Impact of a drug safety communication on the severity of benzonatate exposures reported to poison centers

2020 ◽  
Vol 30 (1) ◽  
pp. 45-52
Author(s):  
James B. Leonard ◽  
Hyunuk Seung ◽  
Wendy Klein‐Schwartz
Keyword(s):  
Drug Safety ◽  
Safety Communication ◽  
Poison Centers

scholarly journals Changes in the utilization of osteoporosis drugs after the 2010 FDA bisphosphonate drug safety communication

2018 ◽  
Vol 26 (2) ◽  
pp. 238-243 ◽  
Author(s):  
Bander Balkhi ◽  
Enrique Seoane-Vazquez ◽  
Rosa Rodriguez-Monguio
Keyword(s):  
Drug Safety ◽  
Safety Communication

scholarly journals Correction to: Safety Communication Tools and Healthcare Professionals’ Awareness of Specific Drug Safety Issues in Europe: A Survey Study

Drug Safety ◽  
2020 ◽  
Vol 43 (8) ◽  
pp. 827-829
Author(s):  
Sieta T. de Vries ◽  
◽  
Maartje J. M. van der Sar ◽  
Anna Marie Coleman ◽  
Yvette Escudero ◽  
...  
Keyword(s):  
Drug Safety ◽  
Healthcare Professionals ◽  
Survey Study ◽  
Specific Drug ◽  
Communication Tools ◽  
Safety Communication ◽  
Safety Issues

scholarly journals Social Media Impact of the Food and Drug Administration's Drug Safety Communication Messaging About Zolpidem: Mixed-Methods Analysis

2018 ◽  
Vol 4 (1) ◽  
pp. e1 ◽  
Author(s):  
Michael S Sinha ◽  
Clark C Freifeld ◽  
John S Brownstein ◽  
Macarius M Donneyong ◽  
Paula Rausch ◽  
...  
Keyword(s):  
Social Media ◽  
Mixed Methods ◽  
Drug Safety ◽  
Safety Communication ◽  
Media Impact

scholarly journals Safety Communication Tools and Healthcare Professionals’ Awareness of Specific Drug Safety Issues in Europe: A Survey Study

Drug Safety ◽  
2018 ◽  
Vol 41 (7) ◽  
pp. 713-724 ◽  
Author(s):  
Sieta T. de Vries ◽  
◽  
Maartje J. M. van der Sar ◽  
Anna Marie Coleman ◽  
Yvette Escudero ◽  
...  
Keyword(s):  
Drug Safety ◽  
Healthcare Professionals ◽  
Survey Study ◽  
Specific Drug ◽  
Communication Tools ◽  
Safety Communication ◽  
Safety Issues

Changes in Long-acting β-agonist Utilization After the FDA’s 2010 Drug Safety Communication

2015 ◽  
Vol 37 (1) ◽  
pp. 114-123.e1 ◽  
Author(s):  
Daniel M. Hartung ◽  
Luke Middleton ◽  
Sheila Markwardt ◽  
Kaylee Williamson ◽  
Kathy Ketchum
Keyword(s):  
Drug Safety ◽  
Safety Communication ◽  
Long Acting

scholarly journals Impact of a US Food and Drug Administration Drug Safety Communication on Zolpidem Dosing

2015 ◽  
Author(s):  
Jonathan L. Harward ◽  
Valerie B. Clinard ◽  
Michael R. Jiroutek ◽  
Beverly H. Lingerfeldt ◽  
Andrew J. Muzyk
Keyword(s):  
Drug Administration ◽  
Drug Safety ◽  
Food And Drug Administration ◽  
Safety Communication

scholarly journals Using Natural Language Processing to Examine the Uptake, Content, and Readability of Media Coverage of a Pan-Canadian Drug Safety Research Project: Cross-Sectional Observational Study (Preprint)

2019 ◽  
Author(s):  
Hossein Mohammadhassanzadeh ◽  
Ingrid Sketris ◽  
Robyn Traynor ◽  
Susan Alexander ◽  
Brandace Winquist ◽  
...  
Keyword(s):  
Natural Language Processing ◽  
Natural Language ◽  
Health Information ◽  
Language Processing ◽  
Drug Safety ◽  
Media Coverage ◽  
Reading Level ◽  
Safety Communication ◽  
Safety Research ◽  
The Media

BACKGROUND Isotretinoin, for treating cystic acne, increases the risk of miscarriage and fetal abnormalities when taken during pregnancy. The Health Canada–approved product monograph for isotretinoin includes pregnancy prevention guidelines. A recent study by the Canadian Network for Observational Drug Effect Studies (CNODES) on the occurrence of pregnancy and pregnancy outcomes during isotretinoin therapy estimated poor adherence to these guidelines. Media uptake of this study was unknown; awareness of this uptake could help improve drug safety communication. OBJECTIVE The aim of this study was to understand how the media present pharmacoepidemiological research using the CNODES isotretinoin study as a case study. METHODS Google News was searched (April 25-May 6, 2016), using a predefined set of terms, for mention of the CNODES study. In total, 26 articles and 3 CNODES publications (original article, press release, and podcast) were identified. The article texts were cleaned (eg, advertisements and links removed), and the podcast was transcribed. A dictionary of 1295 unique words was created using natural language processing (NLP) techniques (term frequency-inverse document frequency, Porter stemming, and stop-word filtering) to identify common words and phrases. Similarity between the articles and reference publications was calculated using Euclidian distance; articles were grouped using hierarchical agglomerative clustering. Nine readability scales were applied to measure text readability based on factors such as number of words, difficult words, syllables, sentence counts, and other textual metrics. RESULTS The top 5 dictionary words were <italic>pregnancy</italic> (250 appearances), <italic>isotretinoin</italic> (220), <italic>study</italic> (209), <italic>drug</italic> (201), and <italic>women</italic> (185). Three distinct clusters were identified: Clusters 2 (5 articles) and 3 (4 articles) were from health-related websites and media, respectively; Cluster 1 (18 articles) contained largely media sources; 2 articles fell outside these clusters. Use of the term <italic>isotretinoin</italic> versus <italic>Accutane</italic> (a brand name of isotretinoin), discussion of pregnancy complications, and assignment of responsibility for guideline adherence varied between clusters. For example, the term <italic>pregnanc</italic> appeared most often in Clusters 1 (14.6 average times per article) and 2 (11.4) and relatively infrequently in Cluster 3 (1.8). Average readability for all articles was high (eg, Flesch-Kincaid, 13; Gunning Fog, 15; SMOG Index, 10; Coleman Liau Index, 15; Linsear Write Index, 13; and Text Standard, 13). Readability increased from Cluster 2 (Gunning Fog of 16.9) to 3 (12.2). It varied between clusters (average 13th-15th grade) but exceeded the recommended health information reading level (grade 6th to 8th), overall. CONCLUSIONS Media interpretation of the CNODES study varied, with differences in synonym usage and areas of focus. All articles were written above the recommended health information reading level. Analyzing media using NLP techniques can help determine drug safety communication effectiveness. This project is important for understanding how drug safety studies are taken up and redistributed in the media.

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