scholarly journals Prevalence, incidence, indication, and choice of antidepressants in patients with and without chronic kidney disease: a matched cohort study in UK Clinical Practice Research Datalink

2017 ◽  
Vol 26 (7) ◽  
pp. 792-801 ◽  
Author(s):  
Masao Iwagami ◽  
Laurie A. Tomlinson ◽  
Kathryn E. Mansfield ◽  
Helen I. McDonald ◽  
Liam Smeeth ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Cohort Study ◽  
Clinical Practice ◽  
Kidney Disease ◽  
Practice Research ◽  
Clinical Practice Research Datalink ◽  
Matched Cohort ◽  
Matched Cohort Study

scholarly journals Gout and the risk of advanced chronic kidney disease in the UK health system: a national cohort study

BMJ Open ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. e031550 ◽  
Author(s):  
Austin G Stack ◽  
Michelle Elizabeth Johnson ◽  
Betina Blak ◽  
Alyssa Klein ◽  
Lewis Carpenter ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Cohort Study ◽  
Kidney Disease ◽  
Serum Creatinine ◽  
International Classification Of Diseases ◽  
Secondary Outcome ◽  
Practice Research ◽  
Clinical Practice Research Datalink ◽  
Advanced Chronic Kidney Disease ◽  
National Cohort

ObjectiveEvaluate the association between gout and risk of advanced chronic kidney disease (CKD).DesignRetrospective matched cohort study.SettingUK Clinical Practice Research Datalink.ParticipantsThe analysis included data for 68 897 patients with gout and 554 964 matched patients without gout. Patients were aged ≥18 years, registered at UK practices, had ≥12 months of clinical data and had data linked with Hospital Episode Statistics. Patients were excluded for history of advanced CKD, juvenile gout, cancer, HIV, tumour lysis syndrome, Lesch-Nyhan syndrome or familial Mediterranean fever.Primary and secondary outcome measuresAdvanced CKD was defined as first occurrence of: (1) dialysis, kidney transplant, diagnosis of end-stage kidney disease (ESKD) or stage 5 CKD (diagnostic codes in Read system or International Classification of Diseases, Tenth Revision); (2) estimated glomerular filtration rate (eGFR) <10 mL/min/1.73 m²; (3) doubling of serum creatinine from baseline and (4) death associated with CKD.ResultsAdvanced CKD incidence was higher for patients with gout (8.54 per 1000 patient-years; 95% CI 8.26 to 8.83) versus without gout (4.08; 95% CI 4.00 to 4.16). Gout was associated with higher advanced CKD risk in both unadjusted analysis (HR, 2.00; 95% CI 1.92 to 2.07) and after adjustment (HR, 1.29; 95% CI 1.23 to 1.35). Association was strongest for ESKD (HR, 2.13; 95% CI 1.73 to 2.61) and was present for eGFR <10 mL/min/1.73 m² (HR, 1.45; 95% CI 1.30 to 1.61) and serum creatinine doubling (HR, 1.13; 95% CI 1.08 to 1.19) but not CKD-associated death (HR, 1.14; 95% CI 0.99 to 1.31). Association of gout with advanced CKD was replicated in propensity-score matched analysis (HR, 1.23; 95% CI 1.17 to 1.29) and analysis limited to patients with incident gout (HR, 1.28; 95% CI 1.22 to 1.35).ConclusionsGout is associated with elevated risk of CKD progression. Future studies should investigate whether controlling gout is protective and reduces CKD risk.

scholarly journals Is schizophrenia associated with an increased risk of chronic kidney disease? A nationwide matched-cohort study

BMJ Open ◽  
2015 ◽  
Vol 5 (1) ◽  
pp. e006777-e006777 ◽  
Author(s):  
N.-S. Tzeng ◽  
Y.-H. Hsu ◽  
S.-Y. Ho ◽  
Y.-C. Kuo ◽  
H.-C. Lee ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Cohort Study ◽  
Kidney Disease ◽  
Matched Cohort ◽  
Matched Cohort Study ◽  
Increased Risk

Risk of Colorectal Cancer in Chronic Kidney Disease: A Matched Cohort Study Based on Administrative Data

2013 ◽  
Vol 20 (12) ◽  
pp. 3885-3891 ◽  
Author(s):  
Mei-Yi Wu ◽  
Tung-Cheng Chang ◽  
Tsu-Yi Chao ◽  
Ming-Te Huang ◽  
Hui-Wen Lin
Keyword(s):  
Colorectal Cancer ◽  
Chronic Kidney Disease ◽  
Cohort Study ◽  
Kidney Disease ◽  
Administrative Data ◽  
Matched Cohort ◽  
Matched Cohort Study

scholarly journals Cardiovascular risk is similar in patients with glomerulonephritis compared to other types of chronic kidney disease: a matched cohort study

2017 ◽  
Vol 18 (1) ◽  
Author(s):  
Holly L. Hutton ◽  
Adeera Levin ◽  
Jagbir Gill ◽  
Ognjenka Djurdjev ◽  
Mila Tang ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Cohort Study ◽  
Cardiovascular Risk ◽  
Kidney Disease ◽  
Matched Cohort ◽  
Matched Cohort Study
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