to COVID-19 positive mothers is safe without an increased risk of transmission by following mandated safety precautions.

scholarly journals Neonatal outcomes in pregnant women infected with COVID-19 in Babol, North of Iran: retrospective study with short-term follow-up

2021 ◽  
Author(s):  
Zahra Akbarian-Rad ◽  
Mohsen Haghshenas Mojaveri ◽  
Zinatossadat Bouzari ◽  
Farzin Sadeghi ◽  
Yousef Yahyapour ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Clinical Characteristics ◽  
Neonatal Outcomes ◽  
Short Term ◽  
Post Discharge ◽  
Reactive Protein ◽  
Clinical Presentations ◽  
North Of Iran

Abstract During the Coronavirus disease 2019 (COVID-19) pandemic, the number of pregnant women and neonates suffering from COVID-19 increased. However, there is a lack of evidence on clinical characteristics and neonatal outcomes in pregnant women with COVID-19. We evaluated short-term outcomes (4 weeks post-discharge) and symptoms in neonates born to mothers infected with COVID-19. In this retrospective cohort study, we included all neonates born to pregnant women with COVID-19 who were admitted to Ayatollah Rohani Hospital, Babol, Iran, from February 10 to May 20, 2020. Clinical features, treatments, and neonatal outcomes were measured. Eight neonates were included in the current study. The mean gestational age and birth weight of newborns were 37 ± 3.19 weeks (30₊6 − 40) and 3077.50 ± 697.64 gr (1720–3900) respectively. Apgar score of the first and fifth minutes in all neonates was ≥ 8 and ≥ 9 out of 10 respectively. The most clinical presentations in symptomatic neonates were respiratory distress, tachypnea, vomiting, and feeding intolerance. This manifestation and high levels of serum C-reactive protein (CRP), in three infants, are common in neonatal sepsis. The blood culture in all of them was negative. They have been successfully treated with our standard treatment. Our pregnant women showed a pattern of clinical characteristics and laboratory results almost similar to those described for non-pregnant COVID-19 infection. This study found no evidence of intrauterine or peripartum transmission of COVID-19 from mother to her child. Furthermore, the long-term outcomes of neonates need more study.

scholarly journals Routine Follow-Up Radiographs for Ankle Fractures Seldom Add Value to Clinical Decision-Making: A Retrospective, Observational Study

2018 ◽  
Vol 57 (5) ◽  
pp. 957-960 ◽  
Author(s):  
Pieter van Gerven ◽  
Nikki L. Weil ◽  
Marco F. Termaat ◽  
Sidney M. Rubinstein ◽  
Mostafa El Moumni ◽  
...  
Keyword(s):  
Decision Making ◽  
Observational Study ◽  
Clinical Decision Making ◽  
Clinical Decision ◽  
Ankle Fractures ◽  
Retrospective Observational Study

scholarly journals Clinical characteristics and outcomes of measles outbreak in adults: A multicenter retrospective observational study of 93 hospitalized adults in Greece

2020 ◽  
Vol 131 ◽  
pp. 104608
Author(s):  
Paraskevi C. Fragkou ◽  
Konstantinos Thomas ◽  
Styliani Sympardi ◽  
George D. Liatsos ◽  
Maria Pirounaki ◽  
...  
Keyword(s):  
Observational Study ◽  
Clinical Characteristics ◽  
Retrospective Observational Study ◽  
Measles Outbreak
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